LOCUS       NM_001419567           12491 bp    mRNA    linear   ROD 19-FEB-2024
DEFINITION  Rattus norvegicus prune homolog 2 with BCH domain (Prune2), mRNA.
ACCESSION   NM_001419567 XM_017590322
VERSION     NM_001419567.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12491)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000047.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001419567.2.
            
            On Apr 11, 2023 this sequence version replaced XM_017590322.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JACYVU010000047.1  1373785-1373958
            175-279             JACYVU010000047.1  1419938-1420042
            280-482             JACYVU010000047.1  1423563-1423765
            483-646             JACYVU010000047.1  1426415-1426578
            647-796             JACYVU010000047.1  1434079-1434228
            797-891             JACYVU010000047.1  1436205-1436299
            892-1047            JACYVU010000047.1  1538975-1539130
            1048-7594           JACYVU010000047.1  1543924-1550470
            7595-8351           JACYVU010000047.1  1550841-1551597
            8352-8431           JACYVU010000047.1  1593088-1593167
            8432-8632           JACYVU010000047.1  1601363-1601563
            8633-8806           JACYVU010000047.1  1612838-1613011
            8807-8909           JACYVU010000047.1  1619038-1619140
            8910-9041           JACYVU010000047.1  1619687-1619818
            9042-9128           JACYVU010000047.1  1621463-1621549
            9129-9227           JACYVU010000047.1  1629903-1630001
            9228-9263           JACYVU010000047.1  1633718-1633753
            9264-9302           JACYVU010000047.1  1634290-1634328
            9303-9350           JACYVU010000047.1  1638305-1638352
            9351-12491          JACYVU010000047.1  1642482-1645622
FEATURES             Location/Qualifiers
     source          1..12491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..12491
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /note="prune homolog 2 with BCH domain"
                     /db_xref="GeneID:293823"
                     /db_xref="RGD:1311350"
     exon            1..174
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..9381
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /note="BNIP2 motif-containing molecule at the C-terminal
                     region 1"
                     /codon_start=1
                     /product="protein prune homolog 2"
                     /protein_id="NP_001406496.1"
                     /db_xref="GeneID:293823"
                     /db_xref="RGD:1311350"
                     /translation="MEEFLQRAKSKLDRSKQLEQVHAVIGPKSCDLDSLISTFTYAYF
                     LDKVSPPGVLCLPVLNIPRSEFNYFTETRSILEELNISDSFHIFRDEINLQRLNDEGK
                     LSITLVGSHVLGSEDRTLESAVVRVINPGEQSDGELGFAESSSSLVLKELLREAPELI
                     TQQLAHLLRGSILFKWMTMDPELPEKQEEILSILEEQFPNLPPRDDVISVLQESQLSA
                     QGLSLEQTMLKDLKELSDGEIKVAISTVNMTLEDCLLHSNITSDLKAFTDKFGFDVLI
                     LIASYTSEEQQRQQIAVYSQNPELCSQICCELEESHNPCLELEPFECGCDEILVYQQE
                     DPSVTCDQVFLLLKEVINRRCAEMVSNSRTSSTEAVAGSAPLSQGSSGIMELYGSDIE
