LOCUS       NP_445984                277 aa            linear   ROD 20-OCT-2024
DEFINITION  proteasome subunit beta type-7 [Rattus norvegicus].
ACCESSION   NP_445984
VERSION     NP_445984.1
DBSOURCE    REFSEQ: accession NM_053532.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 277)
  AUTHORS   Kyrychenko,V.O., Nagibin,V.S., Tumanovska,L.V., Pashevin,D.O.,
            Gurianova,V.L., Moibenko,A.A., Dosenko,V.E. and Klionsky,D.J.
  TITLE     Knockdown of PSMB7 induces autophagy in cardiomyocyte cultures:
            possible role in endoplasmic reticulum stress
  JOURNAL   Pathobiology 81 (1), 8-14 (2014)
   PUBMED   23969338
  REMARK    GeneRIF: Our results indicate that Psmb7 knockdown induces
            endoplasmic reticulum stress and autophagy in cardiomyocytes
REFERENCE   2  (residues 1 to 277)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (residues 1 to 277)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (residues 1 to 277)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   5  (residues 1 to 277)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   6  (residues 1 to 277)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (residues 1 to 277)
  AUTHORS   Hayashi,M., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     The mouse genes encoding the third pair of beta-type proteasome
            subunits regulated reciprocally by IFN-gamma: structural
            comparison, chromosomal localization, and analysis of the promoter
  JOURNAL   J Immunol 159 (6), 2760-2770 (1997)
   PUBMED   9300697
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF285103.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF285103.1, BC060551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     Protein         1..277
                     /product="proteasome subunit beta type-7"
                     /EC_number="3.4.25.1"
                     /note="macropain chain Z; beta-2; proteasome subunit Z;
                     multicatalytic endopeptidase complex chain Z; proteasome
                     beta 7 subunit; proteasome (prosome, macropain) subunit,
                     beta type 7; proteasome subunit beta 7; proteasome subunit
                     beta-2"
                     /calculated_mol_wt=29796
     mat_peptide     44..277
                     /product="Proteasome subunit beta type-7.
                     /id=PRO_0000026650"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHW0.1)"
                     /calculated_mol_wt=25314
     Region          44..232
                     /region_name="proteasome_beta_type_7"
                     /note="proteasome beta type-7 subunit. The 20S proteasome,
                     multisubunit proteolytic complex, is the central enzyme of
                     nonlysosomal protein degradation in both the cytosol and
                     nucleus. It is composed of 28 subunits arranged as four
                     homoheptameric rings that...; cd03763"
                     /db_xref="CDD:239732"
     Site            order(44,60,62,76,172,209,212..213)
                     /site_type="active"
                     /db_xref="CDD:239732"
     Site            order(62,65,67..72,92,94,109,121,124..125,127..128,131,
                     134,157,159,161..164,167,175..176,178..179,182..184,200,
                     207..210,213..214)
                     /site_type="other"
                     /note="beta subunit interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239732"
     Region          235..271
                     /region_name="Pr_beta_C"
                     /note="Proteasome beta subunits C terminal; pfam12465"
                     /db_xref="CDD:463597"
     CDS             1..277
                     /gene="Psmb7"
                     /coded_by="NM_053532.1:8..841"
                     /db_xref="GeneID:85492"
                     /db_xref="RGD:621093"
ORIGIN      
        1 maavsvfqap vggfsfdncr rnavleadfa kkgfklpkar ktgttiagvv ykdgivlgad
       61 trategmvva dkncskihfi spniyccgag taadtdmttq lissnlelhs lttgrlprvv
      121 tanrmlkqml fryqgyigaa lvlggvdvtg phlysiyphg stdklpyvtm gsgslaamav
      181 fedkfrpdme eeeakklvse aiaagifndl gsgsnidlcv iskskldflr pysvpnkkgt
      241 rfgryrcekg ttavltekvt plelevleei vqtmdts
//
