LOCUS       NM_031629                943 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus proteasome 20S subunit beta 4 (Psmb4), mRNA.
ACCESSION   NM_031629
VERSION     NM_031629.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 943)
  AUTHORS   Yang,C., Yu,P., Yang,F., He,Q., Jiang,B., Zheng,L., Wang,Q.,
            Wang,J., Qiu,H., Wang,H. and Zhang,L.
  TITLE     PSMB4 inhibits cardiomyocyte apoptosis via activating NF-kappaB
            signaling pathway during myocardial ischemia/reperfusion injury
  JOURNAL   J Mol Histol 52 (4), 693-703 (2021)
   PUBMED   33954843
  REMARK    GeneRIF: PSMB4 inhibits cardiomyocyte apoptosis via activating
            NF-kappaB signaling pathway during myocardial ischemia/reperfusion
            injury.
REFERENCE   2  (bases 1 to 943)
  AUTHORS   Wu,C., Chen,J., Liu,Y., Zhang,J., Ding,W., Wang,S., Bao,G., Xu,G.,
            Sun,Y., Wang,L., Chen,L., Gu,H., Cui,B. and Cui,Z.
  TITLE     Upregulation of PSMB4 is Associated with the Necroptosis after
            Spinal Cord Injury
  JOURNAL   Neurochem Res 41 (11), 3103-3112 (2016)
   PUBMED   27514644
  REMARK    GeneRIF: that PSMB4 is associated with RIP3 involved necroptosis
            after Spinal cord injury
REFERENCE   3  (bases 1 to 943)
  AUTHORS   Brehm,A., Liu,Y., Sheikh,A., Marrero,B., Omoyinmi,E., Zhou,Q.,
            Montealegre,G., Biancotto,A., Reinhardt,A., Almeida de Jesus,A.,
            Pelletier,M., Tsai,W.L., Remmers,E.F., Kardava,L., Hill,S., Kim,H.,
            Lachmann,H.J., Megarbane,A., Chae,J.J., Brady,J., Castillo,R.D.,
            Brown,D., Casano,A.V., Gao,L., Chapelle,D., Huang,Y., Stone,D.,
            Chen,Y., Sotzny,F., Lee,C.C., Kastner,D.L., Torrelo,A.,
            Zlotogorski,A., Moir,S., Gadina,M., McCoy,P., Wesley,R.,
            Rother,K.I., Hildebrand,P.W., Brogan,P., Kruger,E.,
            Aksentijevich,I. and Goldbach-Mansky,R.
  TITLE     Additive loss-of-function proteasome subunit mutations in
            CANDLE/PRAAS patients promote type I IFN production
  JOURNAL   J Clin Invest 125 (11), 4196-4211 (2015)
   PUBMED   26524591
  REMARK    Erratum:[J Clin Invest. 2016 Feb;126(2):795. doi:
            10.1172/JCI86020.. Rother, Kristina [corrected to Rother, Kristina
            I]. PMID: 26829627]
REFERENCE   4  (bases 1 to 943)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 943)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   6  (bases 1 to 943)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 943)
  AUTHORS   Qureshi,N., Perera,P.Y., Shen,J., Zhang,G., Lenschat,A.,
            Splitter,G., Morrison,D.C. and Vogel,S.N.
  TITLE     The proteasome as a lipopolysaccharide-binding protein in
            macrophages: differential effects of proteasome inhibition on
            lipopolysaccharide-induced signaling events
  JOURNAL   J Immunol 171 (3), 1515-1525 (2003)
   PUBMED   12874245
REFERENCE   8  (bases 1 to 943)
  AUTHORS   Thomson,S. and Rivett,A.J.
  TITLE     Processing of N3, a mammalian proteasome beta-type subunit
  JOURNAL   Biochem J 315 (Pt 3) (Pt 3), 733-738 (1996)
   PUBMED   8645151
REFERENCE   9  (bases 1 to 943)
  AUTHORS   Thomson,S., Balson,D.F. and Rivett,A.J.
