LOCUS       NM_023976               4641 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus periaxin (Prx), mRNA.
ACCESSION   NM_023976 XM_218354
VERSION     NM_023976.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4641)
  AUTHORS   Guo,T., Zhang,L., Xiao,H., Yang,Y. and Shi,Y.
  TITLE     Ezrin interacts with L-periaxin by the 'head to head and tail to
            tail' mode and influences the location of L-periaxin in Schwann
            cell RSC96
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (4), 129520 (2020)
   PUBMED   31931020
  REMARK    GeneRIF: Ezrin interacts with L-periaxin by the ''head to head and
            tail to tail'' mode and influences the location of L-periaxin in
            Schwann cell RSC96.
REFERENCE   2  (bases 1 to 4641)
  AUTHORS   Yang,Y. and Shi,Y.
  TITLE     L-periaxin interacts with S-periaxin through its PDZ domain
  JOURNAL   Neurosci Lett 609, 23-29 (2015)
   PUBMED   26467811
  REMARK    GeneRIF: the two periaxin isoforms interacted in the cytoplasm
            through the PDZ domain, and their interaction prevented the
            homodimerization of L-periaxin. S-periaxin may regulate the
            function of L-periaxin in Schwann cells
REFERENCE   3  (bases 1 to 4641)
  AUTHORS   Shi,Y., Zhang,L. and Yang,T.
  TITLE     Nuclear export of L-periaxin, mediated by its nuclear export signal
            in the PDZ domain
  JOURNAL   PLoS One 9 (3), e91953 (2014)
   PUBMED   24633211
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4641)
  AUTHORS   de Morree,A., Droog,M., Grand Moursel,L., Bisschop,I.J.,
            Impagliazzo,A., Frants,R.R., Klooster,R. and van der Maarel,S.M.
  TITLE     Self-regulated alternative splicing at the AHNAK locus
  JOURNAL   FASEB J 26 (1), 93-103 (2012)
   PUBMED   21940993
REFERENCE   5  (bases 1 to 4641)
  AUTHORS   Darbas,A., Jaegle,M., Walbeehm,E., van den Burg,H., Driegen,S.,
            Broos,L., Uyl,M., Visser,P., Grosveld,F. and Meijer,D.
  TITLE     Cell autonomy of the mouse claw paw mutation
  JOURNAL   Dev Biol 272 (2), 470-482 (2004)
   PUBMED   15282162
REFERENCE   6  (bases 1 to 4641)
  AUTHORS   Malik-Hall,M., Poon,W.Y., Baker,M.D., Wood,J.N. and Okuse,K.
  TITLE     Sensory neuron proteins interact with the intracellular domains of
            sodium channel NaV1.8
  JOURNAL   Brain Res Mol Brain Res 110 (2), 298-304 (2003)
   PUBMED   12591166
REFERENCE   7  (bases 1 to 4641)
  AUTHORS   Sherman,D.L., Fabrizi,C., Gillespie,C.S. and Brophy,P.J.
  TITLE     Specific disruption of a schwann cell dystrophin-related protein
            complex in a demyelinating neuropathy
  JOURNAL   Neuron 30 (3), 677-687 (2001)
   PUBMED   11430802
REFERENCE   8  (bases 1 to 4641)
  AUTHORS   Gillespie,C.S., Sherman,D.L., Fleetwood-Walker,S.M., Cottrell,D.F.,
            Tait,S., Garry,E.M., Wallace,V.C., Ure,J., Griffiths,I.R., Smith,A.
            and Brophy,P.J.
  TITLE     Peripheral demyelination and neuropathic pain behavior in
            periaxin-deficient mice
  JOURNAL   Neuron 26 (2), 523-531 (2000)
   PUBMED   10839370
REFERENCE   9  (bases 1 to 4641)
  AUTHORS   Dytrych,L., Sherman,D.L., Gillespie,C.S. and Brophy,P.J.
  TITLE     Two PDZ domain proteins encoded by the murine periaxin gene are the
            result of alternative intron retention and are differentially
            targeted in Schwann cells
  JOURNAL   J Biol Chem 273 (10), 5794-5800 (1998)
   PUBMED   9488714
REFERENCE   10 (bases 1 to 4641)
  AUTHORS   Gillespie,C.S., Sherman,D.L., Blair,G.E. and Brophy,P.J.
  TITLE     Periaxin, a novel protein of myelinating Schwann cells with a
            possible role in axonal ensheathment
  JOURNAL   Neuron 12 (3), 497-508 (1994)
   PUBMED   8155317
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Z29649.2.
