LOCUS       NP_001005555             531 aa            linear   ROD 11-DEC-2024
DEFINITION  polypyrimidine tract-binding protein 2 [Rattus norvegicus].
ACCESSION   NP_001005555 XP_227635
VERSION     NP_001005555.1
DBSOURCE    REFSEQ: accession NM_001005555.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 531)
  AUTHORS   Braunschweig,U., Gueroussov,S., Plocik,A.M., Graveley,B.R. and
            Blencowe,B.J.
  TITLE     Dynamic integration of splicing within gene regulatory pathways
  JOURNAL   Cell 152 (6), 1252-1269 (2013)
   PUBMED   23498935
  REMARK    Review article
REFERENCE   2  (residues 1 to 531)
  AUTHORS   Licatalosi,D.D., Yano,M., Fak,J.J., Mele,A., Grabinski,S.E.,
            Zhang,C. and Darnell,R.B.
  TITLE     Ptbp2 represses adult-specific splicing to regulate the generation
            of neuronal precursors in the embryonic brain
  JOURNAL   Genes Dev 26 (14), 1626-1642 (2012)
   PUBMED   22802532
REFERENCE   3  (residues 1 to 531)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (residues 1 to 531)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 531)
  AUTHORS   Bitel,C.L., Perrone-Bizzozero,N.I. and Frederikse,P.H.
  TITLE     HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell
            identity are also utilized in the lens
  JOURNAL   Mol Vis 16, 2301-2316 (2010)
   PUBMED   21139978
  REMARK    GeneRIF: The predominant expression of REST4, HuB/C/D and nPTB in
            post-mitotic fiber cells, together with miR-124 expression in
            vertebrate lenses, was shown.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 531)
  AUTHORS   Tateiwa,H., Gotoh,N., Ichikawa,M., Kikuchi,T. and Yoshimura,N.
  TITLE     Molecular cloning and characterization of human PTB-like protein: a
            possible retinal autoantigen of cancer-associated retinopathy
  JOURNAL   J Neuroimmunol 120 (1-2), 161-169 (2001)
   PUBMED   11694331
REFERENCE   7  (residues 1 to 531)
  AUTHORS   Kikuchi,T., Ichikawa,M., Arai,J., Tateiwa,H., Fu,L., Higuchi,K. and
            Yoshimura,N.
  TITLE     Molecular cloning and characterization of a new neuron-specific
            homologue of rat polypyrimidine tract binding protein
  JOURNAL   J Biochem 128 (5), 811-821 (2000)
   PUBMED   11056394
REFERENCE   8  (residues 1 to 531)
  AUTHORS   Polydorides,A.D., Okano,H.J., Yang,Y.Y., Stefani,G. and
            Darnell,R.B.
  TITLE     A brain-enriched polypyrimidine tract-binding protein antagonizes
            the ability of Nova to regulate neuron-specific alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6350-6355 (2000)
   PUBMED   10829067
REFERENCE   9  (residues 1 to 531)
  AUTHORS   Zhang,L., Liu,W. and Grabowski,P.J.
  TITLE     Coordinate repression of a trio of neuron-specific splicing events
            by the splicing regulator PTB
  JOURNAL   RNA 5 (1), 117-130 (1999)
   PUBMED   9917071
REFERENCE   10 (residues 1 to 531)
  AUTHORS   Ashiya,M. and Grabowski,P.J.
  TITLE     A neuron-specific splicing switch mediated by an array of pre-mRNA
            repressor sites: evidence of a regulatory role for the
            polypyrimidine tract binding protein and a brain-specific PTB
            counterpart
  JOURNAL   RNA 3 (9), 996-1015 (1997)
   PUBMED   9292499
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082076.1.
            
            On Oct 8, 2004 this sequence version replaced XP_227635.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     Protein         1..531
                     /product="polypyrimidine tract-binding protein 2"
                     /note="PTB-like protein; neural polypyrimidine
                     tract-binding protein"
                     /calculated_mol_wt=57358
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9UKA9; propagated from
                     UniProtKB/Swiss-Prot (Q66H20.1)"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q91Z31; propagated from
                     UniProtKB/Swiss-Prot (Q66H20.1)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q91Z31; propagated from
                     UniProtKB/Swiss-Prot (Q66H20.1)"
     Region          57..531
                     /region_name="hnRNP-L_PTB"
                     /note="hnRNP-L/PTB/hephaestus splicing factor family;
                     TIGR01649"
                     /db_xref="CDD:273733"
     Site            308
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q66H20.1)"
     CDS             1..531
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /coded_by="NM_001005555.1:85..1680"
                     /db_xref="GeneID:310820"
                     /db_xref="RGD:1359267"
ORIGIN      
        1 mdgivtevav gvkrgsdell sgsvlsspns nmsgmvvtan gndskkfkge dkmdgapsrv
       61 lhirklpgev tetevialgl pfgkvtnilm lkgknqafle lateeaaitm vnyysavtph
      121 lrnqpiyiqy snhkelktdn tlnqraqvvl qavtavqtan tplsgttvse savtpaqspv
      181 lriiidnmyy pvtldvlhqi fskfgavlki itftknnqfq allqygdpvn aqqaklaldg
      241 qniynacctl ridfsklvnl nvkynndksr dytrpdlpsg dgqpaldpai aaafaketsl
      301 lavpgalspl aipnaaaaaa aaaagrvgmp gvsaggntvl lvsnlneemv tpqslftlfg
      361 vygdvqrvki lynkkdsali qmadgnqsql amnhlngqkm ygkiirvtls khqtvqlpre
      421 glddqgltkd fgnsplhrfk kpgsknfqni fppsatlhls nippsvaeed lrtlfantgg
      481 tvkafkffqd hkmallqmat veeaiqalid lhnynlgenh hlrvsfskst i
//