                     PQPNSVNFIENPPELNDSNQAQVDVNIDLVSPDSGLATIRSSRSSKESSVFLSDDSPV
                     GEGGGPHHSLLPGFESYSPIPEGIVAEEHARSGEQSEHFDLFNFDPAPIASEQSQPSS
                     HSADYSPDDFPNSDSSEGNLSAGPKGLGEMGINMSNYSSSSLLSEAGKDSLVEFDEEF
                     VQRQESSGDNSERNLSLTCFVGEEPASPERLKNTGKRIPPTPMNSFVEISPSTEEPTP
                     LYPEEIIQNTIDAGHLGPPQTRARCRSWWGGLEIDSKNIVDAWNSSEQESVFQSPEPW
                     KDHKPEPVERRTSDCTFQPKSLGFPNSDPWESEFGQPELGSKDTQDQTEESLQYQHSP
                     TVRPHLTDASAQGTNHLIEDFAALWHSGHSPTTMPEPWGNPTDADEAAVTMSFPTWGA
                     FDKEDNADTLKNTWNLHPTNNETPSVQDPSGWAMAQSGFSFPAGDLLDNSLIEVNKDA
                     APEIWGKKNNDSKDNSLTSRSPISDLGQTWNNSKLPGEDQDDLVDPKARGKVYEKEGS
                     WNLFEESIKKRGADVLAPWEDSFLSYKCSDYSASNIGEDSVPSPLDTNYSTSDSYTSP
                     TCAGEEKETESKPIAKDNGFGARDADFPAEGVEVLATSPQQPQRNRIGSGPGNLDMWA
                     LPHAEDKPEGNDTHHPEKDSLKIEHAEDKNASLEDDMGESSPSSYDDPSMMQLYNEAN
                     RQLTLLHSNNNSRQTAPDSLDTWNRVILEDTQSTATISDMDNDLDWDDCSGGVAIGGD
                     GQAGGYVAANSEPETRFSVKQLEPWGTEHQEANQVDWDLSASAEATGDTGPSEYHTLN
                     VKSGQLIANSIWDSVMGDKDMPSFRLPSPPNTVDMEHGAWPSESFRHSINGKDGHMSE
                     ASGLSESEGLTSHPDNQDTWADSLGNTASSVARLTSSEHFAQSDSWTGHIYGQSESEI
                     ESLTASDCDHLDKETAEGSGVNGAPWVFGKEPIDQELSSSDAFEHQEICNASGKVSSL
                     SVTSSPQSEESEEALEVEKEPYTLDSLAGQTETPTSDSQTKDTHEESLMDNRNLEEAN
                     TTLDRINLIKNMPLSEMELEETEACNILRPERENGKLIYESSQNFGVWDGPTDSDVWD
                     SHISYEIAMNPTCQRTEERSLEALSPGNYDKDSLSSECTRSSASSPDLNDSSVALSSW
                     TYGPSADHQNENQDDRNKQIHQEPELFTTEAHVGVITEMKDFAKPRKDEFGNMSDQED
                     PQFPAISNDPFNGGSSSSSSSLGTDKYSEYSHAYQEGNLMTRGQEENELNSLEIAEPE
                     GSRIISTSSGSGHDSGGEEELLEKELHLATVAQRESEVCNSLPDPEFLVTEQSKPELS
                     VFVGSSEPIENENKSSPFYDSQQSSPGQWILSPLVQADIQDTSKEEEARGADTGTVMD
                     TMWQGSASTDRKNGDPDTLEMLGFSTDSSEWWNPAARDGKATASVSAEELSNSEGELE
                     TTSPIFQNAGPWSVPVQDDSKPVDTGSTNPFSGELKSPFLDSDGDKSQEKLWNIQPKQ
                     LDSDANQFSQLVILDQIKDKDSGQQTAMSSTAGDLPSETLAQEQCQESMLSVWDHAGP
                     ALTHRDENGCVSAGISPTECQQENGWEPEKSYLSHVTHSRTPTENLDKINAPTQLIRK
                     PDSDWDSPSPSEHQHNFVPDILHGNFEEGGQLASASPDLWMDVKQPFTFRADGENPDI
                     LTHCDQDSNSQTSSSPDVCHDSEGKQEMETHTGVYLGPEVEPSEFYLTEPNMDDEPTR
                     EPEQECLPCNSELYSEDAMPLPPINSQKDTDNLSKPASSKSSPDPSDMHGDISTSITA
                     LDEGANPEVEEAVDRTIPGTRSEDADTFETHQEVGEEGSWISKDLCPENQTGTRAQLD
                     REQPFASESPAVLTDIFLASDTCLDVSEAALDHSFSDASGINTSTGTIDDMSKLTLSE
                     GHPETPVDGDAGKHDICSSEASWGDFEYDAMGQNIDEELMREPEHFLYGSDLPSEEGT
                     TKQSLAPYTPPFDLSYLTEPSGYAESTQGAESPDDASLGSDAAEMLLSALPDQRKEDK
                     AETNIRKPGYQMTVLHIHEDPEALSSPVGGTGSNKESSPSNIDWEIETDNSESPVGGD
                     MKPPNGKEILEFEDEKVVPTKGPEQTKLEYKEEKQAGKSEDHQVLAVDYILVNHENDS
                     PLKPEAREARENRAESEQFSIGSEERELPETQQAGIPDTCQPESLNDVKVHSAERMSS
                     NHKNTSLENPVQDQSWMVLSHSEVGDPPAETRDSGAGSPGRTVEPFLSLSLDKGPQSQ
