LOCUS       NM_031149               1288 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus proteasome 26S subunit, ATPase 5 (Psmc5), mRNA.
ACCESSION   NM_031149
VERSION     NM_031149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1288)
  AUTHORS   Farrell,K., Auerbach,A., Musaus,M., Navabpour,S., Liu,C., Lin,Y.,
            Xie,H. and Jarome,T.J.
  TITLE     Phosphorylation of RPT6 Controls Its Ability to Bind DNA and
            Regulate Gene Expression in the Hippocampus of Male Rats during
            Memory Formation
  JOURNAL   J Neurosci 44 (4), e1453232023 (2024)
   PUBMED   38124005
  REMARK    GeneRIF: Phosphorylation of RPT6 Controls Its Ability to Bind DNA
            and Regulate Gene Expression in the Hippocampus of Male Rats during
            Memory Formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1288)
  AUTHORS   Abu-El-Rub,E., Sareen,N., Lester Sequiera,G., Ammar,H.I., Yan,W.,
            ShamsEldeen,A.M., Rubinchik,I., Moudgil,M., Shokry,H.S.,
            Rashed,L.A. and Dhingra,S.
  TITLE     Hypoxia-induced increase in Sug1 leads to poor post-transplantation
            survival of allogeneic mesenchymal stem cells
  JOURNAL   FASEB J 34 (9), 12860-12876 (2020)
   PUBMED   32770803
  REMARK    GeneRIF: Hypoxia-induced increase in Sug1 leads to poor
            post-transplantation survival of allogeneic mesenchymal stem cells.
REFERENCE   3  (bases 1 to 1288)
  AUTHORS   Trask,S., Dulka,B.N. and Helmstetter,F.J.
  TITLE     Age-Related Memory Impairment Is Associated with Increased zif268
            Protein Accumulation and Decreased Rpt6 Phosphorylation
  JOURNAL   Int J Mol Sci 21 (15), 5352 (2020)
   PUBMED   32731408
  REMARK    GeneRIF: Age-Related Memory Impairment Is Associated with Increased
            zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1288)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   5  (bases 1 to 1288)
  AUTHORS   Djakovic,S.N., Marquez-Lona,E.M., Jakawich,S.K., Wright,R., Chu,C.,
            Sutton,M.A. and Patrick,G.N.
  TITLE     Phosphorylation of Rpt6 regulates synaptic strength in hippocampal
            neurons
  JOURNAL   J Neurosci 32 (15), 5126-5131 (2012)
   PUBMED   22496558
  REMARK    GeneRIF: CaMKII-dependent phosphorylation of Rpt6 at S120 may be an
            important regulatory mechanism for proteasome-dependent control of
            synaptic remodeling in slow homeostatic plasticity
REFERENCE   6  (bases 1 to 1288)
  AUTHORS   Makino,Y., Yogosawa,S., Kanemaki,M., Yoshida,T., Yamano,K.,
            Kishimoto,T., Moncollin,V., Egly,J.M., Muramatsu,M. and Tamura,T.
  TITLE     Structures of the rat proteasomal ATPases: determination of highly
            conserved structural motifs and rules for their spacing
  JOURNAL   Biochem Biophys Res Commun 220 (3), 1049-1054 (1996)
   PUBMED   8607789
REFERENCE   7  (bases 1 to 1288)
  AUTHORS   vom Baur,E., Zechel,C., Heery,D., Heine,M.J., Garnier,J.M.,
            Vivat,V., Le Douarin,B., Gronemeyer,H., Chambon,P. and Losson,R.
  TITLE     Differential ligand-dependent interactions between the AF-2
            activating domain of nuclear receptors and the putative
            transcriptional intermediary factors mSUG1 and TIF1
  JOURNAL   EMBO J 15 (1), 110-124 (1996)
   PUBMED   8598193
REFERENCE   8  (bases 1 to 1288)
  AUTHORS   Akiyama,K., Yokota,K., Kagawa,S., Shimbara,N., DeMartino,G.N.,
            Slaughter,C.A., Noda,C. and Tanaka,K.
