LOCUS       NM_175765               2559 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PC4 and SRSF1 interacting protein 1 (Psip1),
            mRNA.
ACCESSION   NM_175765
VERSION     NM_175765.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2559)
  AUTHORS   Tsutsui,K.M., Sano,K., Hosoya,O., Miyamoto,T. and Tsutsui,K.
  TITLE     Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel
            DNA-binding domain
  JOURNAL   Nucleic Acids Res 39 (12), 5067-5081 (2011)
   PUBMED   21345933
REFERENCE   5  (bases 1 to 2559)
  AUTHORS   Hendrix,J., Gijsbers,R., De Rijck,J., Voet,A., Hotta,J.,
            McNeely,M., Hofkens,J., Debyser,Z. and Engelborghs,Y.
  TITLE     The transcriptional co-activator LEDGF/p75 displays a dynamic
            scan-and-lock mechanism for chromatin tethering
  JOURNAL   Nucleic Acids Res 39 (4), 1310-1325 (2011)
   PUBMED   20974633
REFERENCE   6  (bases 1 to 2559)
  AUTHORS   Nishizawa,Y., Usukura,J., Singh,D.P., Chylack,L.T. Jr. and
            Shinohara,T.
  TITLE     Spatial and temporal dynamics of two alternatively spliced
            regulatory factors, lens epithelium-derived growth factor
            (ledgf/p75) and p52, in the nucleus
  JOURNAL   Cell Tissue Res 305 (1), 107-114 (2001)
   PUBMED   11512661
REFERENCE   7  (bases 1 to 2559)
  AUTHORS   Sharma,P., Singh,D.P., Fatma,N., Chylack,L.T. Jr. and Shinohara,T.
  TITLE     Activation of LEDGF gene by thermal-and oxidative-stresses
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1320-1324 (2000)
   PUBMED   11027629
REFERENCE   8  (bases 1 to 2559)
  AUTHORS   Ge,H., Si,Y. and Wolffe,A.P.
  TITLE     A novel transcriptional coactivator, p52, functionally interacts
            with the essential splicing factor ASF/SF2
  JOURNAL   Mol Cell 2 (6), 751-759 (1998)
   PUBMED   9885563
REFERENCE   9  (bases 1 to 2559)
  AUTHORS   Ge,H., Si,Y. and Roeder,R.G.
  TITLE     Isolation of cDNAs encoding novel transcription coactivators p52
            and p75 reveals an alternate regulatory mechanism of
            transcriptional activation
  JOURNAL   EMBO J 17 (22), 6723-6729 (1998)
   PUBMED   9822615
REFERENCE   10 (bases 1 to 2559)
  AUTHORS   Tsutsui,K., Tsutsui,K. and Muller,M.T.
  TITLE     The nuclear scaffold exhibits DNA-binding sites selective for
            supercoiled DNA
  JOURNAL   J Biol Chem 263 (15), 7235-7241 (1988)
   PUBMED   3366776
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF339084.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175765.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF339084.1, AB285525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..2559
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="PC4 and SRSF1 interacting protein 1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
     exon            1..172
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1687
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /note="supercoiled DNA binding protein 75; PC4 and SFRS1
                     interacting protein 2; lens epithelium-derived growth
                     factor; PC4 and SFRS1 interacting protein 1"
                     /codon_start=1
                     /product="PC4 and SFRS1-interacting protein"
                     /protein_id="NP_786941.1"
                     /db_xref="GeneID:313323"
                     /db_xref="RGD:631439"
                     /translation="MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFF
                     FGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQVSTKQS
                     NASSDVEAEEKETSVSKEDTDQEEKASNEDVTKAADITTPKAARRGRKRKAEKQVDTE
                     EAGVVTAATASNVKASPKRGRPAATEVKIPKPRGRPKVVKQPCPSESDMVIDEDKSKK
                     KGPEEKPPKKQLKKEEEGQKEEEKPRKEPDKKEGKKEVESKRKNLAKPGVTSTSDSEE
                     DDDQEGEKKRKGGRHFQAAHRRNMLKGQHEKEAADRKRKQEEQMETEQQTKDEGKKPE
                     VKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHT
                     EMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEE
                     ANKTKDQGKKGPNKKLEKEQTGTKSLNGGSDAQESNHPQHNGDSAEESKDSREAGSKT
                     KTPGEEREAEVSLKESTLDN"
     exon            173..249
