LOCUS       NM_019163               6130 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus presenilin 1 (Psen1), mRNA.
ACCESSION   NM_019163 XM_006240321
VERSION     NM_019163.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6130)
  AUTHORS   Xin,X., Duan,L., Yang,H., Yu,H., Bao,Y., Jia,D., Wu,N. and Qiao,Y.
  TITLE     miR-141-3p regulates saturated fatty acid-induced cardiomyocyte
            apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1
  JOURNAL   Environ Toxicol 37 (4), 741-753 (2022)
   PUBMED   34897970
  REMARK    GeneRIF: miR-141-3p regulates saturated fatty acid-induced
            cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via
            targeting PSEN1.
REFERENCE   2  (bases 1 to 6130)
  AUTHORS   Tambini,M.D. and D'Adamio,L.
  TITLE     Knock-in rats with homozygous PSEN1L435F Alzheimer mutation are
            viable and show selective gamma-secretase activity loss causing low
            Abeta40/42 and high Abeta43
  JOURNAL   J Biol Chem 295 (21), 7442-7451 (2020)
   PUBMED   32265300
  REMARK    GeneRIF: Knock-in rats with homozygous PSEN1(L435F) Alzheimer
            mutation are viable and show selective gamma-secretase activity
            loss causing low Abeta40/42 and high Abeta43.
REFERENCE   3  (bases 1 to 6130)
  AUTHORS   Stenovec,M., Trkov Bobnar,S., Smolic,T., Kreft,M., Parpura,V. and
            Zorec,R.
  TITLE     Presenilin PS1E9 disrupts mobility of secretory organelles in rat
            astrocytes
  JOURNAL   Acta Physiol (Oxf) 223 (2), e13046 (2018)
   PUBMED   29392878
  REMARK    GeneRIF: results revealed a common, vesicle-type indiscriminate
            trafficking defect in PS1DeltaE9 astrocytes
REFERENCE   4  (bases 1 to 6130)
  AUTHORS   Klakotskaia,D., Agca,C., Richardson,R.A., Stopa,E.G.,
            Schachtman,T.R. and Agca,Y.
  TITLE     Memory deficiency, cerebral amyloid angiopathy, and amyloid-beta
            plaques in APP+PS1 double transgenic rat model of Alzheimer's
            disease
  JOURNAL   PLoS One 13 (4), e0195469 (2018)
   PUBMED   29641600
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6130)
  AUTHORS   Holland,R., McIntosh,A.L., Finucane,O.M., Mela,V., Rubio-Araiz,A.,
            Timmons,G., McCarthy,S.A., Gun'ko,Y.K. and Lynch,M.A.
  TITLE     Inflammatory microglia are glycolytic and iron retentive and typify
            the microglia in APP/PS1 mice
  JOURNAL   Brain Behav Immun 68, 183-196 (2018)
   PUBMED   29061364
REFERENCE   6  (bases 1 to 6130)
  AUTHORS   Taniguchi,T., Hashimoto,T., Taniguchi,R., Shimada,K., Kawamata,T.,
            Yasuda,M., Nakai,M., Terashima,A., Koizumi,T., Maeda,K. and
            Tanaka,C.
  TITLE     Cloning of the cDNA encoding rat Presenilin-1
  JOURNAL   Gene 186 (1), 73-75 (1997)
   PUBMED   9047347
REFERENCE   7  (bases 1 to 6130)
  AUTHORS   Lee,M.K., Slunt,H.H., Martin,L.J., Thinakaran,G., Kim,G.,
            Gandy,S.E., Seeger,M., Koo,E., Price,D.L. and Sisodia,S.S.
  TITLE     Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine
            tissues
  JOURNAL   J Neurosci 16 (23), 7513-7525 (1996)
   PUBMED   8922407
REFERENCE   8  (bases 1 to 6130)
  AUTHORS   Thinakaran,G., Borchelt,D.R., Lee,M.K., Slunt,H.H., Spitzer,L.,
            Kim,G., Ratovitsky,T., Davenport,F., Nordstedt,C., Seeger,M.,
            Hardy,J., Levey,A.I., Gandy,S.E., Jenkins,N.A., Copeland,N.G.,
            Price,D.L. and Sisodia,S.S.
  TITLE     Endoproteolysis of presenilin 1 and accumulation of processed
            derivatives in vivo
  JOURNAL   Neuron 17 (1), 181-190 (1996)
   PUBMED   8755489
REFERENCE   9  (bases 1 to 6130)
  AUTHORS   Takahashi,H., Murayama,M., Takashima,A., Mercken,M., Nakazato,Y.,
            Noguchi,K. and Imahori,K.
