LOCUS       NM_033236               1462 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus proteasome 26S subunit, ATPase 2 (Psmc2), mRNA.
ACCESSION   NM_033236
VERSION     NM_033236.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Djakovic,S.N., Schwarz,L.A., Barylko,B., DeMartino,G.N. and
            Patrick,G.N.
  TITLE     Regulation of the proteasome by neuronal activity and
            calcium/calmodulin-dependent protein kinase II
  JOURNAL   J Biol Chem 284 (39), 26655-26665 (2009)
   PUBMED   19638347
  REMARK    GeneRIF: Data show that data provide a novel mechanism whereby
            CaMKII may regulate the proteasome in neurons to facilitate
            remodeling of synaptic connections through protein degradation.
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Yanagi,S., Shimbara,N. and Tamura,Ta.
  TITLE     Tissue and cell distribution of a mammalian proteasomal ATPase,
            MSS1, and its complex formation with the basal transcription
            factors
  JOURNAL   Biochem Biophys Res Commun 279 (2), 568-573 (2000)
   PUBMED   11118327
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Makino,Y., Yoshida,T., Yogosawa,S., Tanaka,K., Muramatsu,M. and
            Tamura,T.A.
  TITLE     Multiple mammalian proteasomal ATPases, but not proteasome itself,
            are associated with TATA-binding protein and a novel
            transcriptional activator, TIP120
  JOURNAL   Genes Cells 4 (9), 529-539 (1999)
   PUBMED   10526239
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Cai,H., Singh,I. and Wagner,B.J.
  TITLE     Gene expression of the proteasome in rat lens development
  JOURNAL   Exp Eye Res 66 (3), 339-346 (1998)
   PUBMED   9533861
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   Chen,Y., Sharp,Z.D. and Lee,W.H.
  TITLE     HEC binds to the seventh regulatory subunit of the 26 S proteasome
            and modulates the proteolysis of mitotic cyclins
  JOURNAL   J Biol Chem 272 (38), 24081-24087 (1997)
   PUBMED   9295362
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Makino,Y., Yogosawa,S., Kanemaki,M., Yoshida,T., Yamano,K.,
            Kishimoto,T., Moncollin,V., Egly,J.M., Muramatsu,M. and Tamura,T.
  TITLE     Structures of the rat proteasomal ATPases: determination of highly
            conserved structural motifs and rules for their spacing
  JOURNAL   Biochem Biophys Res Commun 220 (3), 1049-1054 (1996)
   PUBMED   8607789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 29, 2021 this sequence version replaced NM_033236.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ230973.1, FQ212821.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000004.1  14162245-14162390   c
            147-184             JAXUCZ010000004.1  14158880-14158917   c
            185-266             JAXUCZ010000004.1  14158186-14158267   c
            267-366             JAXUCZ010000004.1  14157407-14157506   c
            367-498             JAXUCZ010000004.1  14154179-14154310   c
            499-571             JAXUCZ010000004.1  14153754-14153826   c
            572-667             JAXUCZ010000004.1  14153137-14153232   c
            668-832             JAXUCZ010000004.1  14152447-14152611   c
            833-920             JAXUCZ010000004.1  14151390-14151477   c
            921-1123            JAXUCZ010000004.1  14148593-14148795   c
            1124-1220           JAXUCZ010000004.1  14148402-14148498   c
            1221-1462           JAXUCZ010000004.1  14148080-14148321   c
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1462
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /note="proteasome 26S subunit, ATPase 2"
                     /db_xref="GeneID:25581"
                     /db_xref="RGD:3428"
     exon            1..146
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1378
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /note="26S protease regulatory subunit 7; 26S proteasome
                     AAA-ATPase subunit RPT1; proteasome (prosome, macropain)
                     26S subunit, ATPase 2"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 7"
                     /protein_id="NP_150239.2"
                     /db_xref="GeneID:25581"
                     /db_xref="RGD:3428"
                     /translation="MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQ
                     IKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKII
                     NADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPT
                     VTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPP
                     GTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDE
                     IDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRP
                     GRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEA
                     GMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN"
     exon            147..184
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..266
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..366
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..498
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..571
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..667
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..832
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..920
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1123
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1220
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1462
                     /gene="Psmc2"
                     /gene_synonym="MSS1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagggaag acaccagcgg aagtggggaa cgtgctgtgt aatcactgag acgcggaggg
       61 gcttgcggct tctaaaatgc cggattacct aggtgcagac cagcggaaaa ccaaagagga
      121 tgagaaggac gacaagccca tccgagctct ggatgaaggg gatatcgcct tgttgaaaac
      181 ttatggccag agtacttatt cgaggcagat caagcaggtt gaagatgaca ttcagcaact
      241 tctcaaaaaa attaatgagc tcactggtat caaagagtcc gacactgggc tggcccctcc
      301 agccctctgg gatttggctg cagacaaaca gacacttcag agtgaacagc cgctacaggt
      361 tgcaagatgt accaagataa tcaacgccga ttcggaggac ccgaaataca tcatcaacgt
      421 gaagcagttt gccaagttcg tggtggatct cagtgatcag gtggcaccta ctgacattga
      481 ggaagggatg agagtcggcg tggacagaaa taaataccaa attcacattc cactgcctcc
      541 taagattgac ccaacagtta ccatgatgca ggtggaggaa aaacctgatg tcacatacag
      601 tgacgttggc ggctgtaagg aacagattga gaaattgcgg gaagtggttg aaacccctct
      661 actccatcca gagaggtttg ttaaccttgg aatcgagcct ccgaagggtg tgttgttatt
      721 tgggccacca ggcacaggca agaccctctg tgccagggca gtggccaatc ggactgatgc
      781 ttgcttcatc cgagttatcg ggtctgagct tgtacagaag tacgtcggtg agggggctcg
      841 aatggttcgg gagctttttg aaatggccag gacaaaaaaa gcctgcctta ttttctttga
      901 tgaaattgat gccattggag gggctcggtt tgacgatggc gctgggggtg acaatgaggt
      961 gcagaggacc atgttggagc tcatcaatca gctggatggc tttgatcctc ggggcaacat
     1021 caaagtgctc atggccacta accgacctga tactctggac ccagcgctga tgaggccagg
     1081 gaggctggac agaaagattg agttcagctt acctgactta gagggtcgaa cgcacatctt
     1141 taagattcat gctcgctcaa tgagtgtgga aagagacatc cgatttgagc tactagcccg
     1201 cctgtgtcca aacagtactg gagcggagat tagaagcgtt tgcacagagg ctggtatgtt
     1261 tgcaatccga gcccggagaa agattgctac agagaaggac ttcttagaag ctgtaaataa
     1321 ggtcatcaag tcgtatgcca aatttagtgc tactccccgc tacatgacat acaactgagc
     1381 cccagaggct ttgactgaag gaacttcctg tgcgttcata acttgttacc gcctcacaaa
     1441 aataaaagac ttaaaaactg tg
//
