LOCUS       NM_057122               1412 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus proteasome 26S subunit, ATPase 4 (Psmc4), mRNA.
ACCESSION   NM_057122
VERSION     NM_057122.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1412)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 1412)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1412)
  AUTHORS   Rousseau,E., Kojima,R., Hoffner,G., Djian,P. and Bertolotti,A.
  TITLE     Misfolding of proteins with a polyglutamine expansion is
            facilitated by proteasomal chaperones
  JOURNAL   J Biol Chem 284 (3), 1917-1929 (2009)
   PUBMED   18986984
REFERENCE   4  (bases 1 to 1412)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   5  (bases 1 to 1412)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   6  (bases 1 to 1412)
  AUTHORS   Bingol,B. and Schuman,E.M.
  TITLE     Activity-dependent dynamics and sequestration of proteasomes in
            dendritic spines
  JOURNAL   Nature 441 (7097), 1144-1148 (2006)
   PUBMED   16810255
REFERENCE   7  (bases 1 to 1412)
  AUTHORS   Sakao,Y., Kawai,T., Takeuchi,O., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Takeda,K. and Akira,S.
  TITLE     Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and
            gene targeting
  JOURNAL   Genomics 67 (1), 1-7 (2000)
   PUBMED   10945464
REFERENCE   8  (bases 1 to 1412)
  AUTHORS   Makino,Y., Yogosawa,S., Kanemaki,M., Yoshida,T., Yamano,K.,
            Kishimoto,T., Moncollin,V., Egly,J.M., Muramatsu,M. and Tamura,T.
  TITLE     Structures of the rat proteasomal ATPases: determination of highly
            conserved structural motifs and rules for their spacing
  JOURNAL   Biochem Biophys Res Commun 220 (3), 1049-1054 (1996)
   PUBMED   8607789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 25, 2020 this sequence version replaced NM_057122.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225557.1, FQ226113.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000001.1  92484968-92485060   c
            94-192              JAXUCZ010000001.1  92484062-92484160   c
            193-379             JAXUCZ010000001.1  92483763-92483949   c
            380-526             JAXUCZ010000001.1  92482194-92482340   c
            527-636             JAXUCZ010000001.1  92482001-92482110   c
            637-730             JAXUCZ010000001.1  92481817-92481910   c
            731-898             JAXUCZ010000001.1  92477777-92477944   c
            899-975             JAXUCZ010000001.1  92477614-92477690   c
            976-1144            JAXUCZ010000001.1  92477304-92477472   c
            1145-1200           JAXUCZ010000001.1  92477065-92477120   c
            1201-1412           JAXUCZ010000001.1  92476690-92476901   c
FEATURES             Location/Qualifiers
     source          1..1412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1412
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /note="proteasome 26S subunit, ATPase 4"
                     /db_xref="GeneID:117262"
                     /db_xref="RGD:621102"
     exon            1..93
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1314
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /note="proteasome 26S ATPase subunit 4; 26S protease
                     regulatory subunit 6B; TBP-7; S6 ATPase; TAT-binding
                     protein 7; 26S proteasome AAA-ATPase subunit RPT3;
                     proteasome (prosome, macropain) 26S subunit, ATPase, 4"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 6B"
                     /protein_id="NP_476463.1"
                     /db_xref="GeneID:117262"
                     /db_xref="RGD:621102"
                     /translation="MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRY
                     KKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAI
                     VGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKP
                     DVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKA
                     VAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD
                     AQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFP
                     LPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRY
                     IVLAKDFEKAYKTVIKKDEQEHEFYK"
     exon            94..192
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            193..379
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            380..526
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            527..636
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            637..730
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            731..898
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            899..975
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1144
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1200
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1412
                     /gene="Psmc4"
                     /gene_synonym="Tbp7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggcgtca gcggaagccg tgactggccg ggctgcactg aggccggctt ggtcactatg
       61 gaggagatag gcattttggt ggagaaaatt caggatgaga tcccagcact gtccgtgtct
      121 cggccgcaga ccggcctgtc ctttctggga cccgaacctg aggacctgga ggacctatac
      181 agccgctaca agaagctaca gcaagagctg gagttcctgg aggtgcagga ggagtatatc
      241 aaggatgagc agaagaacct gaagaaggag ttcctccatg cgcaggagga ggtaaagcga
      301 atccagagca ttccgttggt cattggtcag tttttggaag ctgtggatca gaacacagcc
      361 attgtgggct ctaccacagg ctctaactac tatgtgcgca tcctgagtac cattgatcgg
      421 gagctgctca aacccaatgc ctcagtggcc ctgcacaagc acagcaacgc actggtggat
      481 gtgctgcctc ccgaggccga cagcagcatc atgatgctca cctcagacca gaagcccgac
      541 gtgatgtacg ccgatattgg aggcatggac atccagaagc aggaggtgcg ggaggctgtg
      601 gaactaccac tgacgcactt cgagctctac aagcagattg gcatcgatcc tccccgaggt
      661 gtcctcatgt atggcccacc tggctgtgga aagaccatgt tagcgaaggc tgtggcacat
      721 cacacgacag ctgcatttat ccgtgtggtg ggctcagagt ttgttcagaa gtacctgggt
      781 gagggccccc gaatggtccg ggatgtgttc cgcctggcca aggagaatgc acctgccatc
      841 atcttcatag atgaaattga tgccattgcc accaagagat tcgatgccca gacaggagct
      901 gacagggagg ttcagaggat cctgctggag ctactgaatc aaatggatgg atttgaccaa
      961 aacgtcaatg tgaaggtaat catggccaca aacagagcag acaccttgga tccagctcta
     1021 cttcggccag gacgcctgga ccgcaaaatt gaattcccac tccctgatcg tcgccagaag
     1081 aggttgattt tctccaccat caccagcaag atgaaccttt ctgaggaggt cgacctagaa
     1141 gactatgtgg cccgcccaga taagatttca ggagccgata tcaactccat ctgtcaggag
     1201 agtggaatgt tggctgtccg tgagaaccgc tacattgtcc tggccaagga cttcgagaaa
     1261 gcatacaaga ccgtgatcaa gaaagatgag caggaacatg agttttacaa gtgacccctc
     1321 cccacactcc ccaggcacct gtcccaaagg ctagttttct ctttacccag gattggtttc
     1381 gtcaataaat ggacgtgatt ggacctattt aa
//
