LOCUS       NM_053321               3370 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus platelet-activating factor receptor (Ptafr),
            mRNA.
ACCESSION   NM_053321
VERSION     NM_053321.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Jin,J., Xu,F., Zhang,Y., Guan,J. and Fu,J.
  TITLE     Myocardial ischemia-reperfusion injury is probably due to the
            excessive production of mitochondrial ROS caused by the activation
            of 5-HT degradation system mediated by PAF receptor
  JOURNAL   Mol Immunol 155, 27-43 (2023)
   PUBMED   36682136
  REMARK    GeneRIF: Myocardial ischemia-reperfusion injury is probably due to
            the excessive production of mitochondrial ROS caused by the
            activation of 5-HT degradation system mediated by PAF receptor.
REFERENCE   2  (bases 1 to 3370)
  AUTHORS   Zhao,X.S., Ren,Y., Wu,Y., Ren,H.K. and Chen,H.
  TITLE     MiR-30b-5p and miR-22-3p restrain the fibrogenesis of
            post-myocardial infarction in mice via targeting PTAFR
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (7), 3993-4004 (2020)
   PUBMED   32329883
  REMARK    GeneRIF: MiR-30b-5p and miR-22-3p restrain the fibrogenesis of
            post-myocardial infarction in mice via targeting PTAFR.
REFERENCE   3  (bases 1 to 3370)
  AUTHORS   Kim,Y.H., Lee,S.J., Seo,K.W., Bae,J.U., Park,S.Y., Kim,E.K.,
            Bae,S.S., Kim,J.H. and Kim,C.D.
  TITLE     PAF enhances MMP-2 production in rat aortic VSMCs via a
            beta-arrestin2-dependent ERK signaling pathway
  JOURNAL   J Lipid Res 54 (10), 2678-2686 (2013)
   PUBMED   23911909
REFERENCE   4  (bases 1 to 3370)
  AUTHORS   Okubo,M., Yamanaka,H., Kobayashi,K., Kanda,H., Dai,Y. and
            Noguchi,K.
  TITLE     Up-regulation of platelet-activating factor synthases and its
            receptor in spinal cord contribute to development of neuropathic
            pain following peripheral nerve injury
  JOURNAL   Mol Pain 8, 8 (2012)
   PUBMED   22296727
  REMARK    GeneRIF: These data show the histological localization of PAF
            synthases and its receptor in the spinal cord following peripheral
            nerve injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3370)
  AUTHORS   Ji,R.L., Xia,S.H., Di,Y. and Xu,W.
  TITLE     Mechanism and dose-effect of Ginkgolide B on severe acute
            pancreatitis of rats
  JOURNAL   World J Gastroenterol 17 (17), 2241-2247 (2011)
   PUBMED   21633536
REFERENCE   6  (bases 1 to 3370)
  AUTHORS   Sugimoto,T., Tsuchimochi,H., McGregor,C.G., Mutoh,H., Shimizu,T.
            and Kurachi,Y.
  TITLE     Molecular cloning and characterization of the platelet-activating
            factor receptor gene expressed in the human heart
  JOURNAL   Biochem Biophys Res Commun 189 (2), 617-624 (1992)
   PUBMED   1281995
REFERENCE   7  (bases 1 to 3370)
  AUTHORS   Kunz,D., Gerard,N.P. and Gerard,C.
  TITLE     The human leukocyte platelet-activating factor receptor. cDNA
            cloning, cell surface expression, and construction of a novel
            epitope-bearing analog
  JOURNAL   J Biol Chem 267 (13), 9101-9106 (1992)
   PUBMED   1374385
REFERENCE   8  (bases 1 to 3370)
  AUTHORS   Hu,W.M. and Man,R.Y.
  TITLE     Differential actions of platelet-activating factor (PAF) receptor
            antagonists on the vasodilator and vasoconstrictor effects of PAF
            in the rat perfused heart
  JOURNAL   Br J Pharmacol 104 (4), 773-775 (1991)
   PUBMED   1667284
REFERENCE   9  (bases 1 to 3370)
  AUTHORS   Nakamura,M., Honda,Z., Izumi,T., Sakanaka,C., Mutoh,H., Minami,M.,
            Bito,H., Seyama,Y., Matsumoto,T., Noma,M. et al.