            
            On or before Jan 12, 2005 this sequence version replaced
            XM_218354.2, NM_023976.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z29649.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4641
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4641
                     /gene="Prx"
                     /note="periaxin"
                     /db_xref="GeneID:78960"
                     /db_xref="RGD:619960"
     exon            1..30
                     /gene="Prx"
                     /inference="alignment:Splign:2.1.0"
     exon            31..74
                     /gene="Prx"
                     /inference="alignment:Splign:2.1.0"
     exon            75..173
                     /gene="Prx"
                     /inference="alignment:Splign:2.1.0"
     exon            174..299
                     /gene="Prx"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..4424
                     /gene="Prx"
                     /codon_start=1
                     /product="periaxin"
                     /protein_id="NP_076466.2"
                     /db_xref="GeneID:78960"
                     /db_xref="RGD:619960"
                     /translation="MEARSRSAEELRRAELVEIIVETEAQTGVSGFNVAGGGKEGIFV
                     RELREDSPAAKSLSLQEGDQLLSARVFFENFKYEDALRLLQCAEPYKVSFCLKRTVPT
                     GDLALRPGTVSGYEMKGPRAKVAKLNIQSLSPVKKKKMVIGTLGTPADLAPVDVEFSF
                     PKFSRLRRGLKADAVKGPVPAAPARRRLQLPRLRVREVAEEAQVARMAAAAPPSRKAK
                     SEAEVATGAGFTAPQIELVGPRLPSAEVGVPKVSVPKGTPSTEAASGFALHLPTLGLG
                     APAAPAVEPPTTGIQVPQVELPTLPSLPTLPTLPCLDTQEGAAVVKVPTLDVAAPSVE
                     VDLALPGAEVEAQGEVPEVALKMPRLSFPRFGVRGKEATEAKVVKGSPEAKAKGPRLR
                     MPTFGLSLLESRPSGPEVAAESKLKLPTLKMPSFGISVAGPEVKAPKGPEVKLPKVPE
                     IKLPKAPEAAIPDVQLPEVQLPKMSDMKLPKIPEMAVPDVHLPEVKLPKVPEMKVPEM
                     KLPKIPEMAVPDVHLPDIQLPKVPEMKLPDMKLPKVPEMAVPDVHLPDIQLPKVPEMK
                     LPDMKLPKVPEMAVPDVRIPEVQLPKVSEVKLPKIPDMAVPDVRLPELQLPKMSEVKL
                     PKIPDMAVPDVRLPEVQLPKVSELKLPKVPEMTMPDIRLPEVQLPKVPDIKLPEIKLP
                     KVPEMAVPDVPLPELQLPKVPQVPDVHLPKVPEMKLPKVPEAQRKSAGAEQAEKTEFS
                     FKLPKMTVPKLGKVTKPGEAGIEVPDKLLILPCLQPEVGTEVARVGVPSLSLPSVELD
                     LPGALGLEGQVQEAVSGKVEKPEGPRVAVGTGEAGFRVPSVEIVNPQLPTVEVKKEQL
                     EMVEMKVKPTSKFSLPKFGLSGPKAVKAEVEGPGRATKLKVSKFAISLPRARAGTDAD
                     AKGAGEAGLLPALDLSIPQLSLDAQLPSGKVEVAGAESKPKGSRFALPKFGAKGRDSE
                     ADVLVAGEAELEGKGWGWDGKVKMPKLKMPSFGLSRGKEAEIQDGRVSPGEKLEAIAG
                     QLKIPEVELVTPGAQETEKVTSGVKPSGLQVSTTRQVVAEGQEGAQRVSSLGISLPQV
                     ELASFGEAGPEIAAPSAEGTVGSRIQVPQVMLELPGTQVAGGDLLVGEGIFKMPTVTV
                     PQLELDVGLGHEAQAGETAKSEGGLKLKLPTLGAGGKGEGAEAQSPEAQHTFHISLPD
                     VELTSPVSSHAEYQVVEGDGDGGHKLKVRLPLFGLARAKEGIETGEKVKSPKLRLPRV
                     GFSQSESASGEGSPSPEEEEEGSGEGASGRRGRVRVRLPRVGLASPSKGSKGQEGDAA
                     SKSPVGEKSPKFRFPRVSLSPKARSGSKDREEGGFRVRLPSVGFSETAAPGSARIEGT
                     QAAAI"
