LOCUS       NM_031087               1628 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus presenilin 2 (Psen2), mRNA.
ACCESSION   NM_031087
VERSION     NM_031087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1628)
  AUTHORS   Li,Y., Zhang,T., Zhou,Y., Sun,Y., Cao,Y., Chang,X., Zhu,Y. and
            Han,X.
  TITLE     A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and
            miR-34a mediates glucotoxicity induced-pancreatic beta cell
            apoptosis
  JOURNAL   Sci Rep 6, 36136 (2016)
   PUBMED   27804997
  REMARK    GeneRIF: Downregulating the expression of miR-375, miR-30a, and
            miR-34a restored PSEN1, PSEN2, and NICD1 production and prevented
            glucotoxicity-induced impairment of the beta cells.Our findings
            demonstrated that miRNA-mediated suppression of NICD1 links the
            presenilin/Notch1 pathway to glucotoxicity in mature pancreatic
            beta cells
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1628)
  AUTHORS   Pluta,R., Kocki,J., Ulamek-Koziol,M., Bogucka-Kocka,A.,
            Gil-Kulik,P., Januszewski,S., Jablonski,M., Petniak,A.,
            Brzozowska,J., Bogucki,J., Furmaga-Jablonska,W. and Czuczwar,S.J.
  TITLE     Alzheimer-associated presenilin 2 gene is dysregulated in rat
            medial temporal lobe cortex after complete brain ischemia due to
            cardiac arrest
  JOURNAL   Pharmacol Rep 68 (1), 155-161 (2016)
   PUBMED   26721367
  REMARK    GeneRIF: Significant dysregulation of presenilin 2 gene was found
            in neuronal cells following brain ischemia due to cardiac arrest.
REFERENCE   3  (bases 1 to 1628)
  AUTHORS   Watanabe,H., Iqbal,M., Zheng,J., Wines-Samuelson,M. and Shen,J.
  TITLE     Partial loss of presenilin impairs age-dependent neuronal survival
            in the cerebral cortex
  JOURNAL   J Neurosci 34 (48), 15912-15922 (2014)
   PUBMED   25429133
REFERENCE   4  (bases 1 to 1628)
  AUTHORS   Ezratty,E.J., Stokes,N., Chai,S., Shah,A.S., Williams,S.E. and
            Fuchs,E.
  TITLE     A role for the primary cilium in Notch signaling and epidermal
            differentiation during skin development
  JOURNAL   Cell 145 (7), 1129-1141 (2011)
   PUBMED   21703454
REFERENCE   5  (bases 1 to 1628)
  AUTHORS   Zampese,E., Fasolato,C., Kipanyula,M.J., Bortolozzi,M., Pozzan,T.
            and Pizzo,P.
  TITLE     Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria
            interactions and Ca2+ cross-talk
  JOURNAL   Proc Natl Acad Sci U S A 108 (7), 2777-2782 (2011)
   PUBMED   21285369
REFERENCE   6  (bases 1 to 1628)
  AUTHORS   Li,J., Xu,M., Zhou,H., Ma,J. and Potter,H.
  TITLE     Alzheimer presenilins in the nuclear membrane, interphase
            kinetochores, and centrosomes suggest a role in chromosome
            segregation
  JOURNAL   Cell 90 (5), 917-927 (1997)
   PUBMED   9298903
REFERENCE   7  (bases 1 to 1628)
  AUTHORS   Blanchard,V., Czech,C., Bonici,B., Clavel,N., Gohin,M., Dalet,K.,
            Revah,F., Pradier,L., Imperato,A. and Moussaoui,S.
  TITLE     Immunohistochemical analysis of presenilin 2 expression in the
            mouse brain: distribution pattern and co-localization with
            presenilin 1 protein
  JOURNAL   Brain Res 758 (1-2), 209-217 (1997)
   PUBMED   9203550
REFERENCE   8  (bases 1 to 1628)
  AUTHORS   Vito,P., Wolozin,B., Ganjei,J.K., Iwasaki,K., Lacana,E. and
            D'Adamio,L.
  TITLE     Requirement of the familial Alzheimer's disease gene PS2 for
            apoptosis. Opposing effect of ALG-3
  JOURNAL   J Biol Chem 271 (49), 31025-31028 (1996)
   PUBMED   8940094
REFERENCE   9  (bases 1 to 1628)
  AUTHORS   Wolozin,B., Iwasaki,K., Vito,P., Ganjei,J.K., Lacana,E.,
            Sunderland,T., Zhao,B., Kusiak,J.W., Wasco,W. and D'Adamio,L.
