LOCUS       NM_013014                755 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus persephin (Pspn), mRNA.
ACCESSION   NM_013014
VERSION     NM_013014.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 755)
  AUTHORS   Sidorova,Y.A., Matlik,K., Paveliev,M., Lindahl,M., Piranen,E.,
            Milbrandt,J., Arumae,U., Saarma,M. and Bespalov,M.M.
  TITLE     Persephin signaling through GFRalpha1: the potential for the
            treatment of Parkinson's disease
  JOURNAL   Mol Cell Neurosci 44 (3), 223-232 (2010)
   PUBMED   20350599
  REMARK    GeneRIF: Results identify persephin, a GDNF family member, as a
            novel ligand for GFRalpha1/RET receptor complex.
REFERENCE   2  (bases 1 to 755)
  AUTHORS   Zihlmann,K.B., Ducray,A.D., Schaller,B., Huber,A.W., Krebs,S.H.,
            Andres,R.H., Seiler,R.W., Meyer,M. and Widmer,H.R.
  TITLE     The GDNF family members neurturin, artemin and persephin promote
            the morphological differentiation of cultured ventral mesencephalic
            dopaminergic neurons
  JOURNAL   Brain Res Bull 68 (1-2), 42-53 (2005)
   PUBMED   16325003
  REMARK    GeneRIF: PSPN acts potent neurotrophic factor that may play an
            important role in the structural development and plasticity of
            ventral mesencephalic dopaminergic neurons
REFERENCE   3  (bases 1 to 755)
  AUTHORS   Akerud,P., Holm,P.C., Castelo-Branco,G., Sousa,K., Rodriguez,F.J.
            and Arenas,E.
  TITLE     Persephin-overexpressing neural stem cells regulate the function of
            nigral dopaminergic neurons and prevent their degeneration in a
            model of Parkinson's disease
  JOURNAL   Mol Cell Neurosci 21 (2), 205-222 (2002)
   PUBMED   12401443
  REMARK    GeneRIF: PSP promotes the survival and neurite outgrowth of
            midbrain dopamine neurons in vitro as potently and efficiently as
            GDNF.
REFERENCE   4  (bases 1 to 755)
  AUTHORS   Stover,T., Gong,T.L., Cho,Y., Altschuler,R.A. and Lomax,M.I.
  TITLE     Expression of the GDNF family members and their receptors in the
            mature rat cochlea
  JOURNAL   Brain Res Mol Brain Res 76 (1), 25-35 (2000)
   PUBMED   10719212
REFERENCE   5  (bases 1 to 755)
  AUTHORS   Jaszai,J., Farkas,L., Galter,D., Reuss,B., Strelau,J., Unsicker,K.
            and Krieglstein,K.
  TITLE     GDNF-related factor persephin is widely distributed throughout the
            nervous system
  JOURNAL   J Neurosci Res 53 (4), 494-501 (1998)
   PUBMED   9710270
REFERENCE   6  (bases 1 to 755)
  AUTHORS   Milbrandt,J., de Sauvage,F.J., Fahrner,T.J., Baloh,R.H.,
            Leitner,M.L., Tansey,M.G., Lampe,P.A., Heuckeroth,R.O.,
            Kotzbauer,P.T., Simburger,K.S., Golden,J.P., Davies,J.A.,
            Vejsada,R., Kato,A.C., Hynes,M., Sherman,D., Nishimura,M.,
            Wang,L.C., Vandlen,R., Moffat,B., Klein,R.D., Poulsen,K., Gray,C.,
            Garces,A., Johnson,E.M. Jr. et al.
  TITLE     Persephin, a novel neurotrophic factor related to GDNF and
            neurturin
  JOURNAL   Neuron 20 (2), 245-253 (1998)
   PUBMED   9491986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000204.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_013014.3.
            
            On Oct 11, 2022 this sequence version replaced NM_013014.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF040961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               JACYVU010000204.1  1589199-1589437     c
            240-755             JACYVU010000204.1  1588595-1589110     c
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..755
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /note="persephin"
                     /db_xref="GeneID:25525"
                     /db_xref="RGD:3432"
     exon            1..239
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..556
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /codon_start=1
                     /product="persephin precursor"
                     /protein_id="NP_037146.1"
                     /db_xref="GeneID:25525"
                     /db_xref="RGD:3432"
                     /translation="MAAGRLRILFLLLLSLHLGLGWVLDLQEAPAADELSSGKMAETG
                     RTWKPHQGNNNVRLPRALPGLCRLWSLTLPVAELGLGYASEEKIIFRYCAGSCPQEVR
                     TQHSLVLARLRGQGRAHGRPCCQPTSYADVTFLDDHHHWQQLPQLSAAACGCGG"
     exon            240..755
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaagtgat tttaatcccc aggacaggca gggaataaat tgagggcacc aaagcctctc
       61 ggcatcctgg gacctgcctg tcacaatggc tgcaggaaga cttcggatct tgtttctgct
      121 gctcctgtcc ttgcacctgg gccttggctg ggtccttgat cttcaagagg ctcctgcggc
      181 agatgagctc tcatctggga aaatggcaga gactggaagg acctggaagc cccatcaggg
      241 taacaacaat gtccgccttc caagagcctt acctggtttg tgccggctgt ggagcctgac
      301 cctaccagtg gctgagcttg gcctgggcta tgcctcagag gagaagatta tcttccgata
      361 ctgtgctggc agctgtcccc aagaggtccg tacccagcac agtctggtgc tggcccgtct
      421 tcgagggcag ggtcgagctc atggcagacc ttgctgccag cccaccagct atgctgatgt
      481 gaccttcctt gatgaccacc accattggca gcagctgcct cagctctcag ccgcagcttg
      541 tggctgtggt ggctgaaggc ggccagcctg gtctctcaga atcacaagca agaggcagcc
      601 tttgaaaggc tcaggtgacg ttattagaaa cttgcatagg agaagattaa gaagagaaag
      661 gggacctggg gtttggtttt tttttttttt tttttttttt tttgcttgtt ttctatcagt
      721 agtgaatgca ataaacgata ttcttatggt cttaa
//