  TITLE     Molecular cloning and expression of platelet-activating factor
            receptor from human leukocytes
  JOURNAL   J Biol Chem 266 (30), 20400-20405 (1991)
   PUBMED   1657923
REFERENCE   10 (bases 1 to 3370)
  AUTHORS   Ye,R.D., Prossnitz,E.R., Zou,A.H. and Cochrane,C.G.
  TITLE     Characterization of a human cDNA that encodes a functional receptor
            for platelet activating factor
  JOURNAL   Biochem Biophys Res Commun 180 (1), 105-111 (1991)
   PUBMED   1656963
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072491.1.
            
            [WARNING] On Apr 26, 2024 this sequence was replaced by
            NM_053321.3.
            
            On Jun 13, 2004 this sequence version replaced NM_053321.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072491.1, U04740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3370
                     /gene="Ptafr"
                     /note="platelet-activating factor receptor"
                     /db_xref="GeneID:58949"
                     /db_xref="RGD:61897"
     exon            1..52
                     /gene="Ptafr"
                     /inference="alignment:Splign:2.1.0"
     exon            53..3314
                     /gene="Ptafr"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1124
                     /gene="Ptafr"
                     /note="PAF-R; PAFr"
                     /codon_start=1
                     /product="platelet-activating factor receptor"
                     /protein_id="NP_445773.1"
                     /db_xref="GeneID:58949"
                     /db_xref="RGD:61897"
                     /translation="MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLY
                     PSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTY
                     CSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNV
                     VPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPV
                     RQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQI
                     TLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQT
                     PVLPLKN"
ORIGIN      
        1 ctgaggcttg gacccggagg gacacgcaga gcctacggct gagctcctat agggacatac
       61 aacgttccat gaccaggtga cccttcctgc ccagagcaat ggagcaaaat ggctccttcc
      121 gtgtggattc tgagtttcga tacaccctct ttccgatcgt ttacagcgtc atctttgtac
      181 tgggcgtggt tgccaatggc tatgtgctgt gggtctttgc caccttgtac ccgtccaaga
      241 aactgaatga gataaagatc ttcatggtga atctcaccgt ggcggacctg ctcttcttga
      301 tgaccctccc gctgtggatt gtctattact ccaacgaggg cgactggatt gtacacaaat
      361 tcctgtgcaa cctggctggc tgcctcttct tcatcaatac ctactgcagt gtggccttcc
      421 ttggcgtcat cacttataac cgctaccagg cagtagccta tcccatcaag accgcccagg
      481 ccaccacccg caagcgtggc atcactttgt ccctggtcat ttggatatcc atcgcggcta
      541 ctgcatccta cttcctggcc acagactcta ccaacgtggt gcccaaaaag gatggctcag
      601 gtaacatcac ccgctgcttt gagcattatg agccatacag tgtgcccatc cttgtcgtcc
      661 acatcttcat cacctcctgt ttcttcctcg tcttcttcct catcttctac tgcaacatgg
      721 tcatcatcca cacgctgctc acgcggcctg tgcggcagca gcgcaaaccg gaagtgaagc
      781 gccgggcgct gtggatggtc tgcactgtct tggcggtatt tgtcatctgc tttgtgcccc