  TITLE     Participation of presenilin 2 in apoptosis: enhanced basal activity
            conferred by an Alzheimer mutation
  JOURNAL   Science 274 (5293), 1710-1713 (1996)
   PUBMED   8939861
REFERENCE   10 (bases 1 to 1628)
  AUTHORS   Clark,R.F., Hutton,M., Talbot,C., Wragg,M., Lendon,C., Busfield,F.,
            Han,S.W., Perez-Tur,J., Adams,M., Fuldner,R., Roberts,G.,
            Karran,E., Hardy,J. and Goate,A.
  TITLE     The role of presenilin 1 in the genetics of Alzheimer's disease
  JOURNAL   Cold Spring Harb Symp Quant Biol 61, 551-558 (1996)
   PUBMED   9246481
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078805.1.
            
            On Jun 10, 2007 this sequence version replaced NM_031087.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078805.1, FQ219614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..1628
                     /gene="Psen2"
                     /note="presenilin 2"
                     /db_xref="GeneID:81751"
                     /db_xref="RGD:621060"
     exon            1..94
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            95..238
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1444
                     /gene="Psen2"
                     /note="PS-2"
                     /codon_start=1
                     /product="presenilin-2"
                     /protein_id="NP_112349.2"
                     /db_xref="GeneID:81751"
                     /db_xref="RGD:621060"
                     /translation="MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENT
                     AQWRSQENEDDCEEDPDHYACSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVV
                     VATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLY
                     KYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVFKTYNVAMDYPTLFLAVWNFGAVGMVC
                     IHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRM
                     LVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEP
                     SYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWSTTLACF
                     IAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI"
     exon            239..453
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..595
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..663
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..884
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..983
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1067
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1169
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1288
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1594
                     /gene="Psen2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgactgaca gctgcgtcaa gctcctccca ccgtgaggcg cctgtctgat gagctgagag
       61 ccagaataaa ctctggaacg gtgttgtcgc tgagaccatg ctcacattca tggcctctga
      121 tagcgaggaa gaggtgtgcg atgagcggac gtccttgatg tcagccgaga gccctacatc
      181 acgttcctgc caggacagca ggccaggccc agaggatgga gagaacactg cccagtggag
      241 gagccaggag aacgaggacg actgtgagga ggacccggac cactatgcct gcagtggggt
      301 tcctgggcga ccatcgggcc tggaggagga gctgaccctc aagtatgggg cgaagcacgt
      361 gatcatgctg ttcgtgcctg tcacgctgtg catgattgtg gtggtggcca ccatcaagtc
      421 cgtgcgtttc tacacggaga agaacgggca gctcatctac acgcccttca ccgaggacac
      481 accctctgtg ggccagcggc tcctcaactc cgtgctgaac actctgatca tgatcagcgt
      541 cattgtggtc atgactatct tcctagtggt actctacaaa tatcgctgtt acaagttcat
      601 ccatggctgg ctgatcatgt cctccctgat gctcctcttc ttgttcacct acatctacct
      661 cggggaagtg ttcaagacct acaatgtggc catggactac cccacactgt tcctggctgt
      721 ctggaacttc ggggcagtgg gcatggtgtg catccactgg aagggtcccc tggtgctcca
      781 gcaggcttac ctcattgtga tcagcgcact catggccctg gtgttcatca agtacctgcc
      841 ggagtggtcc gcttgggtca tcttgggcgc catctctgtg tacgatctcg tggctgtgct
      901 gtgccccaaa gggccactga ggatgctggt ggaaactgcc caggaaagaa acgagcccat
      961 atttcctgcc ctcatatact catctgccat ggtgtggacg gtaggcatgg cgaagctgga
     1021 cccctcctct cagggagcac tgcagctccc ttacgatcca gagatggaag aagactccta
     1081 tgacagtttt ggggaaccct cataccctga agccttcgaa gctccccagc ctggctaccc
     1141 aggggaagag ccggaggagg aggaggaaag gggtgtaaag cttggtctgg gagacttcat
     1201 cttctacagc gttctggtgg gcaaggcagc agccacaggc aacggagact ggagcacgac
     1261 gctggcctgc tttatcgcca tcctcattgg cttgtgtctc accctcctgc tgctcgccgt
     1321 gttcaagaag gccctgcccg ccctccccat ctccatcacc ttcgggctca tcttttactt
     1381 ctccacagac aacctggtgc gtcctttcat ggacacgttg gcctcccacc agctctacat
     1441 ctgacagaag agctgcggct ctgagagctg taggacgctt cgccgaatgc aggtgtatag
     1501 ttttacactc tagtgccata tatttttttt taaaaaaacc tttctttcct tacaaaagaa
     1561 aaaaaaagaa taaaaaagtg ttgtgtttac ttcgaaaaaa aaaaaaaaaa aaaaaaaaaa
     1621 aaaaaaaa
//