  TITLE     cDNA cloning of a new putative ATPase subunit p45 of the human 26S
            proteasome, a homolog of yeast transcriptional factor Sug1p
  JOURNAL   FEBS Lett 363 (1-2), 151-156 (1995)
   PUBMED   7729537
REFERENCE   9  (bases 1 to 1288)
  AUTHORS   Lee,J.W., Ryan,F., Swaffield,J.C., Johnston,S.A. and Moore,D.D.
  TITLE     Interaction of thyroid-hormone receptor with a conserved
            transcriptional mediator
  JOURNAL   Nature 374 (6517), 91-94 (1995)
   PUBMED   7870181
REFERENCE   10 (bases 1 to 1288)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB000491.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000491.1, FQ213263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1288
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /note="proteasome 26S subunit, ATPase 5"
                     /db_xref="GeneID:81827"
                     /db_xref="RGD:708376"
     exon            1..39
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1236
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /note="proteasomal ATPase (SUG1); 26S protease regulatory
                     subunit 8; proteasome p45/SUG; TRIP1; proteasome subunit
                     p45; thyroid hormone receptor-interacting protein 1; 26S
                     proteasome AAA-ATPase subunit RPT6; for proteasomal ATPase
                     (SUG1); protease (prosome, macropain) 26S subunit, ATPase
                     5; peptidase (prosome, macropain) 26S subunit, ATPase 5;
                     proteasome (prosome, macropain) 26S subunit, ATPase, 5"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 8"
                     /protein_id="NP_112411.1"
                     /db_xref="GeneID:81827"
                     /db_xref="RGD:708376"
                     /translation="MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRR
                     LQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKN
                     IDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKE
                     IKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSE
                     LVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLEL
                     LNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSR
                     KMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQ
                     KDSEKNMSIKKLWK"
     exon            40..111
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            112..181
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..279
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..336
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..567
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..694
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..885
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..984
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1095
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1182
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1288
                     /gene="Psmc5"
                     /gene_synonym="Sug1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgaaagag ggaagatggc gcttgatggg ccagagcaga tggaactgga agaggggaag
       61 gcaggcagtg gactccgtca atattatctg tccaagattg aagaactcca gttgattgtg
      121 aatgacaaga gtcagaacct ccggagactg caggcccaga ggaatgagct caatgcaaaa
      181 gttcgtctgt tgcgggagga actgcagctg ctgcaggaac agggctccta cgttggagaa
      241 gtcgtgaggg ccatggataa gaaaaaagtg ttggtcaagg tccatcctga gggcaaattt
      301 gttgttgatg tggacaagaa cattgatatc aatgatgtga cacccaattg tcgggtggct
      361 ctaagaaatg acagctacac tctgcataag atcctgccta acaaagtgga ccctttggta
      421 tcactaatga tggtggaaaa ggtgccagac tcaacctacg agatgattgg cgggctagac
      481 aagcagatca aggagatcaa agaagtgatt gagctgcctg tgaagcaccc tgagctcttt
      541 gaagccctgg gcattgcaca gccaaaggga gtcctgctat atggaccccc gggcactggg
      601 aagacgttgt tggcccgggc tgtggctcat catacggact gtacctttat tcgtgtctct
      661 ggctctgaac tggtacagaa attcattggg gaaggggcaa gaatggtgag ggagctgttt
      721 gtcatggccc gagaacatgc tccctccatc atcttcatgg acgagatcga ctctatcggt
      781 tcttcacggc tggagggagg ctctggaggc gacagtgagg tacagcgcac aatgctggaa
      841 ctgctcaacc agctggatgg ctttgaggcc actaagaata tcaaggttat catggctact
      901 aataggattg atatcctgga ctctgccctg cttcgtcctg ggaggattga caggaaaatt
      961 gaattcccac ctcccaatga ggaggcccgg ctggacattt tgaaaatcca ctctcggaaa
     1021 atgaacttga ccagggggat caacctgagg aaaattgctg agttgatgcc aggagcttca
     1081 ggggctgaag tgaagggcgt gtgcacagag gccggcatgt atgctctgcg ggaacggcgt
     1141 gtccacgtta ctcaggagga ctttgagatg gcagtagcca aggtcatgca aaaggatagt
     1201 gagaaaaaca tgtccatcaa gaagctttgg aagtgagggt gtgtcctttg tgtggatccc
     1261 tcaaataaag gtctgtgcga taaactcc
//