     exon            300..456
                     /gene="Prx"
                     /inference="alignment:Splign:2.1.0"
     exon            457..653
                     /gene="Prx"
                     /inference="alignment:Splign:2.1.0"
     exon            654..4626
                     /gene="Prx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaactctgg aggtgtctgg aggcccactg agccccagac ccaggaggcc caagtagctg
       61 gaactgaccc tcaggcagca agacctcaaa ggaagagtga aattccggct tacagctgta
      121 catcaccccg agtggggctc ctgtcaggag aaaagaccat cacccaggaa gcggctcagc
      181 ggcagctgct ccatgaggag ctgaagctgg tcctacagca gaaggaggag aggaaacagg
      241 agcctgagcc ccaggtgact ctctgcagag ctatggaggc caggagccgc agcgctgagg
      301 agctgagacg agcggagttg gtggagatta tcgtggagac agaggcgcag accggggtca
      361 gcggcttcaa tgtagcaggc ggcggcaaag aaggaatctt tgtccgcgag ctgcgagagg
      421 actcaccggc cgccaagagc ctcagtttgc aggaagggga ccaacttctg agcgcccgtg
      481 tgttctttga gaacttcaaa tatgaggatg cactacgcct gctgcaatgt gccgagccct
      541 acaaggtctc cttctgcttg aagcgcactg tgcccaccgg ggacctggca ctgcggcccg
      601 ggacggtgtc tggatacgag atgaagggcc cgcgggccaa ggtggccaag ctgaacatcc
      661 agagtctgtc ccctgtgaag aagaagaaga tggtgattgg gaccctgggg acccctgcag
      721 atttggcccc tgttgacgtc gagttctctt ttcccaagtt ctcccgattg cgtcggggcc
      781 ttaaagccga tgctgtcaag ggacctgtcc cagctgcccc tgcccgacga cgtctccagc
      841 tgcctcggct acgtgtccga gaagtagctg aagaggccca ggtagcccga atggctgctg
      901 ctgctcctcc ctctaggaag gccaagtcag aggctgaggt agccacaggg gctggattca
      961 cagcccctca gatagagcta gttgggcctc ggctgcctag cgcagaggtg ggtgtcccta
     1021 aggtctcagt tcccaaggga accccatcaa cagaggcagc cagcggcttt gcccttcacc
     1081 tgccaaccct tgggctagga gccccagctg caccggctgt ggagccccca accacaggaa
     1141 tccaggtccc gcaagtggaa ctccccaccc tgccctcttt acccactctg cccacacttc
     1201 cgtgcctaga tacccaggaa ggggctgcag tggtcaaagt ccccaccctg gatgtggcag
     1261 ctccgtctgt ggaggtggac ctggctttgc caggtgcaga ggtggaggcc cagggagagg
     1321 tacctgaagt ggctctcaag atgccccgtc tcagtttccc ccgttttggg gttcgaggga
     1381 aggaagctac tgaagccaag gtagtcaagg gcagccctga ggccaaagca aagggtccca
     1441 gacttcgaat gcccaccttt gggctttctc tcctggaatc ccggccctct ggccctgaag
     1501 ttgctgctga gagcaagctg aagctaccca ccctcaagat gccctctttc ggcatcagcg
     1561 tagctgggcc tgaggtcaag gcacccaaag ggcctgaagt gaagctcccc aaagttcctg
     1621 agatcaaact cccgaaagcg ccagaggcag ccattccaga tgtgcaactc cccgaggtac
     1681 agctgcccaa aatgtcagac atgaaacttc caaagatccc tgagatggct gtacccgatg
     1741 ttcaccttcc ggaagtgaag ctgcccaaag tccccgagat gaaagtccca gaaatgaagc
     1801 ttccgaagat cccggagatg gccgtgcctg atgtacacct tccagatata cagctcccga
     1861 aagttcccga gatgaagctc ccagacatga agctcccgaa ggtgcctgag atggccgtgc
     1921 ctgatgtaca ccttccagat atacagctcc cgaaagttcc cgagatgaag ctcccagaca
     1981 tgaagctccc gaaggtgcct gagatggccg tgcctgatgt acgaattccg gaagttcagc
     2041 tacccaaagt gtccgaggtg aagctcccga agataccgga catggccgtg cctgatgttc
     2101 gcctcccaga gctgcaactg cccaaaatgt ctgaggtgaa gctcccgaag ataccggaca
