LOCUS       NM_017285                824 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus proteasome 20S subunit beta 3 (Psmb3), mRNA.
ACCESSION   NM_017285
VERSION     NM_017285.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 824)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 824)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 824)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 824)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 824)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   6  (bases 1 to 824)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 824)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
REFERENCE   8  (bases 1 to 824)
  AUTHORS   Nishimura,C., Tamura,T., Akioka,H., Tokunaga,F., Tanaka,K. and
            Ichihara,A.
  TITLE     cDNA cloning of rat proteasome subunit RC10-II, assumed to be
            responsible for trypsin-like catalytic activity
  JOURNAL   FEBS Lett 336 (3), 462-466 (1993)
   PUBMED   8282111
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 13, 2018 this sequence version replaced NM_017285.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ232780.1, FQ211229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000010.1  83193787-83193862
            77-261              JAXUCZ010000010.1  83194159-83194343
            262-369             JAXUCZ010000010.1  83197831-83197938
            370-547             JAXUCZ010000010.1  83198254-83198431
            548-642             JAXUCZ010000010.1  83199735-83199829
            643-824             JAXUCZ010000010.1  83200702-83200883
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..824
                     /gene="Psmb3"
                     /note="proteasome 20S subunit beta 3"
                     /db_xref="GeneID:29676"
                     /db_xref="RGD:61875"
     exon            1..76
                     /gene="Psmb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..691
                     /gene="Psmb3"
                     /EC_number="3.4.25.1"
                     /note="proteasome chain 13; proteasome theta chain;
                     proteasome component C10-II; proteasome beta 3 subunit;
                     proteasome (prosome, macropain) subunit, beta type 3;
                     proteasome subunit beta 3; beta-3"
                     /codon_start=1
                     /product="proteasome subunit beta type-3"
                     /protein_id="NP_058981.1"
                     /db_xref="GeneID:29676"
                     /db_xref="RGD:61875"
                     /translation="MSVMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFP
                     MGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGP
                     YYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDP
                     EHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD"
     exon            77..261
                     /gene="Psmb3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..369
                     /gene="Psmb3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..547
                     /gene="Psmb3"
                     /inference="alignment:Splign:2.1.0"
     exon            548..642
                     /gene="Psmb3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..824
                     /gene="Psmb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgttggccct gagaaagcca gaaccggttt gtaggcagcg cagtggagat cgggttccta
       61 ttacagtgca atcatgtctg ttatgtccta taatggaggg gccgtcatgg ccatgaaggg
      121 aaagaactgt gtggccatcg ctgcagacag gcgtttcgga atccaggccc aaatggtgac
      181 cacggacttc cagaagatct ttcccatggg tgacaggctc tacataggcc tggccggcct
      241 ggccactgac gtccagacag ttgcccagcg tctcaagttc cgactgaacc tgtacgagct
      301 gaaggaagga cggcagatca agccttacac cctgatgagc atggtggcca acctcttgta
      361 tgagaaacgg tttggtccct actacacaga acctgtcatt gctggcttgg acccgaagac
      421 ctttaagccc ttcatttgct ctctggacct cattggctgt cccatggtga cagatgactt
      481 cgtagtcagt ggcacctgct ctgaacaaat gtatgggatg tgtgagtctc tctgggagcc
      541 caacatggat ccagagcacc tgtttgagac catttctcag gccatgctga atgctgtgga
      601 cagggatgcc gtgtcgggca tgggcgtcat tgtccacatc attgaaaaag acaagatcac
      661 caccaggaca ctgaaggcgc ggatggacta acctgtgctc tggccccgtc tcccttttgt
      721 tgtttttctt tttaataaaa tctcctttct ttcatgcctg cccgcccttg tttctgcgac
      781 tttgtcccca tcagggagag cccaatacag agcgacttta tctc
//
