LOCUS       NM_001271057            2905 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Rattus norvegicus polypyrimidine tract binding protein 1 (Ptbp1),
            transcript variant 1, mRNA.
ACCESSION   NM_001271057
VERSION     NM_001271057.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2905)
  AUTHORS   Su,Y., Tian,W., Cheng,L., Yin,L., He,X. and Wei,X.
  TITLE     Inhibition of IGF2BP1 attenuates the progression of endometriosis
            through PTBP1
  JOURNAL   Folia Histochem Cytobiol 62 (1), 25-36 (2024)
   PUBMED   38563050
  REMARK    GeneRIF: Inhibition of IGF2BP1 attenuates the progression of
            endometriosis through PTBP1.
REFERENCE   2  (bases 1 to 2905)
  AUTHORS   Lu,G.F., Geng,F., Deng,L.P., Lin,D.C., Huang,Y.Z., Lai,S.M.,
            Lin,Y.C., Gui,L.X., Sham,J.S.K. and Lin,M.J.
  TITLE     Reduced CircSMOC1 Level Promotes Metabolic Reprogramming via PTBP1
            (Polypyrimidine Tract-Binding Protein) and miR-329-3p in Pulmonary
            Arterial Hypertension Rats
  JOURNAL   Hypertension 79 (11), 2465-2479 (2022)
   PUBMED   35997022
  REMARK    GeneRIF: Reduced CircSMOC1 Level Promotes Metabolic Reprogramming
            via PTBP1 (Polypyrimidine Tract-Binding Protein) and miR-329-3p in
            Pulmonary Arterial Hypertension Rats.
REFERENCE   3  (bases 1 to 2905)
  AUTHORS   Yan,G., Sun,R., Chen,Z., Pan,X., Sheng,Z. and Tang,C.
  TITLE     PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic
            Transformation of Pulmonary Artery Smooth Muscle Cells
  JOURNAL   Drug Des Devel Ther 15, 2025-2033 (2021)
   PUBMED   34012255
  REMARK    GeneRIF: PTBP1 Targets ILK to Regulate the Hypoxia-Induced
            Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2905)
  AUTHORS   Ramos,A.D., Andersen,R.E., Liu,S.J., Nowakowski,T.J., Hong,S.J.,
            Gertz,C., Salinas,R.D., Zarabi,H., Kriegstein,A.R. and Lim,D.A.
  TITLE     The long noncoding RNA Pnky regulates neuronal differentiation of
            embryonic and postnatal neural stem cells
  JOURNAL   Cell Stem Cell 16 (4), 439-447 (2015)
   PUBMED   25800779
REFERENCE   5  (bases 1 to 2905)
  AUTHORS   Lin,N., Chang,K.Y., Li,Z., Gates,K., Rana,Z.A., Dang,J., Zhang,D.,
            Han,T., Yang,C.S., Cunningham,T.J., Head,S.R., Duester,G.,
            Dong,P.D. and Rana,T.M.
  TITLE     An evolutionarily conserved long noncoding RNA TUNA controls
            pluripotency and neural lineage commitment
  JOURNAL   Mol Cell 53 (6), 1005-1019 (2014)
   PUBMED   24530304
  REMARK    Erratum:[Mol Cell. 2014 Mar 20;53(6):1067]
REFERENCE   6  (bases 1 to 2905)
  AUTHORS   Liu,H., Zhang,W., Reed,R.B., Liu,W. and Grabowski,P.J.
  TITLE     Mutations in RRM4 uncouple the splicing repression and RNA-binding
            activities of polypyrimidine tract binding protein
  JOURNAL   RNA 8 (2), 137-149 (2002)
   PUBMED   11911361
  REMARK    GeneRIF: RRM RNA-binding domain role in RNA splicing
REFERENCE   7  (bases 1 to 2905)
  AUTHORS   Tillmar,L., Carlsson,C. and Welsh,N.
  TITLE     Control of insulin mRNA stability in rat pancreatic islets.