     2161 tggccgtacc tgatgttcgc ctcccagaag ttcagctacc caaagtgtca gagctgaagc
     2221 tcccgaaggt gcctgagatg accatgcccg acattcgcct cccggaagtt cagctgccca
     2281 aagtgcctga cattaaactt ccagaaataa aactccccaa agtgcctgag atggccgtgc
     2341 ctgatgtccc ccttccagaa ctacagctgc ccaaagtgcc acaggtccca gacgtgcatc
     2401 ttcccaaagt gccagagatg aagttgccca aggttcctga ggcacagagg aaatctgcag
     2461 gggcggagca ggcagaaaag accgaattta gcttcaagtt gcccaagatg actgtgccca
     2521 agttggggaa agtgaccaag cctggggagg caggtattga ggttccagac aaactcctga
     2581 tacttccctg tctgcagcca gaggtgggca ctgaggtggc ccgtgttggt gtcccttccc
     2641 tctctctccc ttctgtggag cttgacttgc ctggggccct gggcctggag ggacaagtcc
     2701 aagaagctgt ctctggcaaa gtggagaagc cagagggccc cagggtggca gtagggactg
     2761 gagaggcggg cttccgcgtg ccctctgtgg agattgtcaa tcctcagctg cccacggttg
     2821 aagtcaagaa agagcagcta gagatggtgg agatgaaagt caaacccact tccaagttct
     2881 ctctgcccaa atttggactt tcagggccca aagctgtcaa ggcagaggtg gaggggcctg
     2941 ggcgagccac caagctgaag gtatccaagt ttgccatctc gcttcccaga gctcgagcag
     3001 ggactgacgc ggacgcgaag ggagctgggg aagcggggtt gctgcctgcc ctcgatctgt
     3061 ccatcccaca gctcagcctg gatgctcaac tgccctcagg caaggtggag gtagcagggg
     3121 ctgagagcaa gcctaaaggg tccagatttg ctctgcccaa gtttggggcg aaaggccggg
     3181 actctgaagc cgacgtactg gtggcagggg aggctgagct ggaggggaag ggttggggct
     3241 gggacgggaa ggtgaagatg cccaagctga agatgccatc ttttgggctg tcccgaggaa
     3301 aagaagcaga aattcaggat gggcgtgtca gcccaggaga aaagctggaa gccatagctg
     3361 ggcagcttaa gatccctgag gtggaactgg tcacaccagg agctcaggag acagagaagg
     3421 tcaccagtgg agtgaagcca tcaggcctcc aggtgtccac cactaggcag gtggttgcag
     3481 agggccagga gggggcgcag agggtgtcct cattaggtat ctctttgccc caggtggaac
     3541 tggccagctt tggggaggca ggccctgaga tcgcagcccc atctgcagag ggcacagtag
     3601 gctctaggat ccaggtgcca caggtgatgc tggagttgcc gggaacccag gtggcagggg
     3661 gtgatctgtt agtgggtgag ggcatcttca agatgcccac agtgacagtg ccccagttag
     3721 agctggatgt ggggttgggc catgaagccc aggctggtga aacagccaag agtgagggcg
     3781 ggttaaagct gaagttgccc acactggggg caggaggcaa aggagagggt gctgaggccc
     3841 agagccccga ggcccagcac accttccaca tctcattgcc tgacgtagaa ctcacatcac
     3901 cagtgagtag ccacgctgag taccaggtgg ttgagggcga tggggatggc gggcacaaac
     3961 tcaaggtgcg gctgcccctg tttggtctgg caagggccaa ggaaggaata gaaactggag
     4021 aaaaggttaa aagtccaaag ctcaggctac cccgagtggg cttcagccaa agtgagtcgg
     4081 cctctggaga aggctctccc agtcctgagg aggaggaaga aggcagtggg gaaggggctt
     4141 ccggtcgccg tggtcgggtc agggtccgct tgcctcgtgt aggcttggct tccccttcta
     4201 aaggctctaa gggacaggag ggtgatgcgg cctccaagtc cccagttggg gagaagtccc
     4261 ccaagttccg ctttcctagg gtgtccttaa gccccaaggc ccggagtggg agtaaggacc
     4321 gggaagaagg tggattcagg gtccgactgc ccagtgtggg attttcagaa acagcagctc
     4381 caggctccgc caggattgag gggacccagg ctgctgccat ctgaagccct gggacagctg
     4441 tggattcccc ctcttgtctt cccatcccca tccctgctcc ccattttatg tgtgacatta
     4501 ctagcactaa tcctcagagg gcttgaaggt gggcagctga ctcaggcagg agcggtctgt
     4561 gccacctcat tggctgacgt gcctgtatat catgccaagc tctgtgaata aaataattca
     4621 aaagttaaaa aaaaaaaaaa a
//