  TITLE     Molecular cloning and expression of the rat homologue of
            presenilin-1
  JOURNAL   Neurosci Lett 206 (2-3), 113-116 (1996)
   PUBMED   8710164
REFERENCE   10 (bases 1 to 6130)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Sep 19, 2022 this sequence version replaced
            XM_006240321.4, NM_019163.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.18776.1,
                                           SRR26360194.511930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000006.1  109054160-109054276
            118-189             JAXUCZ010000006.1  109065114-109065185
            190-326             JAXUCZ010000006.1  109065278-109065414
            327-580             JAXUCZ010000006.1  109080795-109081048
            581-722             JAXUCZ010000006.1  109082968-109083109
            723-790             JAXUCZ010000006.1  109090650-109090717
            791-1011            JAXUCZ010000006.1  109092484-109092704
            1012-1110           JAXUCZ010000006.1  109096088-109096186
            1111-1197           JAXUCZ010000006.1  109096745-109096831
            1198-1374           JAXUCZ010000006.1  109098634-109098810
            1375-1493           JAXUCZ010000006.1  109099902-109100020
            1494-6130           JAXUCZ010000006.1  109101555-109106191
FEATURES             Location/Qualifiers
     source          1..6130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..6130
                     /gene="Psen1"
                     /note="presenilin 1"
                     /db_xref="GeneID:29192"
                     /db_xref="RGD:3425"
     exon            1..117
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..189
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..326
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1649
                     /gene="Psen1"
                     /EC_number="3.4.23.-"
                     /note="PS-1"
                     /codon_start=1
                     /product="presenilin-1"
                     /protein_id="NP_062036.2"
                     /db_xref="GeneID:29192"
                     /db_xref="RGD:3425"
                     /translation="MTEIPAPLSYFQNAQMSEDSHSSSVRSQNDNQERQQHHDRQRLD
                     NPESISNGRPQSNFTRQVIEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKS
                     VSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYK
                     VIHAWLIVSSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMIAIHWKGP
                     LRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQ
                     ERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVPKNPKYSTQGTEREETQDTGTGSDD
                     GGFSEEWEAQRDSHLGPHRSTPESRAAVQELSGSILTSEDPEERGVKLGLGDFIFYSV
                     LVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFAT
                     DYLVQPFMDQLAFHQFYI"
     exon            327..580
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..722
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..790
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1011
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1110
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1197
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1374
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1493
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..6130
                     /gene="Psen1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcggggc ctaggacgac ctgctcagtg ggccgcgagt attcgtcgga aacaaaacag
       61 cggcagctga ggcggaaacc tagctgcgag ccggctgccc gggcgcggag agcgaaggaa
      121 ccaatacaag acagcagccc ttcgaggtcc ttaggcagct tggcctggag gagaacacat
      181 gagagaaaga atccccagag gctttgtttt ctttgaaaag gtatttctgt acagttgctc
