LOCUS       NM_053532                993 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus proteasome 20S subunit beta 7 (Psmb7), mRNA.
ACCESSION   NM_053532
VERSION     NM_053532.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 993)
  AUTHORS   Kyrychenko,V.O., Nagibin,V.S., Tumanovska,L.V., Pashevin,D.O.,
            Gurianova,V.L., Moibenko,A.A., Dosenko,V.E. and Klionsky,D.J.
  TITLE     Knockdown of PSMB7 induces autophagy in cardiomyocyte cultures:
            possible role in endoplasmic reticulum stress
  JOURNAL   Pathobiology 81 (1), 8-14 (2014)
   PUBMED   23969338
  REMARK    GeneRIF: Our results indicate that Psmb7 knockdown induces
            endoplasmic reticulum stress and autophagy in cardiomyocytes
REFERENCE   2  (bases 1 to 993)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 993)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 993)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   5  (bases 1 to 993)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   6  (bases 1 to 993)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 993)
  AUTHORS   Hayashi,M., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     The mouse genes encoding the third pair of beta-type proteasome
            subunits regulated reciprocally by IFN-gamma: structural
            comparison, chromosomal localization, and analysis of the promoter
  JOURNAL   J Immunol 159 (6), 2760-2770 (1997)
   PUBMED   9300697
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF285103.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF285103.1, BC060551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..993
                     /gene="Psmb7"
                     /note="proteasome 20S subunit beta 7"
                     /db_xref="GeneID:85492"
                     /db_xref="RGD:621093"
     exon            1..69
                     /gene="Psmb7"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..841
                     /gene="Psmb7"
                     /EC_number="3.4.25.1"
                     /note="macropain chain Z; beta-2; proteasome subunit Z;
                     multicatalytic endopeptidase complex chain Z; proteasome
                     beta 7 subunit; proteasome (prosome, macropain) subunit,
                     beta type 7; proteasome subunit beta 7; proteasome subunit
                     beta-2"
                     /codon_start=1
                     /product="proteasome subunit beta type-7"
                     /protein_id="NP_445984.1"
                     /db_xref="GeneID:85492"
                     /db_xref="RGD:621093"
                     /translation="MAAVSVFQAPVGGFSFDNCRRNAVLEADFAKKGFKLPKARKTGT
                     TIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI
                     SSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHG
                     STDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDL
                     CVISKSKLDFLRPYSVPNKKGTRFGRYRCEKGTTAVLTEKVTPLELEVLEEIVQTMDT
                     S"
     exon            70..163
                     /gene="Psmb7"
                     /inference="alignment:Splign:2.1.0"
     exon            164..261
                     /gene="Psmb7"
                     /inference="alignment:Splign:2.1.0"
     exon            262..402
                     /gene="Psmb7"
                     /inference="alignment:Splign:2.1.0"
     exon            403..518
                     /gene="Psmb7"
                     /inference="alignment:Splign:2.1.0"
     exon            519..577
                     /gene="Psmb7"
                     /inference="alignment:Splign:2.1.0"
     exon            578..729
                     /gene="Psmb7"
                     /inference="alignment:Splign:2.1.0"
     exon            730..972
                     /gene="Psmb7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggaagatg gcggctgtgt cggtgtttca ggcaccggtc ggaggctttt cttttgataa
       61 ttgccgcagg aatgcggtct tggaagctga ttttgcaaaa aaggggttca aacttccgaa
      121 agctcggaaa actggcacta ccatcgcggg ggtggtctat aaggatggaa tagttcttgg
      181 agcagacacg agagcaactg aagggatggt tgttgctgac aaaaactgtt caaaaattca
      241 cttcatatct cctaatattt attgctgtgg tgctgggaca gctgcagaca cagacatgac
      301 aacccagctt atttcttcta acttggagct ccactctctc accaccggcc gccttcccag
      361 agttgtcaca gcgaatcgga tgctgaagca gatgcttttc aggtatcaag gttacattgg
      421 tgcagcccta gttttggggg gagtcgatgt tactggacct catctctaca gcatctatcc
      481 gcatggatca actgataaac tgccttatgt caccatgggt tctggctcct tggcagcaat
      541 ggctgtgttt gaagataagt ttaggccaga tatggaggag gaagaagcca agaagctagt
      601 gagtgaagct attgcagctg gcatctttaa tgacttgggg tctggaagca acattgatct
      661 gtgtgttatc agcaagagca agctggactt tctccgtcca tactcagtgc ccaacaagaa
      721 agggaccagg tttggccggt acaggtgtga gaaaggcact accgctgtcc tcacggagaa
      781 agtcacccct ctggagctcg aggtgctaga agagattgtt cagacaatgg acacttcgtg
      841 aatggtgctg cgggcagttg gatagctctc tgggtgactc ggtgtacatg ccacccctgc
      901 cccaccccac tctaccccaa tcagaaaaca tgcatttggc tattgctcaa ttaaaacaaa
      961 ccagaaaact taaaaaaaaa aaaaaaaaaa aaa
//
