LOCUS       NM_031978               3227 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus proteasome 26S subunit, non-ATPase 1 (Psmd1),
            mRNA.
ACCESSION   NM_031978
VERSION     NM_031978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3227)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3227)
  AUTHORS   Ge,P., Luo,Y., Liu,C.L. and Hu,B.
  TITLE     Protein aggregation and proteasome dysfunction after brain ischemia
  JOURNAL   Stroke 38 (12), 3230-3236 (2007)
   PUBMED   17975104
  REMARK    GeneRIF: analysis of proteasome 19 and 26 dysfunction after brain
            ischemia
REFERENCE   3  (bases 1 to 3227)
  AUTHORS   Yi,H., Friedman,J.L. and Ferreira,P.A.
  TITLE     The cyclophilin-like domain of Ran-binding protein-2 modulates
            selectively the activity of the ubiquitin-proteasome system and
            protein biogenesis
  JOURNAL   J Biol Chem 282 (48), 34770-34778 (2007)
   PUBMED   17911097
REFERENCE   4  (bases 1 to 3227)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   5  (bases 1 to 3227)
  AUTHORS   Stanhill,A., Haynes,C.M., Zhang,Y., Min,G., Steele,M.C.,
            Kalinina,J., Martinez,E., Pickart,C.M., Kong,X.P. and Ron,D.
  TITLE     An arsenite-inducible 19S regulatory particle-associated protein
            adapts proteasomes to proteotoxicity
  JOURNAL   Mol Cell 23 (6), 875-885 (2006)
   PUBMED   16973439
REFERENCE   6  (bases 1 to 3227)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 3227)
  AUTHORS   Arndt,V., Daniel,C., Nastainczyk,W., Alberti,S. and Hohfeld,J.
  TITLE     BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin
            ligase CHIP
  JOURNAL   Mol Biol Cell 16 (12), 5891-5900 (2005)
   PUBMED   16207813
REFERENCE   8  (bases 1 to 3227)
  AUTHORS   Butts,B.D., Hudson,H.R., Linseman,D.A., Le,S.S., Ryan,K.R.,
            Bouchard,R.J. and Heidenreich,K.A.
  TITLE     Proteasome inhibition elicits a biphasic effect on neuronal
            apoptosis via differential regulation of pro-survival and
            pro-apoptotic transcription factors
  JOURNAL   Mol Cell Neurosci 30 (2), 279-289 (2005)
   PUBMED   16112871
  REMARK    GeneRIF: Proteasome inhibition exerts an acute pro-survival action
            by stabilizing transcription factors.
REFERENCE   9  (bases 1 to 3227)
  AUTHORS   Seidel,B., Keilhoff,G., Reinheckel,T. and Wolf,G.
  TITLE     Differentially expressed genes in hippocampal cell cultures in
            response to an excitotoxic insult by quinolinic acid
  JOURNAL   Brain Res Mol Brain Res 60 (2), 296-300 (1998)
   PUBMED   9757068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 30, 2020 this sequence version replaced NM_031978.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ006340.1, SRR26360194.2133335.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000009.1  94157971-94158127
            158-201             JAXUCZ010000009.1  94163836-94163879
            202-275             JAXUCZ010000009.1  94165073-94165146
            276-445             JAXUCZ010000009.1  94165288-94165457
            446-651             JAXUCZ010000009.1  94167354-94167559
            652-795             JAXUCZ010000009.1  94169243-94169386
            796-1022            JAXUCZ010000009.1  94170838-94171064
            1023-1083           JAXUCZ010000009.1  94174196-94174256
            1084-1212           JAXUCZ010000009.1  94175266-94175394
            1213-1301           JAXUCZ010000009.1  94177095-94177183
            1302-1380           JAXUCZ010000009.1  94177926-94178004
            1381-1554           JAXUCZ010000009.1  94178472-94178645
            1555-1666           JAXUCZ010000009.1  94180959-94181070
            1667-1863           JAXUCZ010000009.1  94182193-94182389
            1864-1959           JAXUCZ010000009.1  94183638-94183733
            1960-2024           JAXUCZ010000009.1  94185672-94185736
            2025-2139           JAXUCZ010000009.1  94208242-94208356
            2140-2256           JAXUCZ010000009.1  94211676-94211792
            2257-2359           JAXUCZ010000009.1  94220604-94220706