                     VLERKKPLDSLALGEVAALSSQSRKSKRQGQAGLDAVPTQAATHDNEWEMLSPQFSQK
                     NRNPPQEMQEETRVPEPGPRKPRPKGPPSEDEGMDIHFEEGVLSPSATDMRPEPPNSL
                     DLNGSHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEY
                     PGHEDPMANRSSGQESESIPEYTAEEEREDNRLWRTVVIGEQEQRIDMKVIEPYRRVI
                     SHGGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAEDYMIVYLN
                     GATPRRKMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFISSKFSS
                     KIKYVSSLSELSGLIPMDCIHIPESIIKYDEEKSFKRSVRLDEELREASEAAKTSCLY
                     NDPEMTSMEKDIDMKLKEKP"
     exon            175..279
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            280..482
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            483..646
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            647..796
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            797..891
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1047
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..7594
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            7595..8351
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            8352..8431
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            8432..8632
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            8633..8806
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            8807..8909
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            8910..9041
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            9042..9128
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            9129..9227
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            9228..9263
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            9264..9302
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            9303..9350
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
     exon            9351..12491
                     /gene="Prune2"
                     /gene_synonym="Bmcc1; RGD1311350"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccggcc ggcccgccta gggagcggct ggtccctgcg cagagcgacc actttctaga
       61 gatcccgttc aagtccccgc agctctcctc tctcggcgct ctccatccgg acccctggtc
      121 ccagtcccta gcagagacat ggaagaattt ttgcaacgcg ccaaatctaa actggatcga
      181 agtaaacagt tggagcaggt ccatgcggtt attggaccta agtcatgtga cctggattct
      241 ctcatttcta ccttcacata tgcatatttt ctggacaagg tcagtcctcc tggggtcctc
      301 tgcttgccag tgctgaatat cccaagaagt gaattcaact acttcacaga gacaaggtct
      361 attttagaag agctgaacat ctctgactca ttccacatat tccgagatga gattaacctg
      421 cagcgactga atgatgaagg gaagctatca ataacgctcg tgggcagcca cgtcctgggg
      481 agcgaggaca gaactttgga atccgccgtt gtcagagtca ttaaccctgg agaacagagt
      541 gatggtgagc tgggctttgc ggagtcttcc tcctcactag tgctgaagga gctcctgcgt
      601 gaggctccgg agctcatcac tcagcagctg gcacatctcc tcagaggcag catcctgttc
      661 aaatggatga ccatggatcc tgagctccca gagaagcagg aggaaattct ctccatcctg
      721 gaagaacagt ttcccaacct gcctccaagg gacgatgtca tcagtgtgct gcaggagagc
