LOCUS       NM_012708                913 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus proteasome 20S subunit beta 9 (Psmb9), mRNA.
ACCESSION   NM_012708
VERSION     NM_012708.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Chen,X., Mao,Y., Guo,Y., Xiao,D., Lin,Z., Huang,Y., Liu,Y.C.,
            Zhang,X. and Wang,Y.
  TITLE     LMP2 deficiency causes abnormal metabolism, oxidative stress,
            neuroinflammation, myelin loss and neurobehavioral dysfunctions
  JOURNAL   J Transl Med 21 (1), 226 (2023)
   PUBMED   36978132
  REMARK    GeneRIF: LMP2 deficiency causes abnormal metabolism, oxidative
            stress, neuroinflammation, myelin loss and neurobehavioral
            dysfunctions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Chen,X.Y., Wan,S.F., Yao,N.N., Lin,Z.J., Mao,Y.G., Yu,X.H. and
            Wang,Y.Z.
  TITLE     Inhibition of the immunoproteasome LMP2 ameliorates
            ischemia/hypoxia-induced blood-brain barrier injury through the
            Wnt/beta-catenin signalling pathway
  JOURNAL   Mil Med Res 8 (1), 62 (2021)
   PUBMED   34857032
  REMARK    GeneRIF: Inhibition of the immunoproteasome LMP2 ameliorates
            ischemia/hypoxia-induced blood-brain barrier injury through the
            Wnt/beta-catenin signalling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Brehm,A., Liu,Y., Sheikh,A., Marrero,B., Omoyinmi,E., Zhou,Q.,
            Montealegre,G., Biancotto,A., Reinhardt,A., Almeida de Jesus,A.,
            Pelletier,M., Tsai,W.L., Remmers,E.F., Kardava,L., Hill,S., Kim,H.,
            Lachmann,H.J., Megarbane,A., Chae,J.J., Brady,J., Castillo,R.D.,
            Brown,D., Casano,A.V., Gao,L., Chapelle,D., Huang,Y., Stone,D.,
            Chen,Y., Sotzny,F., Lee,C.C., Kastner,D.L., Torrelo,A.,
            Zlotogorski,A., Moir,S., Gadina,M., McCoy,P., Wesley,R.,
            Rother,K.I., Hildebrand,P.W., Brogan,P., Kruger,E.,
            Aksentijevich,I. and Goldbach-Mansky,R.
  TITLE     Additive loss-of-function proteasome subunit mutations in
            CANDLE/PRAAS patients promote type I IFN production
  JOURNAL   J Clin Invest 125 (11), 4196-4211 (2015)
   PUBMED   26524591
  REMARK    Erratum:[J Clin Invest. 2016 Feb;126(2):795. doi:
            10.1172/JCI86020.. Rother, Kristina [corrected to Rother, Kristina
            I]. PMID: 26829627]
REFERENCE   4  (bases 1 to 913)
  AUTHORS   Tuncel,J., Haag,S., Yau,A.C., Norin,U., Baud,A., Lonnblom,E.,
            Maratou,K., Ytterberg,A.J., Ekman,D., Thordardottir,S.,
            Johannesson,M., Gillett,A., Stridh,P., Jagodic,M., Olsson,T.,
            Fernandez-Teruel,A., Zubarev,R.A., Mott,R., Aitman,T.J., Flint,J.
            and Holmdahl,R.
  CONSRTM   EURATRANS Consortium
  TITLE     Natural polymorphisms in Tap2 influence negative selection and
            CD4ratioCD8 lineage commitment in the rat
  JOURNAL   PLoS Genet 10 (2), e1004151 (2014)
   PUBMED   24586191
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 913)
  AUTHORS   Karpova,Ia.D., Lyupina,Iu.V., Astakhova,T.M., Stepanova,A.A.,
            Erokhov,P.A., Abramova,E.B. and Sharova,N.P.
  TITLE     [Immune proteasomes in the development of rat immune system]
  JOURNAL   Bioorg Khim 39 (4), 400-410 (2013)
   PUBMED   24707720
REFERENCE   6  (bases 1 to 913)
  AUTHORS   Suzuki,K., Mori,A., Ishii,K.J., Saito,J., Singer,D.S.,
            Klinman,D.M., Krause,P.R. and Kohn,L.D.
  TITLE     Activation of target-tissue immune-recognition molecules by
            double-stranded polynucleotides
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2285-2290 (1999)
   PUBMED   10051633
REFERENCE   7  (bases 1 to 913)
  AUTHORS   Hohler,T., Schaper,T., Schneider,P.M., Krummenauer,F., Rittner,C.,
            Meyer zum Buschenfelde,K.H. and Marker-Hermann,E.
  TITLE     No primary association between LMP2 polymorphisms and extraspinal
            manifestations in spondyloarthropathies
  JOURNAL   Ann Rheum Dis 56 (12), 741-743 (1997)
   PUBMED   9496154
REFERENCE   8  (bases 1 to 913)
  AUTHORS   Proffitt,J.A. and Blair,G.E.