            2360-2529           JAXUCZ010000009.1  94222213-94222382
            2530-2622           JAXUCZ010000009.1  94224700-94224792
            2623-2709           JAXUCZ010000009.1  94226345-94226431
            2710-2856           JAXUCZ010000009.1  94227291-94227437
            2857-3010           JAXUCZ010000009.1  94230687-94230840
            3011-3227           JAXUCZ010000009.1  94233002-94233218
FEATURES             Location/Qualifiers
     source          1..3227
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..3227
                     /gene="Psmd1"
                     /note="proteasome 26S subunit, non-ATPase 1"
                     /db_xref="GeneID:83806"
                     /db_xref="RGD:621669"
     exon            1..157
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..3003
                     /gene="Psmd1"
                     /note="26S proteasome p112 subunit; 26S proteasome
                     regulatory subunit S1; 26S proteasome regulatory subunit
                     RPN2; 26S proteasome, subunit p112; proteasome (prosome,
                     macropain) 26S subunit, non-ATPase, 1"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 1"
                     /protein_id="NP_114184.2"
                     /db_xref="GeneID:83806"
                     /db_xref="RGD:621669"
                     /translation="MITSAAGIISLLDEEEPQLKEFALHKLNAVVNDFWAEISESVDK
                     IEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIA
                     KCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRL
                     DVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQ
                     CLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIA
                     SVPGSTNTGTVPGPEKDSDSMETEEKTAGAVAGKTPDASPEPKDQTLKMIKILSGEMA
                     IELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEW
                     LARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIH
                     ANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVT
                     GEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADAL
                     IESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGF
                     ILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGVCCAGTGNKEAINLLEPMTNDPVNY
                     VRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAG
                     GHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMP
                     KVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEV
                     DEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLSMTETCRYQPFKPLSIGGIIIL
                     KDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD"
     exon            158..201
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..275
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..445
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..651
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..795
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1022
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1083
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1212
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1301
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1380
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1554
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1666
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1863
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1959
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2024
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2139
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2256
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2359
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2529
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2622
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2709
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2856
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..3010
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3227