      241 caatgacaga gatacctgca cctttgtcct acttccagaa tgcacagatg tctgaggaca
      301 gccactccag cagcgtccgt agccagaatg acaatcaaga acggcagcag catcatgaca
      361 gacagagact tgacaaccct gagtcgatat ctaatggccg accccagagt aactttacca
      421 ggcaggtgat agagcaagat gaggaggaag acgaagagct gacattgaaa tatggagcca
      481 agcacgtcat catgctcttt gttcctgtga ccctctgcat ggtcgttgtg gtggccacca
      541 tcaagtcagt cagcttctac acccggaagg atgggcagct aatctatacc ccattcacag
      601 aagacaccga gactgtaggc cagagagccc tgcactcgat cttgaatgcc gccatcatga
      661 tcagtgtcat cgtcgttatg accatcctcc tggtggtcct gtataagtac aggtgctaca
      721 aggtcatcca tgcctggctt attgtttcat ctctgttgtt gctgttcttt ttttcattca
      781 tttacttagg ggaagtattc aagacctaca atgtcgccgt ggactatatt acggttgcac
      841 tcctgatctg gaattttggt gtggtcggga tgattgccat tcactggaaa ggcccactcc
      901 gactgcagca ggcgtatctc attatgatca gtgccctcat ggccctggta tttatcaagt
      961 acctccctga atggaccgca tggctcatct tggctgtgat ttcagtatat gatttggtgg
     1021 ctgttctgtg ccccaaaggt ccacttcgta tgctggtcga aacagctcag gaaagaaatg
     1081 agactctctt tccagctctt atctattcct caaccatggt gtggttggtg aatatggctg
     1141 aaggagaccc agaagcccaa aggagggtac ccaaaaaccc caagtatagc acacaaggaa
     1201 cagagaggga agagacacag gacactggca ctgggagcga tgatggtggc ttcagtgagg
     1261 agtgggaggc ccaaagagac agtcacctgg ggcctcatcg ctccactcct gagtcaagag
     1321 ctgctgtcca ggaactttct gggagcatcc tcactagtga agacccggag gaaagaggag
     1381 taaagcttgg gctgggagat ttcattttct acagtgttct ggttggtaag gcctcagcga
     1441 ccgccagtgg ggactggaac acaaccatag cctgctttgt agccatattg atcggcctgt
     1501 gccttacgtt actcctgctc gccattttca agaaagcgtt gccggccctt cccatctcca
     1561 tcaccttcgg gctcattttc tactttgcca cggattatct cgtgcagccc ttcatggacc
     1621 aacttgcatt ccatcaattt tatatctagc atttccacac tcagaccatg gatgattctt
     1681 ctttgattat cagaaaaaca aaaacataaa gcaaacctgg gcagggcatg gatgattgtc
     1741 ctgtgtcctc agcgaacaaa gtcacgactc cagcttggct ttgaccgctt ccttccggtt
     1801 tccccagcca cctgcactac tggacttggg aaggaagtaa ctacagaaaa cggtttccaa
     1861 cacttgtcat tgcatcggac gatgtcactc agtgaagaaa ctaccaggct gagagacaag
     1921 gactaagtat gctggccgag aagctgctgg gctctaccag cactttgacc cttggacatg
     1981 gagattgacc agcactggga actctcaaga ggttaaatga agtgaagtga gccaagcaga
     2041 gctgccgtct tccatgccat gttggaaata aaacatgccc tagctgaatc ctgcactgtc
     2101 cagggggttc tgtgcagagg tggcactgga cccaggtccc cgcagtctcc tttgctgccc
     2161 actcgtaagt ttaaataagg atgccaccct acacaagccc caacccctgt cacatcagtg
     2221 actttgacca tttttgctct caagcactga cactattatc tgtggttgcc atttcttccc
     2281 aaggccagtc tggatgaatt tggggtggct ttatcctgag agttgtaacc tcaggttcca
     2341 aagtctgtac ttctcttgaa atgatggaac tatttctcaa cagtcccctg tcatccttaa
     2401 gtaacttctg ggttttccac aaattcctca tttttagaca tactttaggt ttacttttgg
     2461 cctggatgct tcctctccct gtctctctct tgtcccacag cagttccctc tgacagcaga
     2521 caaggcagct ctgggaggga gccagtggcc ctgatagccc agggggtacc tcatgtgatg
     2581 caaatactcc gtgtcaatca agcagtgcag tgagccgtgc tgctgtgctg ccacagctcc
     2641 ctggacagca aacaggatgt gtgcccaaag aattaaagtg acgggtggct ggtgaagcgc
     2701 tctctgtcct gactgttctt ttgtcaccgc aatccactgt caaggacaga atttaaaact
     2761 aggggctggg ggacagctcc aaatacaatg cctgtcttgc cctcggccca gtccccagca
     2821 ttgggggaaa aaaaaataaa accacaagat ttaaattaat gtctagtgct ggtagttggt
     2881 cagttcatga atcagttgtg tctaaaaaac caagggtttg gagaaaagtt gtttgttggt
     2941 tagccgtgaa agaacctaga cgcaggactt aagccagtcg ccaagaggaa agatgggctt
     3001 cccacagcca tgggacagag tgagttagct acacaggcac gtgtgaggga cgaggctctg
     3061 cttcctcagg agccgtagaa gagtggcctc actctcgctt ctggtctgtc tgcctcttct
     3121 ctcatctcag tgctccattg tgtggtgcga gcagtggcca tgtgctgagt ttacagtgag
