LOCUS       NP_037146                156 aa            linear   ROD 03-APR-2024
DEFINITION  persephin precursor [Rattus norvegicus].
ACCESSION   NP_037146
VERSION     NP_037146.1
DBSOURCE    REFSEQ: accession NM_013014.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 156)
  AUTHORS   Sidorova,Y.A., Matlik,K., Paveliev,M., Lindahl,M., Piranen,E.,
            Milbrandt,J., Arumae,U., Saarma,M. and Bespalov,M.M.
  TITLE     Persephin signaling through GFRalpha1: the potential for the
            treatment of Parkinson's disease
  JOURNAL   Mol Cell Neurosci 44 (3), 223-232 (2010)
   PUBMED   20350599
  REMARK    GeneRIF: Results identify persephin, a GDNF family member, as a
            novel ligand for GFRalpha1/RET receptor complex.
REFERENCE   2  (residues 1 to 156)
  AUTHORS   Zihlmann,K.B., Ducray,A.D., Schaller,B., Huber,A.W., Krebs,S.H.,
            Andres,R.H., Seiler,R.W., Meyer,M. and Widmer,H.R.
  TITLE     The GDNF family members neurturin, artemin and persephin promote
            the morphological differentiation of cultured ventral mesencephalic
            dopaminergic neurons
  JOURNAL   Brain Res Bull 68 (1-2), 42-53 (2005)
   PUBMED   16325003
  REMARK    GeneRIF: PSPN acts potent neurotrophic factor that may play an
            important role in the structural development and plasticity of
            ventral mesencephalic dopaminergic neurons
REFERENCE   3  (residues 1 to 156)
  AUTHORS   Akerud,P., Holm,P.C., Castelo-Branco,G., Sousa,K., Rodriguez,F.J.
            and Arenas,E.
  TITLE     Persephin-overexpressing neural stem cells regulate the function of
            nigral dopaminergic neurons and prevent their degeneration in a
            model of Parkinson's disease
  JOURNAL   Mol Cell Neurosci 21 (2), 205-222 (2002)
   PUBMED   12401443
  REMARK    GeneRIF: PSP promotes the survival and neurite outgrowth of
            midbrain dopamine neurons in vitro as potently and efficiently as
            GDNF.
REFERENCE   4  (residues 1 to 156)
  AUTHORS   Stover,T., Gong,T.L., Cho,Y., Altschuler,R.A. and Lomax,M.I.
  TITLE     Expression of the GDNF family members and their receptors in the
            mature rat cochlea
  JOURNAL   Brain Res Mol Brain Res 76 (1), 25-35 (2000)
   PUBMED   10719212
REFERENCE   5  (residues 1 to 156)
  AUTHORS   Jaszai,J., Farkas,L., Galter,D., Reuss,B., Strelau,J., Unsicker,K.
            and Krieglstein,K.
  TITLE     GDNF-related factor persephin is widely distributed throughout the
            nervous system
  JOURNAL   J Neurosci Res 53 (4), 494-501 (1998)
   PUBMED   9710270
REFERENCE   6  (residues 1 to 156)
  AUTHORS   Milbrandt,J., de Sauvage,F.J., Fahrner,T.J., Baloh,R.H.,
            Leitner,M.L., Tansey,M.G., Lampe,P.A., Heuckeroth,R.O.,
            Kotzbauer,P.T., Simburger,K.S., Golden,J.P., Davies,J.A.,
            Vejsada,R., Kato,A.C., Hynes,M., Sherman,D., Nishimura,M.,
            Wang,L.C., Vandlen,R., Moffat,B., Klein,R.D., Poulsen,K., Gray,C.,
            Garces,A., Johnson,E.M. Jr. et al.
  TITLE     Persephin, a novel neurotrophic factor related to GDNF and
            neurturin
  JOURNAL   Neuron 20 (2), 245-253 (1998)
   PUBMED   9491986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF040961.1, SRR26360172.2007380.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..156
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     Protein         1..156
                     /product="persephin precursor"
                     /calculated_mol_wt=14803
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2278
     mat_peptide     22..156
                     /product="Persephin. /id=PRO_0000034016"
                     /note="propagated from UniProtKB/Swiss-Prot (O70301.1)"
                     /calculated_mol_wt=14803
     Region          66..156
                     /region_name="TGF_beta_Persephin"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in Persephin and similar proteins; cd19382"
                     /db_xref="CDD:381652"
     Site            order(71,73,77..80,90..94,104..106,108..109,111..112,
                     120..126,129,145..147)
                     /site_type="other"
                     /note="putative homodimer interface [polypeptide binding]"
                     /db_xref="CDD:381652"
     Site            order(72,85..87,89,131..135,137,139..141,143)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:381652"
     CDS             1..156
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /coded_by="NM_013014.3:86..556"
                     /db_xref="GeneID:25525"
                     /db_xref="RGD:3432"
ORIGIN      
        1 maagrlrilf llllslhlgl gwvldlqeap aadelssgkm aetgrtwkph qgnnnvrlpr
       61 alpglcrlws ltlpvaelgl gyaseekiif rycagscpqe vrtqhslvla rlrgqgrahg
      121 rpccqptsya dvtflddhhh wqqlpqlsaa acgcgg
//
