LOCUS       NM_057099                796 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus proteasome 20S subunit beta 6 (Psmb6), mRNA.
ACCESSION   NM_057099
VERSION     NM_057099.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 796)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 796)
  AUTHORS   Wang,J., Xu,L., Yun,X., Yang,K., Liao,D., Tian,L., Jiang,H. and
            Lu,W.
  TITLE     Proteomic analysis reveals that proteasome subunit beta 6 is
            involved in hypoxia-induced pulmonary vascular remodeling in rats
  JOURNAL   PLoS One 8 (7), e67942 (2013)
   PUBMED   23844134
  REMARK    GeneRIF: the present study revealed for the first time that one of
            the proteasome subunits, PSMB6, was increased in the distal PA from
            a CHPH rat model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 796)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 796)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 796)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   6  (bases 1 to 796)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   7  (bases 1 to 796)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   8  (bases 1 to 796)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   9  (bases 1 to 796)
  AUTHORS   Tamura,T., Shimbara,N., Aki,M., Ishida,N., Bey,F., Scherrer,K.,
            Tanaka,K. and Ichihara,A.
  TITLE     Molecular cloning of cDNAs for rat proteasomes: deduced primary
            structures of four other subunits
  JOURNAL   J Biochem 112 (4), 530-534 (1992)
   PUBMED   1491007
REFERENCE   10 (bases 1 to 796)
  AUTHORS   Lilley,K.S., Davison,M.D. and Rivett,A.J.
  TITLE     N-terminal sequence similarities between components of the
            multicatalytic proteinase complex
  JOURNAL   FEBS Lett 262 (2), 327-329 (1990)
   PUBMED   2335214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 19, 2021 this sequence version replaced NM_057099.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217385.1, CN542776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000010.1  55737888-55738012
            126-193             JAXUCZ010000010.1  55738402-55738469
            194-325             JAXUCZ010000010.1  55738811-55738942
            326-455             JAXUCZ010000010.1  55739063-55739192
            456-600             JAXUCZ010000010.1  55739765-55739909
            601-796             JAXUCZ010000010.1  55740023-55740218
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..796
                     /gene="Psmb6"
                     /gene_synonym="Psmb6l"
                     /note="proteasome 20S subunit beta 6"
                     /db_xref="GeneID:29666"
                     /db_xref="RGD:61881"
     exon            1..125
                     /gene="Psmb6"
                     /gene_synonym="Psmb6l"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..743
                     /gene="Psmb6"
                     /gene_synonym="Psmb6l"
                     /EC_number="3.4.25.1"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     6; proteasome beta 6 subunit; proteasome chain 5;
                     proteasome subunit Y; macropain delta chain; proteasome
                     delta chain; multicatalytic endopeptidase complex delta
                     chain; proteasome subunit beta 6; beta-1; proteasome
                     subunit beta-1"
                     /codon_start=1
                     /product="proteasome subunit beta type-6"
                     /protein_id="NP_476440.2"
                     /db_xref="GeneID:29666"
                     /db_xref="RGD:61881"
                     /translation="MAAALAVRGAVSAPAFGPEALTPDWENREVSTGTTIMAVQFDGG
                     VVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIE
                     LNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAI
                     GGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQQSGVE
                     RQVLLGDQIPKVTISTLPPP"
     exon            126..193
                     /gene="Psmb6"
                     /gene_synonym="Psmb6l"
                     /inference="alignment:Splign:2.1.0"
     exon            194..325
                     /gene="Psmb6"
                     /gene_synonym="Psmb6l"
                     /inference="alignment:Splign:2.1.0"
     exon            326..455
                     /gene="Psmb6"
                     /gene_synonym="Psmb6l"
                     /inference="alignment:Splign:2.1.0"
     exon            456..600
                     /gene="Psmb6"
                     /gene_synonym="Psmb6l"
                     /inference="alignment:Splign:2.1.0"
     exon            601..796
                     /gene="Psmb6"
                     /gene_synonym="Psmb6l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttgtggca gctgtagaag aggaagatgg cggccgcctt agctgttcgt ggagccgtct
       61 ctgcaccggc ctttgggccg gaggcgctca ctccagactg ggaaaaccga gaagtctcca
      121 cagggaccac gatcatggct gtgcaatttg acgggggcgt ggttctagga gcagactcca
      181 gaacaaccac tgggtcgtac atcgccaatc gagtgactga caagctgacc cctatccacg
      241 atcacatctt ctgctgccgc tcaggctcgg cagctgatac ccaagcagta gctgatgctg
      301 tcacgtacca gcttggtttc cacagtattg agctgaacga gcctccacta gtgcacacag
      361 ccgccagtct ctttaaggag atgtgttacc gctacagaga agatctgatg gcaggaatca
      421 tcatcgcagg ctgggaccct caagaaggag ggcaggtgta ctctgttccc atgggaggta
      481 tgatggtaag acagtccttt gccatcggag gctccgggag ctcatatatc tatggctatg
      541 ttgatgctac ctatcgggaa ggcatgacca aggatgaatg tctgcaattc actgccaatg
      601 ctcttgcttt ggctatggaa cgggatggct ccagtggagg agtgatccgc ttggcagcca
      661 ttcaacagtc gggggtagag cggcaggtgc ttttgggaga ccagatcccc aaggtcacca
      721 tctccacttt gccacctccc tgaagcctag gattcccatc ccgacgcaca agctaataaa
      781 cagattgtca aagacc
//