  TITLE     The MHC-encoded TAP1/LMP2 bidirectional promoter is down-regulated
            in highly oncogenic adenovirus type 12 transformed cells
  JOURNAL   FEBS Lett 400 (2), 141-144 (1997)
   PUBMED   9001385
REFERENCE   9  (bases 1 to 913)
  AUTHORS   Tamura,T., Shimbara,N., Aki,M., Ishida,N., Bey,F., Scherrer,K.,
            Tanaka,K. and Ichihara,A.
  TITLE     Molecular cloning of cDNAs for rat proteasomes: deduced primary
            structures of four other subunits
  JOURNAL   J Biochem 112 (4), 530-534 (1992)
   PUBMED   1491007
REFERENCE   10 (bases 1 to 913)
  AUTHORS   Lilley,K.S., Davison,M.D. and Rivett,A.J.
  TITLE     N-terminal sequence similarities between components of the
            multicatalytic proteinase complex
  JOURNAL   FEBS Lett 262 (2), 327-329 (1990)
   PUBMED   2335214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP500440.1, BC091161.1 and D10757.1.
            
            On Sep 17, 2009 this sequence version replaced NM_012708.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP500440.1, BC091161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BP500440.1         6-17
            13-903              BC091161.1         1-891
            904-913             D10757.1           871-880
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..913
                     /gene="Psmb9"
                     /gene_synonym="Lmp2"
                     /note="proteasome 20S subunit beta 9"
                     /db_xref="GeneID:24967"
                     /db_xref="RGD:3427"
     exon            1..111
                     /gene="Psmb9"
                     /gene_synonym="Lmp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..711
                     /gene="Psmb9"
                     /gene_synonym="Lmp2"
                     /EC_number="3.4.25.1"
                     /note="large multifunctional protease 2; low molecular
                     mass polypeptide 2; RING12 protein; macropain chain 7;
                     proteasome subunit beta 9; proteasome chain 7; proteasome
                     subunit beta-1i; low molecular mass protein 2;
                     multicatalytic endopeptidase complex chain 7; really
                     interesting new gene 12 protein; proteosome (prosome,
                     macropain) subunit, beta type 9; proteasome (prosome,
                     macropain) subunit, beta type 9 (large multifunctional
                     peptidase 2); proteasome (prosome, macropain) subunit,
                     beta type, 9"
                     /codon_start=1
                     /product="proteasome subunit beta type-9"
                     /protein_id="NP_036840.2"
                     /db_xref="GeneID:24967"
                     /db_xref="RGD:3427"
                     /translation="MLQAGAPTAGSFRTGEVHTGTTIMAVEFDGGVVVGSDSRVSAGA
                     AVVNRVFDKLSPLHQRIYCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANI
                     VKNISYKYREDLLAHLMVAGWDQREGGQVYGTMGGMLIRQPFAIGGSGSTYIYGYVDA
                     AYKPGMTPEECRRFTTDAITLAMNRDGSSGGVIYLVTITADGVDHRVILGDELPKFYD
                     E"
     exon            112..179
                     /gene="Psmb9"
                     /gene_synonym="Lmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            180..311
                     /gene="Psmb9"
                     /gene_synonym="Lmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..441
                     /gene="Psmb9"
                     /gene_synonym="Lmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..583
                     /gene="Psmb9"
                     /gene_synonym="Lmp2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..913
                     /gene="Psmb9"
                     /gene_synonym="Lmp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttcgccgc acgccgctgc tgattggaaa ccagagctcc gcactgctag gatgctgcaa
       61 gccggagcac ctaccgccgg ctctttccgg acgggagaag tccacaccgg gacaaccatc
      121 atggctgtgg aatttgacgg gggtgtcgtg gtgggctctg attcccgagt gtcagcggga
      181 gcagccgtag tgaaccgcgt gtttgacaag ctctcccctc tgcaccagcg catctactgt
      241 gccctctcgg gttccgctgc tgatgcccaa gccatagcgg acatggccgc ctaccagctg
      301 gagctgcacg ggttggaact ggaggagccg ccccttgttc tggctgctgc aaacatagtg
      361 aagaacatct cctacaagta ccgcgaggac ttgttagcgc atctcatggt agctggttgg
      421 gaccaacgtg aggggggcca ggtgtatgga accatgggag ggatgctaat tcgacagccc
      481 tttgcaatcg gtggttccgg aagcacctat atttacggtt atgtggacgc agcttataaa
      541 ccaggcatga cccccgagga gtgccggcgt ttcaccacag acgccatcac tctggccatg
      601 aaccgagatg gctccagtgg gggtgtcatc tacctggtca ccattacagc tgatggtgtg
      661 gaccatcgcg tcatcctggg agacgagctg ccaaaattct acgatgagtg aagtcccttc
      721 tttgtttgca ataaacttta tggagccaga ggttggtgta atgggcagag gtgaaatggg
      781 tatcagagaa acgcagtgcg tggagggaag cttcctcccg gcccagagat cagcaagcac
      841 ctcccattct tttttaaaaa ataaacttta ttattaaaat aaaaaactct tataaataaa
      901 aaataagtaa aac
//
