LOCUS       NM_017283               1136 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus proteasome 20S subunit alpha 6 (Psma6), mRNA.
ACCESSION   NM_017283
VERSION     NM_017283.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1136)
  AUTHORS   Feng,Y., Jin,M.Y., Liu,D.W. and Wei,L.
  TITLE     Proteasome subunit-alpha type-6 protein is post-transcriptionally
            repressed by the microRNA-4490 in diabetic nephropathy
  JOURNAL   Biosci Rep 38 (5) (2018)
   PUBMED   30287505
  REMARK    GeneRIF: PSMA6 mRNA is post-transcriptionally regulated by
            miRNA-4490, whose expression is inversely correlated to PSMA6
            protein expression.
            Erratum:[Biosci Rep. 2019 Jan 11;39(1):BSR-20180815_COR. doi:
            10.1042/BSR-20180815_COR.. PMID: 30635449]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1136)
  AUTHORS   Wu,W., Sahara,K., Hirayama,S., Zhao,X., Watanabe,A., Hamazaki,J.,
            Yashiroda,H. and Murata,S.
  TITLE     PAC1-PAC2 proteasome assembly chaperone retains the core
            alpha4-alpha7 assembly intermediates in the cytoplasm
  JOURNAL   Genes Cells 23 (10), 839-848 (2018)
   PUBMED   30133132
REFERENCE   3  (bases 1 to 1136)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1136)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1136)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   6  (bases 1 to 1136)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   7  (bases 1 to 1136)
  AUTHORS   De Conto,F., Pilotti,E., Razin,S.V., Ferraglia,F., Geraud,G.,
            Arcangeletti,C. and Scherrer,K.
  TITLE     In mouse myoblasts nuclear prosomes are associated with the nuclear
            matrix and accumulate preferentially in the perinucleolar areas
  JOURNAL   J Cell Sci 113 (Pt 13), 2399-2407 (2000)
   PUBMED   10852819
REFERENCE   8  (bases 1 to 1136)
  AUTHORS   Kopp,F., Hendil,K.B., Dahlmann,B., Kristensen,P., Sobek,A. and
            Uerkvitz,W.
  TITLE     Subunit arrangement in the human 20S proteasome
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2939-2944 (1997)
   PUBMED   9096325
REFERENCE   9  (bases 1 to 1136)
  AUTHORS   Bey,F., Silva Pereira,I., Coux,O., Viegas-Pequignot,E., Recillas
            Targa,F., Nothwang,H.G., Dutrillaux,B. and Scherrer,K.
  TITLE     The prosomal RNA-binding protein p27K is a member of the alpha-type
            human prosomal gene family
  JOURNAL   Mol Gen Genet 237 (1-2), 193-205 (1993)
   PUBMED   7681138
REFERENCE   10 (bases 1 to 1136)
  AUTHORS   Tamura,T., Shimbara,N., Aki,M., Ishida,N., Bey,F., Scherrer,K.,
            Tanaka,K. and Ichihara,A.
  TITLE     Molecular cloning of cDNAs for rat proteasomes: deduced primary
            structures of four other subunits
  JOURNAL   J Biochem 112 (4), 530-534 (1992)
   PUBMED   1491007
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062232.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017283.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062232.1, CV114514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1136              BC062232.1         2-1137
FEATURES             Location/Qualifiers
     source          1..1136
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..1136
                     /gene="Psma6"
                     /note="proteasome 20S subunit alpha 6"
                     /db_xref="GeneID:29673"
                     /db_xref="RGD:61849"
     exon            1..137
                     /gene="Psma6"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..802
                     /gene="Psma6"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit alpha 6; macropain iota chain;
                     proteasome iota chain; multicatalytic endopeptidase
                     complex iota chain; proteasome alpha 6 subunit; proteasome
                     (prosome, macropain) subunit, alpha type 6; alpha-1;
                     proteasome subunit alpha-1"
                     /codon_start=1
                     /product="proteasome subunit alpha type-6"
                     /protein_id="NP_058979.1"
                     /db_xref="GeneID:29673"
                     /db_xref="RGD:61849"
                     /translation="MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRG
                     KDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWK
                     YKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYY
                     CGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVG
                     VVTVENPKFRILTEAEIDAHLVALAERD"
     exon            138..232
                     /gene="Psma6"
                     /inference="alignment:Splign:2.1.0"
     exon            233..314
                     /gene="Psma6"
                     /inference="alignment:Splign:2.1.0"
     exon            315..470
                     /gene="Psma6"
                     /inference="alignment:Splign:2.1.0"
     exon            471..649
                     /gene="Psma6"
                     /inference="alignment:Splign:2.1.0"
     exon            650..744
                     /gene="Psma6"
                     /inference="alignment:Splign:2.1.0"
     exon            745..963
                     /gene="Psma6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtgtgtg tgtgtgtgtg cgctacgggg tgtagactgt gtctgaaata gcgggaacgc
       61 catgtcccgt ggttccagcg ccggttttga ccggcacatt actattttct ctcccgaggg
      121 ccgactctac caagtagaat atgcttttaa ggctattaac cagggtggac ttacatctgt
      181 agctgtcaga ggaaaggact gcgcagttat tgtcacacag aagaaagtac ctgacaaact
      241 actggattcc agcaccgtga ctcacttatt caagataacg gaaaacattg gctgtgtgat
      301 gacaggaatg acagctgaca gcagatccca ggtacagagg gcacgctatg aagcagctaa
      361 ctggaaatac aaatatggct atgagattcc tgtggacatg ctgtgtaaaa gaattgctga
      421 tatttctcaa gtctacacac agaatgctga aatgaggcca cttggttgtt gtatgatttt
      481 aattggtata gatgaagagc aaggccctca agtgtacaag tgtgatcctg caggctacta
      541 ctgtggcttt aaagccaccg cagcaggagt gaagcagaca gagtcaacca gcttcctcga
      601 aaaaaaagtg aagaagaaat ttgattggac atttgaacag acagtggaaa ctgcaatcac
      661 atgcctgtct actgttctgt cgattgattt caaaccttca gaaatcgaag ttggagtagt
      721 tacagttgaa aatcctaaat tcaggattct tacagaagca gagattgacg ctcaccttgt
      781 ggctctagca gagagagact gaacactctt atcagcttac cagatccatg atgccatgtg
      841 cctatgtgtt tagtaacaac aaaccgacat cttagaggcc ctggattgaa gatggaaact
      901 ctcccactcc tcctgccact gactggttag gactctgtat aaataaaaca gtgcttttgg
      961 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1021 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1081 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
