LOCUS       NM_017284                792 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus proteasome 20S subunit beta 2 (Psmb2), mRNA.
ACCESSION   NM_017284
VERSION     NM_017284.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 792)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 792)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 792)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 792)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 792)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 792)
  AUTHORS   Wang,X., Chen,C.F., Baker,P.R., Chen,P.L., Kaiser,P. and Huang,L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   7  (bases 1 to 792)
  AUTHORS   Tengowski,M.W., Feng,D., Sutovsky,M. and Sutovsky,P.
  TITLE     Differential expression of genes encoding constitutive and
            inducible 20S proteasomal core subunits in the testis and
            epididymis of theophylline- or 1,3-dinitrobenzene-exposed rats
  JOURNAL   Biol Reprod 76 (1), 149-163 (2007)
   PUBMED   16988215
REFERENCE   8  (bases 1 to 792)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   9  (bases 1 to 792)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
REFERENCE   10 (bases 1 to 792)
  AUTHORS   Nishimura,C., Tamura,T., Tokunaga,F., Tanaka,K. and Ichihara,A.
  TITLE     cDNA cloning of rat proteasome subunit RC7-I, a homologue of yeast
            PRE1 essential for chymotrypsin-like activity
  JOURNAL   FEBS Lett 332 (1-2), 52-56 (1993)
   PUBMED   8405448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D21799.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058487.1, FQ217737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..792
                     /gene="Psmb2"
                     /note="proteasome 20S subunit beta 2"
                     /db_xref="GeneID:29675"
                     /db_xref="RGD:61874"
     exon            1..149
                     /gene="Psmb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..664
                     /gene="Psmb2"
                     /EC_number="3.4.25.1"
                     /note="macropain subunit C7-I; beta-4; proteasome subunit
                     beta-4; proteasome component C7-I; multicatalytic
                     endopeptidase complex subunit C7-I; proteasome (prosome,
                     macropain) subunit, beta type 2; proteasome beta 2
                     subunit; proteasome subunit beta 2"
                     /codon_start=1
                     /product="proteasome subunit beta type-2"
                     /protein_id="NP_058980.1"
                     /db_xref="GeneID:29675"
                     /db_xref="RGD:61874"
                     /translation="MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILL
                     LCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNL
                     LLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELL
                     RKCLEELQKRFILNLPTFSVRVIDKDGIHNLENITFTKRSS"
     exon            150..272
                     /gene="Psmb2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..343
                     /gene="Psmb2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..506
                     /gene="Psmb2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..556
                     /gene="Psmb2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..792
                     /gene="Psmb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgtacccg ggaagtcccc gtgtgtgtgt accttgcagc ctcccgcttc ccggaaccat
       61 ggagtacctc attggcatcc agggtcctga ctatgtcctg gtcgcttctg atcgggtggc
      121 cgccagcaat attgtccaga tgaaggacga tcatgacaag atgtttaaga tgagtgaaaa
      181 aatcttactc ctatgtgttg gagaggctgg agacactgta cagtttgcag aatatatcca
      241 gaaaaacgtg cagctttata aaatgcggaa tggatatgaa ttgtccccca cagcagcagc
      301 taatttcaca cgccgaaacc tggccgactg tcttcggagt cggacccctt atcatgtgaa
      361 cctcctcctg gctggctatg acgagcatga ggggccagca ctttactaca tggactacct
      421 agcagccttg gccaaggctc cttttgcagc tcatggctat ggtgccttcc tgaccctcag
      481 catccttgac cgatactaca caccaactat ctcacgtgag agggcagtgg agcttcttag
      541 gaagtgtctg gaggagctcc agaagcgctt catcttgaat ctgcccacct tcagcgttcg
      601 ggtcattgac aaagatggca tccacaatct ggagaacatt accttcacta agcggagttc
      661 ctaacatcat gttcttccct cccacttacc agggaccttt ttttgatggg ttccttttat
      721 ttttttctac tcttttgacg ttcactctca atagatggtt aattcaaaat aaagctgaac
      781 acagctaaat tg
//
