LOCUS       NM_001008764             572 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus presenilin enhancer gamma secretase subunit
            (Psenen), mRNA.
ACCESSION   NM_001008764 XM_214897
VERSION     NM_001008764.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 572)
  AUTHORS   Bai,X.C., Yan,C., Yang,G., Lu,P., Ma,D., Sun,L., Zhou,R.,
            Scheres,S.H.W. and Shi,Y.
  TITLE     An atomic structure of human gamma-secretase
  JOURNAL   Nature 525 (7568), 212-217 (2015)
   PUBMED   26280335
REFERENCE   2  (bases 1 to 572)
  AUTHORS   Lu,P., Bai,X.C., Ma,D., Xie,T., Yan,C., Sun,L., Yang,G., Zhao,Y.,
            Zhou,R., Scheres,S.H.W. and Shi,Y.
  TITLE     Three-dimensional structure of human gamma-secretase
  JOURNAL   Nature 512 (7513), 166-170 (2014)
   PUBMED   25043039
REFERENCE   3  (bases 1 to 572)
  AUTHORS   Mason,M.N. and Mahoney,M.J.
  TITLE     Inhibition of gamma-secretase activity promotes differentiation of
            embryonic pancreatic precursor cells into functional islet-like
            clusters in poly(ethylene glycol) hydrogel culture
  JOURNAL   Tissue Eng Part A 16 (8), 2593-2603 (2010)
   PUBMED   20236034
  REMARK    GeneRIF: These results indicate that concerted differentiation of
            pancreatic precursor cell aggregates into functionally mature
            islet-like clusters can be achieved in poly(ethylene glycol)-based
            hydrogel cultures.
REFERENCE   4  (bases 1 to 572)
  AUTHORS   Franberg,J., Karlstrom,H., Winblad,B., Tjernberg,L.O. and
            Frykman,S.
  TITLE     gamma-Secretase dependent production of intracellular domains is
            reduced in adult compared to embryonic rat brain membranes
  JOURNAL   PLoS One 5 (3), e9772 (2010)
   PUBMED   20333303
  REMARK    GeneRIF: analysis of gamma-secretase cleavage of five substrates,
            APP, Notch1, N-cadherin, ephrinB and p75 neurotrophin receptor
            (p75-NTR) in membranes isolated from embryonic, young or old adult
            rat brains
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 572)
  AUTHORS   Zhao,G., Liu,Z., Ilagan,M.X. and Kopan,R.
  TITLE     Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and
            amyloid precursor protein in the absence of nicastrin
  JOURNAL   J Neurosci 30 (5), 1648-1656 (2010)
   PUBMED   20130175
REFERENCE   6  (bases 1 to 572)
  AUTHORS   Frykman,S., Hur,J.Y., Franberg,J., Aoki,M., Winblad,B.,
            Nahalkova,J., Behbahani,H. and Tjernberg,L.O.
  TITLE     Synaptic and endosomal localization of active gamma-secretase in
            rat brain
  JOURNAL   PLoS One 5 (1), e8948 (2010)
   PUBMED   20126630
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 572)
  AUTHORS   Fiuza,U.M. and Arias,A.M.
  TITLE     Cell and molecular biology of Notch
  JOURNAL   J Endocrinol 194 (3), 459-474 (2007)
   PUBMED   17761886
  REMARK    Review article
REFERENCE   8  (bases 1 to 572)
  AUTHORS   Hansson,C.A., Frykman,S., Farmery,M.R., Tjernberg,L.O.,
            Nilsberth,C., Pursglove,S.E., Ito,A., Winblad,B., Cowburn,R.F.,
            Thyberg,J. and Ankarcrona,M.
  TITLE     Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase
            complexes in mitochondria
  JOURNAL   J Biol Chem 279 (49), 51654-51660 (2004)
   PUBMED   15456764
  REMARK    GeneRIF: Nicastrin, presenilin 1, APH-1, and PEN-2 form an active
            gamma-secretase complex expressed in mitochondria.
REFERENCE   9  (bases 1 to 572)
  AUTHORS   Fraering,P.C., Ye,W., Strub,J.M., Dolios,G., LaVoie,M.J.,
            Ostaszewski,B.L., van Dorsselaer,A., Wang,R., Selkoe,D.J. and
            Wolfe,M.S.
  TITLE     Purification and characterization of the human gamma-secretase
            complex
  JOURNAL   Biochemistry 43 (30), 9774-9789 (2004)
   PUBMED   15274632
REFERENCE   10 (bases 1 to 572)
  AUTHORS   Takasugi,N., Tomita,T., Hayashi,I., Tsuruoka,M., Niimura,M.,
            Takahashi,Y., Thinakaran,G. and Iwatsubo,T.
  TITLE     The role of presenilin cofactors in the gamma-secretase complex
  JOURNAL   Nature 422 (6930), 438-441 (2003)
   PUBMED   12660785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100104.1.
            
            On Aug 7, 2005 this sequence version replaced NM_001008764.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100104.1, CO565158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00155337
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..572
                     /gene="Psenen"
                     /gene_synonym="RGD1312037"
                     /note="presenilin enhancer gamma secretase subunit"
                     /db_xref="GeneID:292788"
                     /db_xref="RGD:1312037"
     exon            1..25
                     /gene="Psenen"
                     /gene_synonym="RGD1312037"
                     /inference="alignment:Splign:2.1.0"
     exon            26..170
                     /gene="Psenen"
                     /gene_synonym="RGD1312037"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..415
                     /gene="Psenen"
                     /gene_synonym="RGD1312037"
                     /note="LRRGT00140 mRNA; presenilin enhancer protein 2;
                     liver regeneration-related protein LRRGT00140; presenilin
                     enhancer 2 homolog"
                     /codon_start=1
                     /product="gamma-secretase subunit PEN-2"
                     /protein_id="NP_001008764.1"
                     /db_xref="GeneID:292788"
                     /db_xref="RGD:1312037"
                     /translation="MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFKEAFFA
                     PAYTEQSQIKGYVWRSAVGFLFWVIVLTTWITIFQIYRPRWGALGDYLSFTIPLGTP"
     exon            171..275
                     /gene="Psenen"
                     /gene_synonym="RGD1312037"
                     /inference="alignment:Splign:2.1.0"
     exon            276..535
                     /gene="Psenen"
                     /gene_synonym="RGD1312037"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggcagaag gggtaaaccc cactggggcg tgattgttcg tgatcttgtg cctgtcattt
       61 gggtcttgct ctgcaagcca aattagtgcc accaggctcc agcgcaacta tgaacttaga
      121 gcgggtgtcc aatgaggaga agttgaacct gtgccggaag tactatcttg gtggatttgc
      181 atttctgcct tttctttggt tggtcaacat tttctggttc ttcaaagagg ccttcttcgc
      241 tccagcctac acagagcaga gccaaatcaa aggctatgtt tggcgctcag ctgtgggctt
      301 cctcttctgg gtgattgttc tcaccacctg gatcaccatc ttccagatct accggccccg
      361 ctggggtgct cttggggact acctctcctt caccattccc ctgggcactc cctgacaact
      421 tcacgagctg ttctttctcc caggatgggc ttttctgttc taagttttct ctcagaccct
      481 gaagacatct gtttcccatt tcccatctgc tccaataaag gaccctaact ttaaaaaaaa
      541 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
