LOCUS       NM_134370               4007 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pleckstrin and Sec7 domain containing (Psd),
            mRNA.
ACCESSION   NM_134370 XM_346586 XM_347359
VERSION     NM_134370.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4007)
  AUTHORS   Fukaya,M., Ibuchi,K., Sugawara,T., Itakura,M., Ito,A.,
            Shiroshima,T., Hara,Y., Okamoto,H., Luton,F. and Sakagami,H.
  TITLE     EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA
            Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
  JOURNAL   Traffic 25 (5), e12936 (2024)
   PUBMED   38725127
  REMARK    GeneRIF: EFA6A, an Exchange Factor for Arf6, Regulates
            NGF-Dependent TrkA Recycling From Early Endosomes and Neurite
            Outgrowth in PC12 Cells.
REFERENCE   2  (bases 1 to 4007)
  AUTHORS   Eva,R., Koseki,H., Kanamarlapudi,V. and Fawcett,J.W.
  TITLE     EFA6 regulates selective polarised transport and axon regeneration
            from the axon initial segment
  JOURNAL   J Cell Sci 130 (21), 3663-3675 (2017)
   PUBMED   28935671
  REMARK    GeneRIF: EFA6 regulates selective polarized transport and axon
            regeneration from the axon initial segment.
REFERENCE   3  (bases 1 to 4007)
  AUTHORS   Fukaya,M., Fukushima,D., Hara,Y. and Sakagami,H.
  TITLE     EFA6A, a guanine nucleotide exchange factor for Arf6, interacts
            with sorting nexin-1 and regulates neurite outgrowth
  JOURNAL   J Neurochem 129 (1), 21-36 (2014)
   PUBMED   24261326
REFERENCE   4  (bases 1 to 4007)
  AUTHORS   Ueda,T., Hanai,A., Takei,T., Kubo,K., Ohgi,M., Sakagami,H.,
            Takahashi,S., Shin,H.W. and Nakayama,K.
  TITLE     EFA6 activates Arf6 and participates in its targeting to the
            Flemming body during cytokinesis
  JOURNAL   FEBS Lett 587 (11), 1617-1623 (2013)
   PUBMED   23603394
REFERENCE   5  (bases 1 to 4007)
  AUTHORS   Sironi,C., Teesalu,T., Muggia,A., Fontana,G., Marino,F.,
            Savaresi,S. and Talarico,D.
  TITLE     EFA6A encodes two isoforms with distinct biological activities in
            neuronal cells
  JOURNAL   J Cell Sci 122 (Pt 12), 2108-2118 (2009)
   PUBMED   19494129
  REMARK    GeneRIF: EFA6A could participate in neuronal morphogenesis through
            the regulated expression of two functionally distinct isoforms.
REFERENCE   6  (bases 1 to 4007)
  AUTHORS   Choi,S., Ko,J., Lee,J.R., Lee,H.W., Kim,K., Chung,H.S., Kim,H. and
            Kim,E.
  TITLE     ARF6 and EFA6A regulate the development and maintenance of
            dendritic spines
  JOURNAL   J Neurosci 26 (18), 4811-4819 (2006)
   PUBMED   16672654
REFERENCE   7  (bases 1 to 4007)
  AUTHORS   Sakagami,H., Matsuya,S., Nishimura,H., Suzuki,R. and Kondo,H.
  TITLE     Somatodendritic localization of the mRNA for EFA6A, a guanine
            nucleotide exchange protein for ARF6, in rat hippocampus and its
            involvement in dendritic formation
  JOURNAL   Eur J Neurosci 19 (4), 863-870 (2004)
   PUBMED   15009133
  REMARK    GeneRIF: There is definitive evidence for somatodendritic
            localization of EFA6 mRNA in both cultured and in vivo hippocampal
            neurons: during postnatal development, it is dramatically
            increased.
REFERENCE   8  (bases 1 to 4007)
  AUTHORS   Suzuki,I., Owada,Y., Suzuki,R., Yoshimoto,T. and Kondo,H.