      841 atcacgtggt ccagctaccc tggaccctag cagagttggg ctaccagacc aacttccatc
      901 aggctattaa tgatgcccac caaatcaccc tctgcctcct gagcaccaac tgcgtcttag
      961 atcctgttat ctactgcttt ctcaccaaga agttccggaa gcacctcagc gaaaagtttt
     1021 acagcatgcg aagtagccgg aagtgctccc gagccactag cgacacgtgc accgaggtga
     1081 tgatgccagc caaccagact cctgtcctgc cattgaaaaa ttaatcaatg cttattaaag
     1141 ccaggtctag agccttctct tttatggccc ccaccgatgg cgcagaaagc taagaggttc
     1201 ctgcctgtgg ccaaccccca acttggaccc tggtggactc ttaagtgagg cagttacttc
     1261 ctcacagaga gccatttgct ggaaaataca gaactccaat gctccttttc atccatcctt
     1321 gagtcaacac tagagggttg tggctgatgg actcatccag ggcttcagat tgtgacaacc
     1381 ctgctagcac cagaccttgg ggagagacgc tgagcagccc agttcattca actgggacag
     1441 caatttaagg attgggcagt gacttccggg tgctacagga agaggggaga ggggttgtgg
     1501 ggactcttca ctgattgtga tctttggcaa aacaattggg tttaggatgg tgccttcctt
     1561 tatccatcta cagatacaag gtctttgtgg ctcttcctag aggaagtggt ttggtggtta
     1621 tcgcctgact cacccagcac cttgcctcag acataaccag aggagataac acagacgctg
     1681 accagaagct aggatgggtg catgtttgct gaggcagctg agttttgccc gggcctgagt
     1741 gagtgctgag ggaatggaag agaggtggct acctcagaac actgcacttt ccacttccgg
     1801 caggcagctt cttttgaggt cctctggcca cctggtggtg attttttgac aagtgtctta
     1861 gtctcatttc actcaccgtg cccagaaaac aactcgagga gggagagatt tattttggct
     1921 cacagtttgg aggacctcag tccctcacgg caaggaaggc atggtggggc tcagactctg
     1981 gtggtgggaa taggagacgg aggttgtcca cgtggcagtg agccaggaac caagactgca
     2041 ccttaaccca gggttgggat ataacccacg cccccgcgcc cccagccacc tacttctaca
     2101 gccaggtcct acctcctcct aaaggttcca cagtctcccg acctagagag cacggccctg
     2161 ggccagtgag atggtcgtgg agggtagaga gcacttgcag ctaacactgc tgatcagagt
     2221 ttgatcccag aagccacatg gtacaaagag agaacagatt tctgcaagtt gtcctttgac
     2281 ctttgctttc atgctgcggc acacacatgt cccgcctccc ccatatacat ataaataaat
     2341 gtacaaaatt aataggataa agcaaaacga atatgacccc ataggagtat acatgaaacg
     2401 gcaggtgtat tcaaaacata cctgctattt catttaagtg agatcccccc cggccctctg
     2461 agaagtatcc agaagcctca gactcagaac tctgaggacc ttttcctgtt ttcctgagcc
     2521 ttgtgctttc gagtgtctcc ttgaagctgg gtcaattgct tcctgtctgc tagacaagca
     2581 taggcttgtt ccaacggaca agcttgagtt tggaatgatg acggcagtct ggatctagct
     2641 gaaggggaca aagtggctaa aacaacttga acttcgtaga catcttacaa acccgggttc
     2701 aagtcttgcc tgtgctgaat gttgcttagg acgtgggaat ataattttct acctcttggt
     2761 gttgttagct gggaggttca acctacctca cgggacttct gggcagtgcg tgttcagctg
     2821 actctgggct atttatccct atcctcccct ttgctgggaa tttggtgccc tcgatccttg
     2881 gtttagaact gaaggggtga gggttagatg tctggatgcg gggtgcacct tttggggagc
     2941 tgtgaccatg tttacatgtg aagtgggttg ggtggccacc taggtgactg gtagatagaa
     3001 gtggcttttc aaagaaatca ggttagacca gacagaagct agaacgtggc gagaacactc
     3061 agcttcagag gggccagcag gcacgtcccc ggtgctttct cttgcgtccc gggaggttct
     3121 tgtcaggatt ccttctctct ccttccctaa gctcattgaa atggttgtct agtgctttca
     3181 atcaaataac atcctctgcc tctgtgttaa tatgatatag tctgaatttc atcgtctgca
     3241 aatctccctt gccactggtt tgcaatatcc atttaccaca gtaggtttgc ttaataaaca
     3301 tttttctctt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3361 aaaaaaaaaa
//
