LOCUS       NM_017280               1993 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus proteasome 20S subunit alpha 3 (Psma3), mRNA.
ACCESSION   NM_017280
VERSION     NM_017280.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Brehm,A., Liu,Y., Sheikh,A., Marrero,B., Omoyinmi,E., Zhou,Q.,
            Montealegre,G., Biancotto,A., Reinhardt,A., Almeida de Jesus,A.,
            Pelletier,M., Tsai,W.L., Remmers,E.F., Kardava,L., Hill,S., Kim,H.,
            Lachmann,H.J., Megarbane,A., Chae,J.J., Brady,J., Castillo,R.D.,
            Brown,D., Casano,A.V., Gao,L., Chapelle,D., Huang,Y., Stone,D.,
            Chen,Y., Sotzny,F., Lee,C.C., Kastner,D.L., Torrelo,A.,
            Zlotogorski,A., Moir,S., Gadina,M., McCoy,P., Wesley,R.,
            Rother,K.I., Hildebrand,P.W., Brogan,P., Kruger,E.,
            Aksentijevich,I. and Goldbach-Mansky,R.
  TITLE     Additive loss-of-function proteasome subunit mutations in
            CANDLE/PRAAS patients promote type I IFN production
  JOURNAL   J Clin Invest 125 (11), 4196-4211 (2015)
   PUBMED   26524591
  REMARK    Erratum:[J Clin Invest. 2016 Feb;126(2):795. doi:
            10.1172/JCI86020.. Rother, Kristina [corrected to Rother, Kristina
            I]. PMID: 26829627]
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Parfitt,D.A., Michael,G.J., Vermeulen,E.G., Prodromou,N.V.,
            Webb,T.R., Gallo,J.M., Cheetham,M.E., Nicoll,W.S., Blatch,G.L. and
            Chapple,J.P.
  TITLE     The ataxia protein sacsin is a functional co-chaperone that
            protects against polyglutamine-expanded ataxin-1
  JOURNAL   Hum Mol Genet 18 (9), 1556-1565 (2009)
   PUBMED   19208651
REFERENCE   6  (bases 1 to 1993)
  AUTHORS   Arndt,V., Daniel,C., Nastainczyk,W., Alberti,S. and Hohfeld,J.
  TITLE     BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin
            ligase CHIP
  JOURNAL   Mol Biol Cell 16 (12), 5891-5900 (2005)
   PUBMED   16207813
REFERENCE   7  (bases 1 to 1993)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   8  (bases 1 to 1993)
  AUTHORS   Sorimachi,H., Tsukahara,T., Kawasaki,H., Ishiura,S., Emori,Y.,
            Sugita,H. and Suzuki,K.
  TITLE     Molecular cloning of cDNAs for two subunits of rat multicatalytic
            proteinase. Existence of N-terminal conserved and C-terminal
            diverged sequences among subunits
  JOURNAL   Eur J Biochem 193 (3), 775-781 (1990)
   PUBMED   2249692
REFERENCE   9  (bases 1 to 1993)
  AUTHORS   Tanaka,K., Kanayama,H., Tamura,T., Lee,D.H., Kumatori,A.,
            Fujiwara,T., Ichihara,A., Tokunaga,F., Aruga,R. and Iwanaga,S.
  TITLE     cDNA cloning and sequencing of component C8 of proteasomes from rat
            hepatoma cells
  JOURNAL   Biochem Biophys Res Commun 171 (2), 676-683 (1990)
   PUBMED   2403356
REFERENCE   10 (bases 1 to 1993)
  AUTHORS   Tokunaga,F., Aruga,R., Iwanaga,S., Tanaka,K., Ichihara,A., Takao,T.
            and Shimonishi,Y.
  TITLE     The NH2-terminal residues of rat liver proteasome (multicatalytic
            proteinase complex) subunits, C2, C3 and C8, are N alpha-acetylated
  JOURNAL   FEBS Lett 263 (2), 373-375 (1990)
   PUBMED   2335242
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081817.1.
