LOCUS       NM_017257               1366 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus proteasome activator subunit 2 (Psme2), mRNA.
ACCESSION   NM_017257
VERSION     NM_017257.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1366)
  AUTHORS   Wu,D.G., Wang,Y.N., Zhou,Y., Gao,H. and Zhao,B.
  TITLE     Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized
            Protein Overload in the Diabetic Rat Brain
  JOURNAL   Cell Mol Neurobiol 43 (6), 2857-2869 (2023)
   PUBMED   36715894
  REMARK    GeneRIF: Inhibition of the Proteasome Regulator PA28 Aggravates
            Oxidized Protein Overload in the Diabetic Rat Brain.
REFERENCE   2  (bases 1 to 1366)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1366)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1366)
  AUTHORS   Ossendorp,F., Fu,N., Camps,M., Granucci,F., Gobin,S.J., van den
            Elsen,P.J., Schuurhuis,D., Adema,G.J., Lipford,G.B., Chiba,T.,
            Sijts,A., Kloetzel,P.M., Ricciardi-Castagnoli,P. and Melief,C.J.
  TITLE     Differential expression regulation of the alpha and beta subunits
            of the PA28 proteasome activator in mature dendritic cells
  JOURNAL   J Immunol 174 (12), 7815-7822 (2005)
   PUBMED   15944286
REFERENCE   5  (bases 1 to 1366)
  AUTHORS   Ahn,J.Y., Tanahashi,N., Akiyama,K., Hisamatsu,H., Noda,C.,
            Tanaka,K., Chung,C.H., Shibmara,N., Willy,P.J., Mott,J.D. et al.
  TITLE     Primary structures of two homologous subunits of PA28, a
            gamma-interferon-inducible protein activator of the 20S proteasome
  JOURNAL   FEBS Lett 366 (1), 37-42 (1995)
   PUBMED   7789512
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097331.1.
            
            On Jun 19, 2005 this sequence version replaced NM_017257.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097331.1, EV764390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1366
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1366
                     /gene="Psme2"
                     /note="proteasome activator subunit 2"
                     /db_xref="GeneID:29614"
                     /db_xref="RGD:3430"
     exon            1..50
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..719
                     /gene="Psme2"
                     /note="protease (prosome, macropain) 28 subunit, beta;
                     PA28b; PA28beta; REG-beta; 11S regulator complex subunit
                     beta; proteasome activator 28 subunit beta; activator of
                     multicatalytic protease subunit 2; proteasome (prosome,
                     macropain) 28 subunit, beta; proteasome (prosome,
                     macropain) activator subunit 2"
                     /codon_start=1
                     /product="proteasome activator complex subunit 2"
                     /protein_id="NP_058953.1"
                     /db_xref="GeneID:29614"
                     /db_xref="RGD:3430"
                     /translation="MAKPCGVRLSGEARKQVDAFRQNLFQEAEDFLCTFLPRKIISLS
                     QLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETEQEKKEVPKCGFLPGNEKLLAL
                     LALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQ
                     TAISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELHHI
                     ISSNLEKIVNPKGEEKPSMY"
     exon            51..83
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            84..146
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..233
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            234..261
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..359
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..428
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..496
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..551
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..638
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..1343
                     /gene="Psme2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatggccaa gccttgtggg gttcgcttga gtggagaagc ccgtaaacag gtggatgcct
       61 tcagacaaaa tcttttccag gaggctgagg acttcctttg cactttcttg ccacggaaaa
      121 tcatatccct gagtcagctc ttgcaagagg attccctcaa tgtggctgac ctctcctccc
      181 tccgggctcc tctggacatc cctatcccag atcccccacc caaggatgat gagatggaaa
      241 ccgagcagga gaagaaagaa gtccctaagt gtggcttcct ccctgggaat gagaagcttc
      301 tggccctgct tgccttggtt aagccagaag tctggactct caaagagaag tgcattctgg
      361 taatcacatg gatccagcac ctgatcccca agattgagga cggaaatgat tttggggtgg
      421 caattcagga gaaggtgctg gagagagtga atgctgtcaa gaccaaagtg gaagccttcc
      481 agacagccat ctccaagtat ttctcagagc gtggggatgc tgtagccaag gcctccaagg
      541 acacccatgt aatggattac cgggccttgg tgcacgagcg agatgaagca gcctatgggg
      601 cgcttagggc catggtgctg gacctgagag ccttctatgc tgagcttcat cacatcatca
      661 gcagcaacct agagaaaatt gtcaacccaa agggtgaaga aaagccatct atgtactgag
      721 caaaggatta gaaggaaaat aaatgattta tactttatgt atattacctc tgtcgttcat
      781 tgagagagca tttatcgagg gcctccattg tctccatggt aatgaatacg gtgatgaacg
      841 tgggagaggg ttggctggag ggatggctca gcagttaaga gcactggctg ttcttccaga
      901 gggacccagg ctccaattcc cagcacccag aagatgacta ataactctgt aactccagtt
      961 ccaggggatc tggacaccct cttctgacct ctacagacac cagatatgca catatgatgt
     1021 ccacgcaaat gtgcaagcaa aacactcatc acataaagca aaaacaaaaa aaagttgaaa
     1081 gattaagtgg gggagggttc taggaagtcg aggatgggct tgaggcccat tgtgtttttc
     1141 acagatcatt ctaaagaatg gggtaggggc tggagaaatg gctcagtggt taaaaacact
     1201 gactgctcat cctaaggtcc tgagttcaaa tcccagcaac cacatggtgg ctcacaacca
     1261 actgtaatga gatctgatgc cctcttctgc tgtgtctgaa gacagctaca gtgtacttat
     1321 aaataaataa atatttttaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