  TITLE     Localization of mRNAs for subfamily of guanine nucleotide-exchange
            proteins (GEP) for ARFs (ADP-ribosylation factors) in the brain of
            developing and mature rats under normal and postaxotomy conditions
  JOURNAL   Brain Res Mol Brain Res 98 (1-2), 41-50 (2002)
   PUBMED   11834294
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On Oct 22, 2008 this sequence version replaced NM_134370.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4007
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /note="pleckstrin and Sec7 domain containing"
                     /db_xref="GeneID:171381"
                     /db_xref="RGD:620297"
     exon            1..153
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            154..209
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            210..946
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..3364
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /note="pleckstrin homology and SEC7 domain-containing
                     protein 1; exchange factor for ARF6 A; exchange factor for
                     ADP-ribosylation factor guanine nucleotide factor 6"
                     /codon_start=1
                     /product="PH and SEC7 domain-containing protein 1"
                     /protein_id="NP_599197.2"
                     /db_xref="GeneID:171381"
                     /db_xref="RGD:620297"
                     /translation="MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTG
                     SLIRRVVGPGPRGRDLGRVTAPCTPLRAPPSPHIAPSPWGPSSPTGKPPPGAQSSVVI
                     FRFVEKASVRPLNGLPASGGLSRSWDLGGISPSRPTPALGPGCNRKLRLEASTSDPLP
                     AGGGSVLPGSRDPSRGPLIPPQIGADGLYSSLPNGLGGTPEHLVMHFRGPADTGFLNQ
                     GDTWSSREVSSHAQRIARAKWEFFYGSLDPPSSGAKPPEQALPSHGVGSKQGSGVAVG
                     RAAKYSETDLDKVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTTQPPASRPS
                     PCPGPSSSLGSGNGDDEAGGEEDVDDEVFEASEGARPGDHMPHSGLLKSPVPFLPGTS
                     PSADGPDSFSCMFEAIMESHRAKGTSYSSLASLEALASPGPTQSPFFTFEMPPQPPAP
                     RPDPPAPAPLAPLEPDSGTSSVADGPWTQRREVEESDAGATLAPRKELPSPSHSEDSL
                     GLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYR
                     LDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQER
                     ERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLE
                     GLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRVSGGSGS
                     SSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQK
                     EEYQPGKALSEAELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQM
                     QSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMA
                     SELREHRAAHLGKKARGKEAEEQRQKETYLEFEKSRYGTYAALLRVKMKAASEELDAI
                     EAALAQAGSTEEGCPPPHSSPSLQPNPTSQPRAQRPGSEARAGAGSTRPKP"
     exon            947..1046
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1401
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1842
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2037
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2118
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2231
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2290
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2380
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2424
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2615
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2686
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2844
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2989
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3133
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..4007
                     /gene="Psd"
                     /gene_synonym="EFA6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgtggggt ctggagcagg acaggcgtat gcagctggac ccttcgtgtg gttcaggaga
       61 tgatggacga gagagaactg aacacgagtg gggtggggca tatgagggtt tagggaacag
      121 aaccagggct ttctacatcc tccctttcct ctgctgagcg gggcccagcc tctctgcctc
      181 tcttcgattc cagctcctga cgagcagcgg cctgtctgaa gagcatgcag cccccttact
      241 ccctgcctgg cctcgccatc cctgcccccc cagcctgacc cccggctcca gcatggccca
      301 gggtgccatg cggttctgct cagaaggcga ctgtgccatc tccccaccac gatgccctcg
      361 tcgctggctc ccggaaggcc cagtgcccca aagtccccca gccagcatgt atggcagcac
      421 aggatcccta atacgacgag tggtgggccc aggtcctcga ggccgggatc tgggacgtgt
