LOCUS       NM_017264               1030 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus proteasome activator subunit 1 (Psme1), mRNA.
ACCESSION   NM_017264
VERSION     NM_017264.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1030)
  AUTHORS   Wu,D.G., Wang,Y.N., Zhou,Y., Gao,H. and Zhao,B.
  TITLE     Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized
            Protein Overload in the Diabetic Rat Brain
  JOURNAL   Cell Mol Neurobiol 43 (6), 2857-2869 (2023)
   PUBMED   36715894
  REMARK    GeneRIF: Inhibition of the Proteasome Regulator PA28 Aggravates
            Oxidized Protein Overload in the Diabetic Rat Brain.
REFERENCE   2  (bases 1 to 1030)
  AUTHORS   Li,J., Powell,S.R. and Wang,X.
  TITLE     Enhancement of proteasome function by PA28&alpha; overexpression
            protects against oxidative stress
  JOURNAL   FASEB J 25 (3), 883-893 (2011)
   PUBMED   21098724
  REMARK    GeneRIF: PA28alphaOE is sufficient to up-regulate 11S proteasomes,
            enhance proteasome-mediated removal of misfolded and oxidized
            proteins, and protect against oxidative stress in cardiomyocytes
REFERENCE   3  (bases 1 to 1030)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1030)
  AUTHORS   Ossendorp,F., Fu,N., Camps,M., Granucci,F., Gobin,S.J., van den
            Elsen,P.J., Schuurhuis,D., Adema,G.J., Lipford,G.B., Chiba,T.,
            Sijts,A., Kloetzel,P.M., Ricciardi-Castagnoli,P. and Melief,C.J.
  TITLE     Differential expression regulation of the alpha and beta subunits
            of the PA28 proteasome activator in mature dendritic cells
  JOURNAL   J Immunol 174 (12), 7815-7822 (2005)
   PUBMED   15944286
REFERENCE   5  (bases 1 to 1030)
  AUTHORS   Ahn,J.Y., Tanahashi,N., Akiyama,K., Hisamatsu,H., Noda,C.,
            Tanaka,K., Chung,C.H., Shibmara,N., Willy,P.J., Mott,J.D. et al.
  TITLE     Primary structures of two homologous subunits of PA28, a
            gamma-interferon-inducible protein activator of the 20S proteasome
  JOURNAL   FEBS Lett 366 (1), 37-42 (1995)
   PUBMED   7789512
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060574.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017264.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060574.1, FQ226855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1030              BC060574.1         5-1034
FEATURES             Location/Qualifiers
     source          1..1030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1030
                     /gene="Psme1"
                     /note="proteasome activator subunit 1"
                     /db_xref="GeneID:29630"
                     /db_xref="RGD:3429"
     exon            1..147
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..858
                     /gene="Psme1"
                     /note="protease (prosome, macropain) 28 subunit, alpha;
                     PA28a; PA28alpha; REG-alpha; 11S regulator complex subunit
                     alpha; proteasome activator 28 subunit alpha; activator of
                     multicatalytic protease subunit 1; proteasome (prosome,
                     macropain) 28 subunit, alpha; proteasome (prosome,
                     macropain) activator subunit 1"
                     /codon_start=1
                     /product="proteasome activator complex subunit 1"
                     /protein_id="NP_058960.2"
                     /db_xref="GeneID:29630"
                     /db_xref="RGD:3429"
                     /translation="MATLRVHPEAQAKVDVFREDLCSKTENLLGSYFPKKISELDAFL
                     KEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEEKDEKKKGDEDDKGPPCG
                     PVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELM
                     TSLHTKLEGFQTQISKYFSERGDAVAKAAKQPHVGDYRQLVHELDEAEYQEIRLMVME
                     IRNAYAVLYDIILKNFEKLKKPRGETKGMIY"
     exon            148..180
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..243
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..354
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..400
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..498
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..567
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..635
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..690
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..777
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1000
                     /gene="Psme1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccccaaa cccaggaagg cggtgcaggt ttcgagctgt gctttcgctt tcccttcccg
       61 ctgcccaccc caggctccgc gtgcggcgtt cagcccccgg ctctggccat ggctacactg
      121 agggtccatc ctgaagccca agccaaggtg gatgtgtttc gtgaggacct gtgtagtaag
      181 acagagaacc tgcttgggag ctattttccc aagaagatct cagagttgga tgccttctta
      241 aaggagccag ctctcaacga agccaacctg agcaatctga aggctccatt ggacatccca
      301 gtccctgatc ccgtcaagga gaaagagaag gaggagcgga agaagcaaca ggagaaggaa
      361 gagaaggacg aaaagaagaa aggggacgaa gacgacaaag gtcctccctg tggtccagtg
      421 aactgcaatg agaagattgt ggtcctcctg caacgcctaa agcccgagat caaggatgtc
      481 attgagcaac tcaacctggt tactacctgg ttgcagctac agatacctcg gatagaggat
      541 gggaataatt ttggcgtggc tgtccaggaa aaggtgtttg agctgatgac cagccttcat
      601 accaagctgg aaggcttcca aacgcagatc tctaagtact tctccgagag gggtgatgcc
      661 gtggccaaag cagccaagca gcctcatgtg ggtgattatc ggcagctggt gcatgagctg
      721 gacgaggcgg aataccagga gatccggctg atggtcatgg agatccgtaa cgcttatgct
      781 gtgttatatg acatcatcct gaagaacttt gagaagctca agaagccccg tggagagaca
      841 aaggggatga tctattgagc cccctctctc gttctatgat gggtataaca gaaaccttcc
      901 tactcttgac taggaactct agactgcacc cagtcttctt cctgctgggg tctcctccct
      961 cactctgcct tccaaacaca ataaatacat agttgcccac aaaaaaaaaa aaaaaaaaaa
     1021 aaaaaaaaaa
//