                     /gene="Psmd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccggcggc ctgtgagggg actgactgag cagcgcaccc gggaacctgg aggtgcggta
       61 gagcaagcgg gccctgagct gacagatcca gggcttggcc agaactgtgg acgagcggat
      121 cggcgagtgc agggcgcagc catgatcact tcagccgctg gaattatttc tcttctggat
      181 gaagaagagc cacagctcaa ggaatttgca ctacacaaat tgaatgcagt tgtgaatgac
      241 ttctgggcag aaatttctga gtctgtagac aaaatagaag ttttatatga agatgaaggt
      301 ttccgcagtc ggcagtttgc agccttggtg gcatcgaaag tattttatca cctgggggct
      361 ttcgaggagt ctctgaatta tgctcttgga gcaggtgacc tcttcaatgt caatgataac
      421 tctgaatatg tggagactat tatagcaaaa tgcattgatc attataccaa acagtgtgtg
      481 gaaaatgcag atttgcctga aggagaaaag aagccaattg accagagatt ggaaggcatc
      541 gtgaataaga tgttccagcg atgtctcgat gatcacaagt ataagcaagc gattggcatt
      601 gctctggaga ccaggagact agatgtcttt gagaagacta tactggaatc taatgatgtc
      661 ccaggaatgc tagcttacag cctcaagctc tgcatgtctt taatgcagaa taagcagttt
      721 cggaataaag tattgcgagt cctggttaaa atctacatga acttggaaaa acctgatttc
      781 atcaatgttt gtcagtgctt aatcttctta gatgaccccc aggccgtgag tgatatctta
      841 gaaaagctgg taaaggaaga caacctgctg atggcctatc agatttgctt tgatttgtac
      901 gaaagtgcca gccagcagtt tttgtcatct gtgatccaga atcttcgaac tgttgggacc
      961 cctattgctt ctgtgcctgg atctaccaat acgggtactg tgccaggacc agagaaagac
     1021 agtgactcta tggagaccga ggagaagaca gccggtgcag tggcagggaa aacaccagac
     1081 gctagtccag agcccaagga ccagacattg aaaatgatta aaattttaag tggtgaaatg
     1141 gctatcgagt tacacctgca gttcctaata cgcaataata acacagacct catgattctg
     1201 aaaaacacaa aggatgcagt acgaaattct gtatgtcata cagcaactgt aatagcaaac
     1261 tcattcatgc actgtgggac taccagtgac cagttcctta gagataactt ggaatggctg
     1321 gccagagcca ctaactgggc caaatttact gcaactgcca gcttgggtgt aatccataag
     1381 ggccatgaga aggaagcact acagttaatg gcaacatacc tccctaagga cacttctcca
     1441 ggatcagcct atcaggaagg tggaggtctc tatgcattgg gtctcattca tgccaatcat
     1501 ggtggtgaca taattgacta tctccttaat cagctcaaga atgccagcaa tgatatcgtt
     1561 agacatggag gcagcttggg ccttggtttg gctgcaatgg gaactgcacg tcaggatgta
     1621 tatgatttgc tgaaaacaaa cctgtatcag gatgatgctg tgacagggga ggcagctggc
     1681 ctggccttag gtttggttat gttaggctct aaaaacgccc aggcgattga ggatatggtt
     1741 ggctatgcac aagaaactca acacgagaag attctgcgtg gtctagcagt tggcattgcg
     1801 ttagtgatgt atgggaggat ggaggaggcc gatgctctca ttgaatctct ctgtcgtgat
     1861 aaggacccaa ttcttagaag atctggaatg tatactgtag ccatggctta ttgtggctct
     1921 ggtaacaata aagctattcg acgcctgctg catgttgctg taagtgatgt caacgatgat
     1981 gtcagaagag cagcagtaga gtctcttggc ttcattttgt tcaggacgcc tgaacagtgt
     2041 ccaagtgtgg tctctttgtt gtccgagagt tataaccctc atgtgcgcta cggcgctgca
     2101 atggccctgg gagtctgctg tgctggtaca ggaaacaagg aagcaattaa tttactggag
     2161 ccaatgacca atgaccctgt gaactacgtg cggcaagggg ctctgatagc ctcagctctc
     2221 atcatgatcc aacagaccga aatcacgtgt ccaaaggtaa accagttccg gcagctgtat
     2281 tccaaagtca tcaatgacaa gcatgatgat gtcatggcca aatttggcgc tattctggcc
     2341 caaggcatac tggatgcagg tggtcataat gtcacaatct ccttacagtc caggactggg
     2401 cacactcata tgccttctgt ggttggcgtc cttgtcttta cccagttctg gttctggttt
     2461 cccctttcac acttcctatc attggcttat actcctacct gtgtcatcgg ccttaacaag
     2521 gatttaaaga tgccgaaagt tcaatataaa tcaaattgta aaccatccac attcgcatac
     2581 cctgcccctc tggaagttcc aaaagaaaaa gaaaaggaaa aggtttccac cgctgtgttg
     2641 tctattactg ccaaagctaa aaaaaaagaa aaagaaaaag aaaaaaagga ggaggagaag
     2701 atggaagtgg acgaagcaga aaagaaggaa gagaaagaga agaaaaaaga accggaacca
     2761 aacttccagc tgttggataa tccagcacgg gtcatgcctg cccagctgaa ggtcttaagt
     2821 atgacagaga cctgcagata ccaacccttc aagccactct ccatcggggg catcataatt
     2881 ctgaaagaca ccagcgaaga cattgaggaa cttgtggaac ccgtggcagc acatggccca
     2941 aagattgaag aggaggagca ggagccagag cccccagagc catttgagta catcgatgac
     3001 tagggccagg gatcccacct gctcagctgt agatgactat cctggcacac actgaaatgt
     3061 cgtgagggaa cccacgctga gacccgctcg atccacacat cattgcctac gctgacataa
     3121 ggaacccgtg tcctgagtct ttgattgaga agattctgac tgttcagtgt tctctttcac
     3181 aaaattggtt ttcaaataaa tatattaaaa tctccacatt gacaaga
//