            
            On Sep 19, 2004 this sequence version replaced NM_017280.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081817.1, FQ224319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1993
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /note="proteasome 20S subunit alpha 3"
                     /db_xref="GeneID:29670"
                     /db_xref="RGD:61844"
     exon            1..23
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..770
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit C8; multicatalytic proteinase
                     subunit K; macropain subunit C8; alpha-7; proteasome
                     (prosome, macropain) subunit, alpha type 3; proteasome
                     subunit K; proteasome component C8; multicatalytic
                     endopeptidase complex subunit C8; proteasome subunit alpha
                     3; proteasome subunit alpha-7"
                     /codon_start=1
                     /product="proteasome subunit alpha type-3"
                     /protein_id="NP_058976.1"
                     /db_xref="GeneID:29670"
                     /db_xref="RGD:61844"
                     /translation="MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKD
                     GVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSN
                     FGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYG
                     YWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVG
                     ELTKGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM"
     exon            24..106
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            107..230
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            231..332
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            333..406
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            407..479
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            480..545
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            546..592
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            593..660
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            661..725
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1967
                     /gene="Psma3"
                     /gene_synonym="Psma3l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatgagctc cattggcact gggtatgacc tgtcagcctc tacattctct cctgatggaa
       61 gagttttcca agttgaatat gctatgaagg ctgtggaaaa cagtagtaca gctattggga
      121 tcagatgtaa agatggtgtt gtgtttgggg tagaaaaact agtcctttct aaactttatg
      181 aagaaggctc caataaacgt cttttcaatg ttgatcgaca tgttggaatg gcagtggcag
      241 gtttgttggc agatgctcgt tccttggcag acatagcaag agaagaagcg tccaacttta
      301 ggtctaactt tggctataac attcctctaa aacatcttgc agacagagtg gccatgtatg
      361 tacacgcgta tacactctac agtgctgtta gaccttttgg ctgcagtttc atgttggggt
      421 cttacagtgt gaatgatggt gcacagctct atatgatcga tccatcaggt gtttcatatg
      481 gttactgggg ctgtgccatt ggcaaagcca ggcaagctgc aaagacagaa atagaaaagc
      541 ttcagatgaa ggaaatgacc tgccgtgatg tagttaaaga agttgcaaaa ataatttaca
      601 tagtacatga tgaagttaag gataaagctt ttgaactaga gctcagctgg gttggtgaat
      661 taactaaagg aagacatgaa attgttccca aagacgtaag agaggaagca gagaaatatg
      721 ccaaggaatc tttgaaggaa gaagatgaat cagatgacga caatatgtaa catttcacca
      781 tcctctggtg tccatttctg tgacagttgc atatggctag caccatggat tatatatacc
      841 cactgaccaa ttttcattaa attttgtctt ataaacattg ttgggtaatt gaggatatct
      901 gcgttatatt aaaatgtaga ttcatgtttg attagaaatt ctaggaactg ggcctggaga
      961 gatggctcag cagttaagag ctgctcttcc aggggacata ggttcaattc ccagcacccg
     1021 catggcagct cacacctgtt tgtaactcta gctccaggtc tctgacacct agacacagag
     1081 gtacttgcag gcaaaacacc aatgaatata aaataaaaat aaatgatata tatatttaca
     1141 catataacaa gtatatacaa atatgtatat tatacagaca catgtgtgtg tatatacata
     1201 taaattcttg gtgctattct ggtgtggtag tatatgtctt taatcctagt actctggagg
     1261 cagaggcagg tggatctctt gagttcaagg ctagtattta aaaacaaaaa caaatgtagt
     1321 gcccagacta aggctgaaag attgagccca caagtcaatt tacaattcca ttttgtttta
     1381 actagaatta aaagaataat tttagatttt ttttttcttt ttttcagagc tggggaccga
     1441 acccagggcc ttgcgcttcc taggcaagcg ctctaccact aagctaaatc cccaacccct
     1501 tagatttatt tttatttttt gcatgtttat gtatattaca gtgccatgcc tggtgctcat
     1561 ggaggtcaaa agaatgcttt aatctagaac taaagttatg gaggactgtg aatcatgtat
     1621 gttcgaaact gaacttgggt cctgtgtaag agcaacacgt cctcttaacc actgagccat
     1681 ctctccagcc ctctttgact agaatgatca tattctactg tggttcttgt ataatgtttt
     1741 gtttaatgta gggatatcct gtaaccacta ttgaggacta acctgccttt tgtggaaaat
     1801 gtgacatatt ctaatttgac atcaatacag acaacattta ttttcagact gcataaatat
     1861 cttatgactg gaaattatct tgatattggc acctgaaaca aaaacttaaa agttccaaac
     1921 tgggcttaaa tatttcatgt aataaaatgt ttatagtact tatctgaaaa aaaaaaaaaa
     1981 aaaaaaaaaa aaa
//
