LOCUS       NM_001009679            1166 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphoserine phosphatase (Psph), mRNA.
ACCESSION   NM_001009679 XM_222105
VERSION     NM_001009679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1166)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1166)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1166)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1166)
  AUTHORS   Wang,Y., Maciejewski,B.S., Weissmann,G., Silbert,O., Han,H. and
            Sanchez-Esteban,J.
  TITLE     DNA microarray reveals novel genes induced by mechanical forces in
            fetal lung type II epithelial cells
  JOURNAL   Pediatr Res 60 (2), 118-124 (2006)
   PUBMED   16864689
REFERENCE   5  (bases 1 to 1166)
  AUTHORS   Peeraer,Y., Rabijns,A., Collet,J.F., Van Schaftingen,E. and De
            Ranter,C.
  TITLE     How calcium inhibits the magnesium-dependent enzyme human
            phosphoserine phosphatase
  JOURNAL   Eur J Biochem 271 (16), 3421-3427 (2004)
   PUBMED   15291819
REFERENCE   6  (bases 1 to 1166)
  AUTHORS   Peeraer,Y., Rabijns,A., Verboven,C., Collet,J.F., Van
            Schaftingen,E. and De Ranter,C.
  TITLE     High-resolution structure of human phosphoserine phosphatase in
            open conformation
  JOURNAL   Acta Crystallogr D Biol Crystallogr 59 (Pt 6), 971-977 (2003)
   PUBMED   12777757
REFERENCE   7  (bases 1 to 1166)
  AUTHORS   Wood,P.L., Hawkinson,J.E. and Goodnough,D.B.
  TITLE     Formation of D-serine from L-phosphoserine in brain synaptosomes
  JOURNAL   J Neurochem 67 (4), 1485-1490 (1996)
   PUBMED   8858931
REFERENCE   8  (bases 1 to 1166)
  AUTHORS   Guynn,R.W., Merrill,D.K. and Lund,K.
  TITLE     The reactions of the phosphorylated pathway of L-serine
            biosynthesis: thermodynamic relationships in rat liver in vivo
  JOURNAL   Arch Biochem Biophys 245 (1), 204-211 (1986)
   PUBMED   3004357
REFERENCE   9  (bases 1 to 1166)
  AUTHORS   Brass,C.A., Isaacs,C.E., McChesney,R. and Greengard,O.
  TITLE     The effects of hyperphenylalaninemia on fetal development: a new
            animal model of maternal phenylketonuria
  JOURNAL   Pediatr Res 16 (5), 388-394 (1982)
   PUBMED   7201630
REFERENCE   10 (bases 1 to 1166)
  AUTHORS   Sanborn,T.A., Kowle,R.L. and Sallach,H.J.
  TITLE     Regulation of enzymes of serine and one-carbon metabolism by
            testosterone in rat prostate, liver, and kidney
  JOURNAL   Endocrinology 97 (4), 1000-1007 (1975)
   PUBMED   172314
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088310.1.
            
            On Jan 13, 2005 this sequence version replaced XM_222105.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088310.1, FQ213675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1166
                     /gene="Psph"
                     /note="phosphoserine phosphatase"
                     /db_xref="GeneID:304429"
                     /db_xref="RGD:1308764"
     exon            1..216
                     /gene="Psph"
                     /inference="alignment:Splign:2.1.0"
     exon            217..375
                     /gene="Psph"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..913
                     /gene="Psph"
                     /EC_number="3.1.3.3"
                     /note="PSP; PSPase; O-phosphoserine phosphohydrolase"
                     /codon_start=1
                     /product="phosphoserine phosphatase"
                     /protein_id="NP_001009679.1"
                     /db_xref="GeneID:304429"
                     /db_xref="RGD:1308764"
                     /translation="MVSHSELRKLFCSADAVCFDVDSTVIREEGIDELAKFCGVEAAV
                     SEMTRRAMGGALPFKDALTERLALIQPSRDQVQRLLAEHPPHLTPGIRELVSRLQERN
                     VQVFLISGGFRSIVEHVAAKLNIPTTNVFANRLKFYFNGEYAGFDETQPTAESGGKGK
                     VIGFLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVE
                     LLGELEE"
     exon            376..510
                     /gene="Psph"
                     /inference="alignment:Splign:2.1.0"
     exon            511..656
                     /gene="Psph"
                     /inference="alignment:Splign:2.1.0"
     exon            657..805
                     /gene="Psph"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1142
                     /gene="Psph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttctcca gttggaagca cacatgccaa actgctctgg agacgccgga ggcatcggca
       61 gatcccagac gagcgttgag tgaaggctgt gatctgcctt accggtcacc tcactcagga
      121 cacagcgctc gcacgttgca gcagctccag accccactac taccggaaag ttacaggtac
      181 cggaaccaag aagaccagcg cggcccagga acagcggagg aaaactcttc ccaggatggt
      241 ctcccactca gagctgagga agctcttctg ttcggctgat gcagtgtgct ttgatgttga
      301 tagcacagtc atcagagaag agggaatcga tgagctggcc aaattctgtg gtgtggaggc
      361 tgcagtgtct gaaatgacac ggagagccat gggaggagcg ttgcctttca aagatgcgct
      421 cactgagcgc ctggcactga tccagccctc cagggatcag gtgcagaggc tgctggctga
      481 acacccgcca cacctgaccc cggggataag ggagctggta agccgcctcc aggagcggaa
      541 tgttcaggtg ttcctcatct ccgggggctt taggagtatt gtggagcacg ttgctgcaaa
      601 gctcaacatc cccacaacca atgtctttgc caataggctg aaattctact tcaacggtga
      661 gtacgcaggt tttgacgaga cgcagccgac agccgagtca ggtgggaaag gaaaggttat
      721 tggattttta aaggaaaaat ttcactttaa gaaaataatc atgattggag acggagccac
      781 agacatggaa gcctgccctc ccgctgatgc cttcattggc tttggaggca acgtgatcag
      841 gcagcaggtt aaggacaatg ccaagtggta catcactgac tttgttgaac tgctaggaga
      901 actggaagaa tgatctggac ttcccggtca ctcagaacaa ctccaccttc tcgacgctac
      961 acagttgggc tcctggaaga gtctaggaga cagctatttt tttctactgt agttccaata
     1021 ttaatatgac tactaattac atggagagtt ttatattctg aattctttgt gtatattcct
     1081 cggaatattt tacctggagc tttctgaggt gcatagtaaa ttaaatgcct ttactcttgc
     1141 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