  TITLE     cDNA cloning of a new type of subunit of mammalian proteasomes
  JOURNAL   FEBS Lett 322 (2), 135-138 (1993)
   PUBMED   8482379
REFERENCE   10 (bases 1 to 943)
  AUTHORS   Lilley,K.S., Davison,M.D. and Rivett,A.J.
  TITLE     N-terminal sequence similarities between components of the
            multicatalytic proteinase complex
  JOURNAL   FEBS Lett 262 (2), 327-329 (1990)
   PUBMED   2335214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ232850.1.
            
            On May 5, 2015 this sequence version replaced NM_031629.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227250.1, FQ232850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..943
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..943
                     /gene="Psmb4"
                     /note="proteasome 20S subunit beta 4"
                     /db_xref="GeneID:58854"
                     /db_xref="RGD:61877"
     exon            1..165
                     /gene="Psmb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..820
                     /gene="Psmb4"
                     /EC_number="3.4.25.1"
                     /note="RN3; proteasome chain 3; macropain beta chain;
                     proteasome beta chain; multicatalytic endopeptidase
                     complex beta chain; proteasome beta 4 subunit; proteasome
                     (prosome, macropain) subunit, beta type 4; proteasome
                     subunit beta 4; beta-7; proteasome subunit beta-7"
                     /codon_start=1
                     /product="proteasome subunit beta type-4"
                     /protein_id="NP_113817.2"
                     /db_xref="GeneID:58854"
                     /db_xref="RGD:61877"
                     /translation="MEAFWESRTGHWAGGPAPGQFYRVPSTPSCLMDPMSAPCEGPIT
                     RTQNPMVTGTSVLGVKFDCGVVIAADMLGSYGSLARFRNISRIMRVNDSTMLGASGDY
                     ADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGY
                     AGGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARELVERCM
                     RVLYYRDARSYNRFQVATVTEKGVEIEGPLSAQTNWDIAHMISGFE"
     exon            166..372
                     /gene="Psmb4"
                     /inference="alignment:Splign:2.1.0"
     exon            373..519
                     /gene="Psmb4"
                     /inference="alignment:Splign:2.1.0"
     exon            520..601
                     /gene="Psmb4"
                     /inference="alignment:Splign:2.1.0"
     exon            602..718
                     /gene="Psmb4"
                     /inference="alignment:Splign:2.1.0"
     exon            719..807
                     /gene="Psmb4"
                     /inference="alignment:Splign:2.1.0"
     exon            808..923
                     /gene="Psmb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cattttttcg gcagtggtga ctaagatgga agcgttttgg gagtcacgga ctggccactg
       61 ggccgggggt ccggctccgg ggcagtttta ccgcgtcccg tccaccccca gctgcctcat
      121 ggatccgatg tctgcgccct gcgagggtcc catcactcgg acccagaacc ccatggtgac
      181 tgggacatcc gtactagggg tgaagttcga ctgcggagtg gtgattgctg cagacatgct
      241 gggctcctac ggctccctgg ctcgtttccg caatatctct cgtattatgc gagtcaacga
      301 cagcactatg ctaggtgctt caggagacta tgctgatttc cagtatttga agcaagttct
      361 cggccagatg gtgattgatg aggagctgtt gggagatgga catagctata gtcctagagc
      421 tatccattca tggttgacaa gggccatgta cagtcgccgc tccaagatga accctctgtg
      481 gaacaccatg gtcattggag gctatgctgg tggagaaagc tttcttggtt atgtggacat
      541 gcttggtgta gcttatgaag ccccttcact agccactggt tatggtgcat acttggctca
      601 gcctctgctt cgagaagttc tagagaagca accggtgctg agtcagacag aggcccgaga
      661 gcttgtggag cgctgcatgc gagtgctgta ctaccgagac gctcgttcgt ataaccggtt
      721 tcaagttgct actgtaactg aaaaaggtgt ggagatagaa ggaccactgt cagcacagac
      781 caactgggac attgctcaca tgatcagtgg ctttgaatga aatccagatg aagtgtccag
      841 agttgaagct tggcccttgt gaacgtgact gtagctggct caaaggcaga cttttgtaaa
      901 aataaatcag tcctttgaag tgtaaaaaaa aaaaaaaaaa aaa
//