            Regulatory role of a 3'-untranslated region pyrimidine-rich
            sequence
  JOURNAL   J Biol Chem 277 (2), 1099-1106 (2002)
   PUBMED   11696543
REFERENCE   8  (bases 1 to 2905)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
REFERENCE   9  (bases 1 to 2905)
  AUTHORS   Jansen-Durr,P., Boshart,M., Lupp,B., Bosserhoff,A., Frank,R.W. and
            Schutz,G.
  TITLE     The rat poly pyrimidine tract binding protein (PTB) interacts with
            a single-stranded DNA motif in a liver-specific enhancer
  JOURNAL   Nucleic Acids Res 20 (6), 1243-1249 (1992)
   PUBMED   1561080
REFERENCE   10 (bases 1 to 2905)
  AUTHORS   Brunel,F., Alzari,P.M., Ferrara,P. and Zakin,M.M.
  TITLE     Cloning and sequencing of PYBP, a pyrimidine-rich specific single
            strand DNA-binding protein
  JOURNAL   Nucleic Acids Res 19 (19), 5237-5245 (1991)
   PUBMED   1681508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB772933.1 and BC061858.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061858.1, X74565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CB772933.1         11-15
            6-2905              BC061858.1         1-2900
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2905
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /note="polypyrimidine tract binding protein 1"
                     /db_xref="GeneID:29497"
                     /db_xref="RGD:62047"
     exon            1..72
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1735
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /note="isoform a is encoded by transcript variant 1;
                     heterogeneous nuclear ribonucleoprotein I; pyrimidine
                     binding protein 1; hnRNP I; pyrimidine binding protein 2"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 1 isoform
                     a"
                     /protein_id="NP_001257986.1"
                     /db_xref="GeneID:29497"
                     /db_xref="RGD:62047"
                     /translation="MDGIVPDIAVGTKRGSDELFSTCVSNGPFIMSSSASAANGNDSK
                     KFKGDNRSTGVPSRVIHVRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMST
                     EEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGN
                     LALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKN
                     NQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTR
                     PDLPSGDSQPSLDQTMAAAFGAPGIMSASPYAGAGFPPTFAIPQAAGLSVPNVHGALA
                     PLAIPSAAAAAAAAGRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRV
                     KILFNKKENALVQMADGSQAQLAMSHLNGHKLHGKSVRITLSKHQSVQLPREGQEDQG
                     LTKDYGSSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEDDLKSLFSSNGGVVKG
                     FKFFQKDRKMALIQMGSVEEAVQALIELHNHDLGENHHLRVSFSKSTI"
     exon            73..103
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            104..176
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            177..496
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..667
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..778
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            779..953
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1031
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1180
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1214
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1307
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1524
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1602
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..2890
                     /gene="Ptbp1"