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            250..388
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            389..493
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            494..556
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            557..650
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            651..726
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            727..952
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1071
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1127
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1198
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1300
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1514
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1626
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..2542
                     /gene="Psip1"
                     /gene_synonym="Ledgf; Psip2; SBP75"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcccgcca gtcccagctc gcgtcggtgc tcgcatctac tgatcgcggc tgcgctgctc
       61 ccccttctgg tcttgggact cccggcgtcg cccctcaaac atgactcgcg atttcaaacc
      121 tggagacctc atcttcgcca agatgaaagg ttatcctcat tggccagctc gagtagatga
      181 agttcctgat ggagctgtaa aaccacccac aaacaaacta cccattttct tttttggaac
      241 ccacgagact gcttttttag gaccaaagga catatttcct tattcagaaa ataaggaaaa
      301 gtatggcaaa ccaaataaac gaaaaggttt taatgaagga ttgtgggaga tagataacaa
      361 tccaaaagtg aaattttcaa gtcaacaggt atcaaccaaa cagtcaaatg catcatctga
      421 tgttgaagcg gaagaaaaag aaactagtgt ttcaaaggaa gatactgatc aggaagaaaa
      481 agccagcaat gaagatgtga ctaaagcagc tgacataacc actccaaaag ctgccaggcg
      541 aggaagaaag agaaaggctg aaaaacaagt agacactgaa gaggcaggag tggtgactgc
      601 agcgaccgct tccaatgtga aagcaagtcc taagagagga cggcctgcag ctactgaagt
      661 caagattcca aaaccaagag gcagacctaa agtggtaaaa cagccctgtc cgtcagaaag
      721 tgacatggtt attgatgaag acaaaagtaa aaaaaagggg ccagaggaaa aaccacccaa
      781 aaagcagctt aaaaaggagg aagaaggcca aaaggaagaa gagaagccaa gaaaagaacc
      841 agataagaaa gaggggaaga aagaagtcga atctaaacgg aaaaatttag ctaaaccagg
      901 ggttacgtca acctctgatt cagaagaaga tgatgatcaa gaaggtgaaa agaagagaaa
      961 gggtggaaga cacttccagg ctgctcacag gaggaacatg ctaaaaggcc aacatgagaa
     1021 agaagctgca gatcggaaac gcaagcagga ggaacaaatg gagactgagc agcagactaa
     1081 agatgaagga aagaagccag aagttaagaa agtggagaag aagcgagaaa catcaatgga
     1141 ttctcgactt caaaggatac atgctgaaat taaaaattca ctcaaaattg ataatctaga
     1201 tgtgaacaga tgcattgagg cactggatga actcgcttca cttcaggtaa caatgcaaca
     1261 agctcagaaa cacacagaga tgatcacaac cctgaagaaa atccggcggt tcaaagtcag
     1321 tcaagttatc atggagaagt ctacaatgtt gtataacaag tttaagaata tgtttttggt
     1381 tggtgaaggg gattccgtca tcacccaagt gctaaacaaa tctcttgctg aacaaagaca
     1441 gcatgaggaa gcaaataaaa ccaaagatca agggaagaaa gggccaaaca aaaagctaga
     1501 aaaggaacaa acaggtacaa agagcctaaa tggaggatct gatgctcagg aaagtaatca
     1561 tccacaacat aatggtgaca gtgcggaaga aagcaaagac agccgtgagg ccggcagtaa
     1621 gacaaagaca cctggagaag agagagaggc tgaagtatct ctgaaggagt ctaccctaga
     1681 taactaggtc tgcagacttc agatgtaaag agtgtgagaa gtctgttgtg agtggcttca
     1741 tttgaaatac ttaggctgtt gaaaggttta aagttttata agcataggtt ttgatgttta
     1801 agtagttggg ggatagaaaa accctttata tttgtgtaaa agtcaattat tgctaatttt
     1861 ctgtgtgcag tattaacagc tccgccatct agtttgagta aggaaaccta cttagaaagg
     1921 ttaacctgct ttatagacat gactgtagtg aatttttggt tagtgtgtca atgtgtaatt
     1981 agtagtaggg cagttacatt ttaaaactgc tacttgtata aatctttcct cttttcccaa
     2041 atactgtgcg ttttgtgcat agtttttaca aatattggat ttaccagact gtcttttcac
     2101 tgtgtgggtg ttttagaagt tgagcatttt tatggatgat aaaatgaatg ttacttctaa
     2161 gtactcactc ccttttatca acagttataa cctcagtcca ttgtgctaca ttagcgtgcc
     2221 tctttgtaat aatgtgtagt atgacagcta gatgcctatt gggttgttat agaaggtaca
     2281 aatttgttta cttttgaaag taatttagtt ttaggactgg gatttcagtg gtgttagaac
     2341 tagagagaac agactggtta tatatacata taggaagtcc atctacaatc ctttataaag
     2401 gtaccaatca cacaaaccta aaattagttt gttttaatct tatactcatt aaggtgtgtt
     2461 tttttttctt tcttttttaa ttagaatcaa tccatgatgc ttataagtaa taaataagga
     2521 aattaaccta attgaagaca tgaaaaaaaa aaaaaaaaa
//