     3181 catgggtgct gtggacctgt caggctgagc agtagtccct tgtacctgtg gcagccacct
     3241 cagccaggac accagctggt aagacttgag aaactagtgt ggctcaacca aggacgctgg
     3301 ctttctctcc cagcctgtcc taggaaccac ttgagggtta ggatacttat tttgggtcac
     3361 acagttgtgc tgttgatcta gcccgggggc tttgggcatg ctagcaagtg aggcctggag
     3421 tgatcctagg aaggatttga ccttaggagt ctagtagtcc cctctgtggt gaggcggaga
     3481 caggcgggtc cctgggctta ctggccagtc agcccagccc catccaggtt taggccaatg
     3541 aagagcccta tgtcacagag caaggtggac agctcctgag gaacgacaca cggaggagct
     3601 gagggcgagc tttgggagag cttggtacat gcaacatcct caaggccctg cgctcatttc
     3661 ccaggctgtg tttaaagaat atgaacccag acagaatcat ctcggctgaa gaagagagcc
     3721 ttgcagggag gagaggggct tgtgctagaa ggttctgcat ttttattatc aagcatatgt
     3781 gaggtcagcc ctgtggtgca tgggttctaa ggagcaaacc aggtcactag gtacgctgtg
     3841 ggcaagagcc gctaaccagc ctggccacct cactagcccc ttttcccaag accttgccgc
     3901 tctcacacag acagcagatg ggaagtttta gtttgaggca cttttgccaa tctcaggtag
     3961 agcagtgtgt gtaagggtct caagtgtgac gtgtgtttag taacaagaag atatgggctg
     4021 tgattgtgtg caggtgttcc agtccaggag aggagtggcc acaagccagg caacatctgg
     4081 aataaagcca ctgcccccac ctgcttggtg ggaagaaatg tagtagcttt agggctttgg
     4141 tccaatgcct acaggatatg gggcatttat gggcagtgcc agctgcaatc gaggggctgg
     4201 agaggaaggg cgcttcttcc tggttttgat tctgctgggt taaagggatc ctaggttcac
     4261 agctttcaca ccggatgact aaatttctcc aagaggaaaa gagagagcaa gcaagcaaag
     4321 gacagcagcc aaatgtgatc tgttagagaa agtgtgcaaa agacaagagc caaaagaaat
     4381 ctattgactt caccacaaaa ggagcaaaga tctgtggttt ttgcttgcaa acttcgcttg
     4441 aaagtttagt gtcttttgtg atagatgccc aagtgaaggg tacatttact gcttgttctg
     4501 tctgtggttt cacgcacatt agatagggtc tcccgtgtag cccaggctga actcaattta
     4561 atggtccttc tgccttcacc ttacaagtgc tgggcgtcac aagacatgga ccatcatgcc
     4621 aagttacatc tatgtacata catacacata tgcatatata tattatattt ctgcacagag
     4681 catgtgccta catgaggtca gaggacagtt aacagcaagt ggttctctcc tcccatcatg
     4741 tgagttccag gaactgaact caggtcctca ggcttggagg tgcatgcttc tacccactga
     4801 gccatctggc tgggcctatg gatattcctg accctaactt gttgaatgtg aaattgatgc
     4861 taactgccaa ataaggtctt ccaagatcgg gcttctaatg ggaggctctg tctctgaccc
     4921 tcagagccag gctttgtgat ctaaccctgg aagaaaagct gaggggttta ttcagtctcc
     4981 tgagtgattg gcttggtgct gcagtctcac ctgccctctt cctacctttt tccctccctc
     5041 ccctcccccc tttcccttct gtttcttgtt ctttcctctt ctcctttctg aaagaaaccc
     5101 caggctcttg ccagacccac tctagagcag aggatgatct tgaacttctg tccttctact
     5161 tccacacccc aagttctgag atcactcaca tgcacccctg tgcccagttt attctatgct
     5221 ggggatcaaa cctggggctg tgtgcatgct agctaagcac tctaccatct gagctacacc
     5281 ccctggcccc acccatcctg acttctctca actcctgagg cttacagagt gagtgctgtt
     5341 aaggggacct cattccttca gaagcccccc tagttaagtg agctcttgag tggtctatgc
     5401 agatcagcct gggccacctc tcctcactcc ctgtgggtct ttaatgctga atttgaagac
     5461 aatttggaaa ctggacattt gcattcaccc ttgggatgga aataatgcca tttcttgatg
     5521 ataagttaga gtcttaagag cagcccgggg gtcttgtgtc tttctccaaa cctgggcagt
     5581 tctacaaacg cacaccaaag gaaaggcttt gcagcctttc ttgatggtgc catccagata
     5641 cctgtgggct gtcccatctc agggtcttct gcacctcatt ggtctactag gctgctagaa
     5701 acccctactc tgcatattgc aaagcacagc ctggtgctga aatgtaccct ttcttgactg
     5761 tcaaagccat ttaatgggcg tttggaggag caatgtgcct ttgaggatgc aagtgtcccc
     5821 ttgggcccta gagtatagag cttacacatg tctccctagc aggaaggatt tccccgaaag
     5881 cacttctatt caaatacaga cttgttgaag gccactgcag agtggcagtg ccagggtgag
     5941 aacttctgag gggttcttta ctctcacatg gtcacggcct ggcttctacc atgggtacta
     6001 ctttgtacat aacactgtga atgcaacttt ttaaataaat acctttcaaa ctcttgggaa
     6061 gctataattt tgatagatga ttgcagattt tcctgtattt gtcaaatgaa taaagaatgc
     6121 atgagcctaa
//