      781 cagctcagtg ctcagggttt aagtcttgaa caaacaatgt tgaaagatct aaaggagctg
      841 tcagacggtg aaataaaagt ggccatcagc accgtgaaca tgaccctgga ggactgcctg
      901 cttcatagca acatcaccag tgatttgaaa gccttcacag acaagtttgg ctttgatgtc
      961 cttatcctga tcgcgagcta cacatcggag gagcagcaaa ggcagcagat cgctgtgtac
     1021 tcccagaacc cggaactgtg cagccagatt tgctgtgagc tggaagaaag tcacaaccct
     1081 tgtctggaac tggagccctt tgaatgtggc tgtgatgaga tactggtgta tcagcaggag
     1141 gacccttctg tgacctgtga tcaggtgttt cttcttctca aagaggtcat aaataggagg
     1201 tgtgcagaga tggtctctaa cagtcggaca tcctcaacag aagctgtggc gggcagtgcg
     1261 cctctgtccc agggctcttc tgggattatg gaattgtatg gttctgacat agagccacag
     1321 cccaactctg tgaatttcat agaaaaccct ccagagctca acgattctaa ccaagctcag
     1381 gtggatgtca acatagacct tgttagccct gacagtgggt tggccactat cagaagcagt
     1441 cgctcatcca aggagagctc agtcttcctc agtgatgaca gcccagtggg agagggtggc
     1501 gggcctcacc acagccttct cccaggattt gaatcctaca gccccattcc tgaaggcata
     1561 gttgcagagg agcatgcacg ctccggggaa caaagtgaac attttgacct cttcaacttt
     1621 gacccagcac ccatagcttc tgagcagtcc cagccatctt cccattcggc agactactca
     1681 ccagatgact ttcccaacag tgattcatca gaaggaaacc tctctgctgg gcctaaggga
     1741 cttggtgaga tggggatcaa catgtccaat tactcctcta gttctctttt gtcagaggct
     1801 ggtaaagaca gccttgtgga atttgatgaa gagtttgtcc agagacaaga aagctcaggc
     1861 gataactctg aaagaaattt aagcctgaca tgttttgtgg gagaggaacc tgcttcccct
     1921 gaaaggctga agaatactgg gaaaaggatc ccaccaacac ctatgaacag ctttgttgaa
     1981 atctcaccat caactgaaga gccaactcca ctctatcctg aggaaataat ccaaaataca
     2041 attgatgcag gacatctggg cccacctcag acccgtgcac ggtgcagaag ttggtggggt
     2101 ggcttggaaa ttgactctaa aaatattgta gatgcatgga actccagtga acaagaatct
     2161 gtcttccaga gccctgaacc atggaaagat cataagcctg aaccagttga gaggagaacc
     2221 tcagattgca cattccaacc aaagagtctt ggattcccaa actcagatcc atgggaatct
     2281 gaatttgggc agcctgaact gggcagcaaa gatacccagg accagacgga agaaagcttg
     2341 caatatcagc actcgcctac agtgaggcca catttgacag atgcctctgc tcaagggaca
     2401 aaccacctga tagaggactt cgctgctttg tggcattcag gacactcacc cacaacaatg
     2461 cctgagccct ggggaaaccc cacagatgct gatgaagctg cagttacgat gtccttcccc
     2521 acctggggtg catttgataa agaagataat gcagacacat taaaaaatac ttggaatctt
     2581 catcccacta acaatgagac tccttctgtg caggacccaa gtggatgggc tatggcccaa
     2641 agtgggtttt ctttccctgc aggagaccta ctggacaatt ccctcattga ggtaaataaa
     2701 gatgcagctc cagagatctg gggcaagaag aacaatgact caaaggataa cagtcttaca
     2761 tctagaagtc ccatttctga tctgggtcaa acatggaata attctaagct accaggggaa
     2821 gaccaggatg acttggtgga tcctaaagcc agagggaagg tatatgaaaa ggaagggtcc
     2881 tggaacctct ttgaggagag tattaagaaa agaggagctg atgtcttagc tccttgggaa
     2941 gattccttct tgtcctataa atgctctgat tacagtgcgt ccaacatagg agaagattca
     3001 gtcccatctc ccttagacac caactactcc acttctgact cttacacatc accaacatgt
     3061 gctggagagg aaaaagaaac ggaaagcaag ccaattgcta aagataatgg ttttggggca
     3121 agagatgctg attttcctgc agagggcgtt gaggttcttg caacatcacc acagcagcct
     3181 cagagaaatc gaattggttc tggtcctggg aacctagaca tgtgggcatt gcctcatgca
     3241 gaagataagc ctgaaggaaa tgacacacat cacccagaga aagattcact caagatagag