      481 gacagcacct tgtacccctc tgcgagcccc tccctcaccc catatagctc cctcaccctg
      541 gggaccctct tcacccactg ggaagccccc accaggggca cagagttctg tggtcatctt
      601 ccgtttcgtg gagaaggcca gtgtgaggcc actgaatggc ctacctgctt ctggaggcct
      661 gagtcggagc tgggacctgg gtgggatttc tccctccagg cccaccccag cccttggacc
      721 tggctgcaac cggaagttgc ggctagaagc gtccacatca gacccactcc cagccggagg
      781 aggctccgtt cttcctggca gcagggaccc ctcacgtggg ccattgatcc caccccagat
      841 tggggcagat ggcctttact cctctctccc caatgggctg ggggggaccc ctgagcactt
      901 ggtcatgcac ttccgaggac ctgcagacac cggatttcta aaccaggggg acacctggtc
      961 ctcccgggaa gtctcctctc atgcccagag aatcgctcga gccaagtggg aattcttcta
     1021 tggctccttg gaccccccca gctcaggtgc taagccccca gagcaggccc tcccatcaca
     1081 tggggtgggc tccaagcaag gctctggggt agctgtgggg cgagcagcca agtactccga
     1141 gacagacctg gacaaggtac ccctgaggtg ctaccgagag actgacattg acgaggtgct
     1201 ggctgagcgg gaggaggctg actccgccat tgagagtcag cccagctctg agggcccccc
     1261 tggcactacc caaccacctg cctcacgacc cagcccatgc cctggtcctt cttccagtct
     1321 gggcagtggt aacggagatg atgaggcagg tggtgaagag gacgtggatg atgaggtgtt
     1381 tgaggcctca gagggggccc ggccagggga ccacatgcct cactctgggc tcctcaagtc
     1441 accagtcccc tttctaccgg ggaccagccc ctcagcggat gggcctgact ctttcagttg
     1501 tatgtttgaa gccatcatgg agtcgcaccg ggccaagggc acctcctata gtagccttgc
     1561 ctccctggaa gctctggcct cacctggccc aacccagagt cccttcttca cctttgagat
     1621 gcctccccaa cccccagctc cccggcctga cccacctgca cctgccccac ttgcccctct
     1681 tgaaccggat tctggtacca gctctgttgc tgatggtcct tggacccaaa ggagagaggt
     1741 agaagagtca gatgctgggg ctacgctggc cccaaggaaa gagcttccta gtccctccca
     1801 ctctgaggac agccttgggc tgggggcagc acccctgggc agtgaaccgc ccctgagcca
     1861 actggtgtcc gactcagact cagagctgga cagcacagag cggctggccc tgggaagcac
     1921 agacaccttg tccaatggac agaaagcaga tctggaggct gcacagcgcc tagccaagag
     1981 gctataccga cttgatggct tcaggaaggc cgacgtagcc cggcatctgg gcaagaacaa
     2041 tgacttcagc aaattggtgg ctggcgagta tctcaagttt tttgtcttca cgggcatgac
     2101 cctggatcaa gctctcaggg tgtttctaaa ggagctggct ttaatgggtg agacccagga
     2161 gcgggagcgt gtactggccc acttctccca gcgatatttc cagtgtaatc ctgaagccct
     2221 gtcctcagag gacggcgctc acacgctgac ctgtgctctc atgctcctca acacggacct
     2281 ccacggccac aacattggga agcgaatgac ctgtggggac ttcatcggaa acctggaggg
     2341 cctcaatgat ggcggcgact tccccaggga gctgctcaag gccttgtaca gctccatcaa
     2401 gaatgaaaag ttgcaatggg ccatagacga ggaggaactt cggcgatctc tgtccgagtt
     2461 ggccgaccct aaccccaagg tcatcaagag ggtcagcgga ggcagcggca gcagctccag
     2521 ccccttcctg gacctgactc ccgagcctgg ggcagctgtc tacaagcacg gggccctggt
     2581 gcgaaaggtg cacgcagacc ctgactgcag gaagacacct cgtggcaagc ggggctggaa
     2641 gagcttccac gggatcctca agggcatgat cctctacctg cagaaggagg agtaccagcc
     2701 cgggaaggct ctttccgagg cagagctgaa gaacgccatt agcattcacc acgctctggc
     2761 cacccgcgcc agcgactaca gcaagagacc acacgtcttc tacctgcgca cagccgactg
     2821 gagggtcttc ctcttccagg ccccgagcct ggagcaaatg cagtcctgga ttactcgcat
     2881 caatgtggtg gctgccatgt tttctgcacc ccccttccca gctgctgtca gttcccagaa
     2941 gaaattcagc cgtcctctgc tgcccagcgc tgccacccgc ctctcccagg aggagcaggt
     3001 gaggactcac gaggccaagc tgaaggccat ggcaagcgag cttcgagagc accgggcagc
     3061 acatctgggg aagaaggccc gaggcaagga ggctgaggag cagaggcaga aggagaccta
     3121 cctggagttt gagaaatccc gctatggcac ctacgcggcg ctgcttcgag tcaagatgaa
     3181 ggccgccagc gaggagctgg atgccataga ggcagcactg gcccaggctg ggagcacgga
     3241 ggaaggatgc cctccgcctc actccagtcc ttccctgcag cccaacccca ccagccagcc
     3301 ccgggctcag cgtcctggct cagaagcccg ggccggggca ggcagtacaa ggccaaagcc
     3361 ctgagcaggg agtaggagca atgggggcag tgcctgctgg gcacctgcat gatgacatgg
     3421 ccccgcctga gctcagctag cctcaggcca gccacggggg cctcctggtc cagggcccga
     3481 ccgcgccgga cgcggtgtcc ggggcagggc agggctgagc cgggcctcag agcctaggct
     3541 gagggcctct cagagacccc ctttttgtga taatgttttg cactttttcg tacaggaagg
     3601 gtgggtaggg tgggaggggc ccacgcccct aatttttgat gggggtttcc tttccttttc
     3661 tttctttttt ctttttcttt tctcttcttt ttcttttctt tttttttctt ttttttgtgg
     3721 gtggggaggc ctgataaagt ttctgctttc tgctgagacc cccccaccct tacaccagca
     3781 atacccctcc atcctggggc ctggctcaga cagaggccag gagttggggc tgagctggtc
     3841 cccctctttc tccccaaggg ctcacctctc tctttgcaga gacagaggaa aggcgtccat
     3901 gctgaggccc catccacagg ctggggtggc acggcctgct tccctcctct ggtgggccct
     3961 gccctttgta tagccttcac cctcattaaa actgctctga attgctg
//
