LOCUS       NP_058979                246 aa            linear   ROD 10-FEB-2025
DEFINITION  proteasome subunit alpha type-6 [Rattus norvegicus].
ACCESSION   NP_058979
VERSION     NP_058979.1
DBSOURCE    REFSEQ: accession NM_017283.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 246)
  AUTHORS   Feng,Y., Jin,M.Y., Liu,D.W. and Wei,L.
  TITLE     Proteasome subunit-alpha type-6 protein is post-transcriptionally
            repressed by the microRNA-4490 in diabetic nephropathy
  JOURNAL   Biosci Rep 38 (5) (2018)
   PUBMED   30287505
  REMARK    GeneRIF: PSMA6 mRNA is post-transcriptionally regulated by
            miRNA-4490, whose expression is inversely correlated to PSMA6
            protein expression.
            Erratum:[Biosci Rep. 2019 Jan 11;39(1):BSR-20180815_COR. doi:
            10.1042/BSR-20180815_COR.. PMID: 30635449]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 246)
  AUTHORS   Wu,W., Sahara,K., Hirayama,S., Zhao,X., Watanabe,A., Hamazaki,J.,
            Yashiroda,H. and Murata,S.
  TITLE     PAC1-PAC2 proteasome assembly chaperone retains the core
            alpha4-alpha7 assembly intermediates in the cytoplasm
  JOURNAL   Genes Cells 23 (10), 839-848 (2018)
   PUBMED   30133132
REFERENCE   3  (residues 1 to 246)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 246)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (residues 1 to 246)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   6  (residues 1 to 246)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   7  (residues 1 to 246)
  AUTHORS   De Conto,F., Pilotti,E., Razin,S.V., Ferraglia,F., Geraud,G.,
            Arcangeletti,C. and Scherrer,K.
  TITLE     In mouse myoblasts nuclear prosomes are associated with the nuclear
            matrix and accumulate preferentially in the perinucleolar areas
  JOURNAL   J Cell Sci 113 (Pt 13), 2399-2407 (2000)
   PUBMED   10852819
REFERENCE   8  (residues 1 to 246)
  AUTHORS   Kopp,F., Hendil,K.B., Dahlmann,B., Kristensen,P., Sobek,A. and
            Uerkvitz,W.
  TITLE     Subunit arrangement in the human 20S proteasome
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2939-2944 (1997)
   PUBMED   9096325
REFERENCE   9  (residues 1 to 246)
  AUTHORS   Bey,F., Silva Pereira,I., Coux,O., Viegas-Pequignot,E., Recillas
            Targa,F., Nothwang,H.G., Dutrillaux,B. and Scherrer,K.
  TITLE     The prosomal RNA-binding protein p27K is a member of the alpha-type
            human prosomal gene family
  JOURNAL   Mol Gen Genet 237 (1-2), 193-205 (1993)
   PUBMED   7681138
REFERENCE   10 (residues 1 to 246)
  AUTHORS   Tamura,T., Shimbara,N., Aki,M., Ishida,N., Bey,F., Scherrer,K.,
            Tanaka,K. and Ichihara,A.
  TITLE     Molecular cloning of cDNAs for rat proteasomes: deduced primary
            structures of four other subunits
  JOURNAL   J Biochem 112 (4), 530-534 (1992)
   PUBMED   1491007
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062232.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062232.1, CV114514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..246
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     Protein         1..246
                     /product="proteasome subunit alpha type-6"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit alpha 6; macropain iota chain;
                     proteasome iota chain; multicatalytic endopeptidase
                     complex iota chain; proteasome alpha 6 subunit; proteasome
                     (prosome, macropain) subunit, alpha type 6; alpha-1;
                     proteasome subunit alpha-1"
                     /calculated_mol_wt=27268
     Site            5
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P60901.1)"
     Region          8..220
                     /region_name="proteasome_alpha_type_6"
                     /note="The 20S proteasome, multisubunit proteolytic
                     complex, is the central enzyme of nonlysosomal protein
                     degradation in both the cytosol and nucleus. It is
                     composed of 28 subunits arranged as four homoheptameric
                     rings that stack on top of one another forming...;
                     cd03754"
                     /db_xref="CDD:239723"
     Site            order(11..14,16..17,19..20,24,27,30..31,34,43,58,60..61,
                     84..86,88..89,120,123,126..127,130..134,152,157..158,160,
                     162..163,165)
                     /site_type="other"
                     /note="alpha subunit interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239723"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (P60901.1)"
     Site            order(37,53,55,68,170)
                     /site_type="active"
                     /db_xref="CDD:239723"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (P60901.1)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (P60901.1)"
     Site            102
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (P60901.1)"
     Site            104
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (P60901.1)"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9QUM9; propagated from
                     UniProtKB/Swiss-Prot (P60901.1)"
     CDS             1..246
                     /gene="Psma6"
                     /coded_by="NM_017283.3:62..802"
                     /db_xref="GeneID:29673"
                     /db_xref="RGD:61849"
ORIGIN      
        1 msrgssagfd rhitifspeg rlyqveyafk ainqggltsv avrgkdcavi vtqkkvpdkl
       61 ldsstvthlf kitenigcvm tgmtadsrsq vqraryeaan wkykygyeip vdmlckriad
      121 isqvytqnae mrplgccmil igideeqgpq vykcdpagyy cgfkataagv kqtestsfle
      181 kkvkkkfdwt feqtvetait clstvlsidf kpseievgvv tvenpkfril teaeidahlv
      241 alaerd
//