                     /gene_synonym="Ptb; PTB1; Pybp; Pybp1; Pybp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgggtcgg tttctgctat tcctgcgcct ccgctccgtc ccctgcgggt ctcctctgtg
       61 tgccatggac ggcatcgtcc cagacatagc agtcggtaca aagcggggat ccgacgagct
      121 cttctccacg tgtgtcagca acggcccctt catcatgagc agctcggcct cagcagccaa
      181 cggaaatgat agcaagaagt tcaaaggtga taacaggagc acaggagttc cttccagagt
      241 catccatgtc cgaaagctac ctagtgatgt cactgagggc gaggtcatct ccctggggct
      301 gccctttggg aaagttacca acctccttat gctgaagggg aagaaccagg ccttcattga
      361 aatgagcaca gaggaggctg ccaacactat ggttaactac tacacatcgg tggcgccagt
      421 gcttcgtgga cagcccatct acatccagtt ctccaaccac aaggagctca aaaccgacag
      481 ctcgcccaac caggcacgtg cccaggcagc cctgcaggct gtgaactccg tacagtcagg
      541 aaacctggcc ttggcagcct ctgctgctgc cgtggatgca ggaatggcaa tggcaggcca
      601 gagcccagtg ctcaggatca ttgtggagaa ccttttctac ccagtgacac tggacgtgct
      661 gcaccagatc ttctcgaagt ttggcacagt cctgaagatc atcacgttca ccaagaacaa
      721 ccagttccag gcgctgctgc agtatgctga ccctgtgagc gcccagcatg ccaagctgtc
      781 cctggatggc cagaacatct acaatgcctg ctgcacgctg cgcatcgact tctccaagct
      841 caccagtctc aacgtcaaat acaacaacga caagagccga gactacacac gccctgacct
      901 gccctctgga gacagccagc catcactgga tcagaccatg gcagcagcct ttggtgcgcc
      961 cggcataatg tcagcctctc cgtatgcagg agccgggttc cctcccacct ttgccatccc
     1021 tcaggccgca ggcctctctg ttcctaatgt ccatggagcc ctggcacccc tggccatacc
     1081 ctctgctgct gctgctgctg ctgcagccgg ccgcattgcc atcccagggc tggcaggcgc
     1141 cgggaattcc gtccttttgg tcagcaactt gaaccctgag agagtcacac cccaaagcct
     1201 ctttattctc ttcggcgtct acggtgatgt gcagcgggtg aagatcctgt tcaacaagaa
     1261 ggagaacgca cttgtgcaga tggcagacgg cagccaggcc cagctggcca tgagccacct
     1321 gaacgggcac aagctgcatg ggaagtcagt gcgcatcacc ctgtcaaagc accagagtgt
     1381 gcagctgcct cgtgagggac aggaggacca gggcctgacc aaggactatg gcagctcacc
     1441 gctgcaccgc ttcaagaaac ctggctccaa gaactttcag aacatctttc ctccctcagc
     1501 taccctgcac ctctccaaca tcccgccctc tgtgtcagag gatgacctca agagcctctt
     1561 ctccagcaat ggcggtgtgg tcaaaggctt caagttcttc cagaaggacc gcaagatggc
     1621 actgatccag atgggctctg tggaggaggc agtgcaggca ctaattgagc tgcacaacca
     1681 tgacctgggc gagaaccacc acctgcgagt gtccttttcc aagtccacca tctaggtgcc
     1741 tgtgggcctg cgaaagcttc cgccattcca gaaaagccac tttaaaaagc agctgaagtg
     1801 accttacaga ccagagattt tattttttta aagagagatc agtttacctg tttttaaaaa
     1861 aattaaatct agcccacttt gccgtggcag gaaatggctt gggccacaga ggcccagtcc
     1921 cagcaaccat gccttgaggg gcttaggcgt gaggccacag cggtgccccg aacacagccg
     1981 ctttctgtgc cttacaaaac cagcgtgcct cacggccgca cacccaccct ctaaggccac
     2041 cagttgtctc tagacctgca gtgagccagg cggcctatac ttaggctccc caatgccgtg
     2101 taagagctgg ggccactccc ctacaccctt ataatcaagt gacatgattc tcccatgtcc
     2161 ctggccagcc cagagggccc aggccgtcct cagctgccga gccttgtgtg acctttgtat
     2221 tctattccgt ggggtcacag acacctgtgc ctagcaatct ttccacttga ccaaataccc
     2281 gagtcttttc catttatatg caagagatag agtttttaag taacttttta tagcagtggt
     2341 acaattgtat gtgtgtactc taagcttctc tgtcccctgc actccttcct tccagtgacc
     2401 aacttgcagg tgggcccagg ccagggctgg agaagaagct ctgaggcttg tgggtgtcct
     2461 accttcaaat tttggaccaa agttttgttc tctgcccgcc tctgactatg cccagttgag
     2521 gggctgacct ctaggcctta atgtccttcc tggacgccca cctccatcct agcctgtttc
     2581 tatgggaggg gttccctgca cctcagttct gtgaaagtca tggaagagtg taaatattta
     2641 tgattttata cctgtggggc tgaggcggtg cagcattttt tatggtgaca gatgtatatt
     2701 ttggtaacga ctacaggctc agtattgtcc tggggccagc cctggccaca tctaccccag
     2761 cccagatggt gtattggggg gagggggact ttccattaaa gcagttttat aacctttgcc
     2821 ttccctgagc ccttcattct gagctgtagg ccaggctggg cctggagtca ataaacaact
     2881 gtgtcttgca aaaaaaaaaa aaaaa
//
