LOCUS       NP_942033                370 aa            linear   ROD 03-APR-2024
DEFINITION  phosphoserine aminotransferase [Rattus norvegicus].
ACCESSION   NP_942033 XP_215179
VERSION     NP_942033.2
DBSOURCE    REFSEQ: accession NM_198738.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 370)
  AUTHORS   Jia,L., Li,D., Wang,Y.N., Zhang,D. and Xu,X.
  TITLE     PSAT1 positively regulates the osteogenic lineage differentiation
            of periodontal ligament stem cells through the
            ATF4/PSAT1/Akt/GSK3beta/beta-catenin axis
  JOURNAL   J Transl Med 21 (1), 70 (2023)
   PUBMED   36732787
  REMARK    GeneRIF: PSAT1 positively regulates the osteogenic lineage
            differentiation of periodontal ligament stem cells through the
            ATF4/PSAT1/Akt/GSK3beta/beta-catenin axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 370)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (residues 1 to 370)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (residues 1 to 370)
  AUTHORS   Basurko,M.J., Marche,M., Darriet,M. and Cassaigne,A.
  TITLE     Phosphoserine aminotransferase, the second step-catalyzing enzyme
            for serine biosynthesis
  JOURNAL   IUBMB Life 48 (5), 525-529 (1999)
   PUBMED   10637769
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079352.1.
            
            On Mar 27, 2005 this sequence version replaced NP_942033.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079352.1, AY239016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..370
                     /product="phosphoserine aminotransferase"
                     /EC_number="2.6.1.52"
                     /calculated_mol_wt=40496
     Region          8..366
                     /region_name="PSAT_like"
                     /note="Phosphoserine aminotransferase (PSAT) family. This
                     family belongs to pyridoxal phosphate (PLP)-dependent
                     aspartate aminotransferase superfamily (fold I). The major
                     group in this CD corresponds to phosphoserine
                     aminotransferase (PSAT). PSAT is active as...; cd00611"
                     /db_xref="CDD:99736"
     Site            order(9,14..15,17,76..77,80,114,117..118,205,241..243)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:99736"
     Site            order(12,79..80,107,156,176,199..200,335)
                     /site_type="active"
                     /note="substrate-cofactor binding pocket [active]"
                     /db_xref="CDD:99736"
     Site            order(78..80,107,156,176,178,199..200)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99736"
     Site            200
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99736"
     CDS             1..370
                     /gene="Psat1"
                     /gene_synonym="Psa1"
                     /coded_by="NM_198738.2:18..1130"
                     /db_xref="GeneID:293820"
                     /db_xref="RGD:735170"
ORIGIN      
        1 meatkqvvnf gpgpaklpys vlleiqkqll dykglgisvl emshrspdfa kiisntenlv
       61 rellvvpnny kvifvqgggt gqfsavplnl iglkagrcad yvvtgawsak aaeeakkfgt
      121 vnivhpklgs ytkipdpstw nlnpdasyvy fcanetvhgv efdfipdvkg avlvcdmssn
      181 flsrpvdvsk fgvifagaqk nvgsagvtvv ivrddllgfa lrecpsvldy kvqagnnsly
      241 ntppcfsiyv mdmvlewikn nggaaamekl ssvksqmiye iidnsqgfyv cpverqnrsr
      301 mnipfrigns kgdealekrf ldkavelnmi slkghrsvgg iraslynavt tedveklaaf
      361 mknflemhql
//