     3301 catgcagaag ataaaaatgc ttccctggag gatgacatgg gagaaagcag tccatccagt
     3361 tacgatgacc ctagcatgat gcaactatac aatgaggcaa accggcagct cacccttcta
     3421 cacagcaaca acaactcacg ccagacagcc cctgacagcc ttgacacatg gaaccgagtg
     3481 attctggagg acacgcagtc cactgcaacg atctcggaca tggataatga cttggattgg
     3541 gatgactgca gtgggggtgt ggcgatcggt ggtgatggtc aagcaggagg ttatgtagct
     3601 gcaaatagtg aacctgaaac ccggttctca gtgaagcagc tggaaccatg gggcacagag
     3661 catcaggaag caaatcaggt agactgggat ctctccgcct ctgctgaggc cacaggggac
     3721 actggtccca gtgaatacca tactctgaat gtgaaaagtg ggcagttaat tgccaacagt
     3781 atttgggatt cagtcatggg agataaagac atgccatcat tcagactacc aagcccacca
     3841 aatactgtag atatggaaca tggtgcttgg ccttctgaaa gtttcaggca ttcaataaat
     3901 gggaaggatg gccacatgtc agaagcctct ggactcagtg agtcagaagg gcttacatct
     3961 catcctgaca accaggacac atgggcagac tccctaggta acacagcatc ctcggtggcc
     4021 aggctgacaa gttcagaaca ctttgcccag tcagattcat ggacaggcca tatttacggg
     4081 cagagtgaaa gtgagattga aagcctgaca gcctctgatt gtgaccatct cgacaaggag
     4141 acagccgaag gctctggagt gaatggtgcc ccatgggttt ttggcaaaga gcccattgac
     4201 caggaactct cttcttcaga tgcatttgaa caccaagaaa tttgcaacgc atcaggcaaa
     4261 gtcagctctc tctcagtcac ctccagtcct cagagtgagg agtcagagga ggccttagaa
     4321 gttgagaagg agccttacac tctagactcc cttgctggac aaacagagac acccacaagt
     4381 gattctcaga caaaagacac ccatgaagaa tctcttatgg ataatagaaa tctggaggaa
     4441 gccaacacga cattagatag gattaatcta ataaaaaata tgcctttatc tgaaatggaa
     4501 ttggaggaaa ctgaagcctg caacattctg aggccagaaa gagaaaatgg aaaactaatt
     4561 tatgaatcgt ctcaaaactt tggtgtttgg gatggcccta cagatagcga tgtgtgggac
     4621 agtcatataa gttatgagat agctatgaac cctacatgtc agagaactga ggaaaggtct
     4681 ctggaagccc tttcaccagg aaattatgac aaagacagcc tctctagtga gtgcactcgt
     4741 tccagtgcat cgagtcctga cctaaatgat tcctcagttg ctttgtcctc ctggacctac
     4801 ggacccagtg ctgaccatca gaatgagaat caagatgata gaaacaaaca gattcaccaa
     4861 gaaccagaac tgtttaccac tgaagcccat gtgggagtca ttacggaaat gaaggacttt
     4921 gcaaaaccca ggaaggatga atttggaaac atgtctgatc aggaggaccc tcaatttcca
     4981 gcaatctcaa atgatccctt caatggtggt tcctcatcct cttcatccag ccttggaaca
     5041 gataaatatt ccgaatattc tcatgcatat caggaaggaa atctaatgac tagaggtcaa
     5101 gaggaaaatg aacttaactc tctggaaatt gcggagccag agggttccag gatcatatcc
     5161 acaagctcag gctctggcca tgacagtggg ggtgaggaag agttgctcga gaaagagcta
     5221 catctggcca cagttgctca gcgtgagtct gaggtttgca attcattgcc tgatcctgag
     5281 ttcttggtca cagagcaatc caagcctgag ctttctgtct ttgtgggtag ttcagagcca
     5341 atagagaatg agaataagtc aagcccattc tatgacagtc aacaaagcag ccctggtcag
     5401 tggattttgt caccactcgt gcaggctgac atacaggaca catctaagga ggaggaggcc
     5461 agaggtgcag acacggggac agtgatggat accatgtggc agggatctgc cagcactgac
     5521 cgtaagaatg gagaccctga cacattggaa atgcttggct tctcaactga cagcagtgag
     5581 tggtggaatc ctgctgcacg ggatgggaaa gcaactgcca gtgtgtccgc agaggagttg
     5641 tctaactcag agggtgagtt agagacgact tctccaatat tccagaatgc aggtccgtgg
     5701 agcgtgcccg ttcaggatga tagtaaacct gtggacacgg gcagcactaa tcctttcagt
     5761 ggtgaactaa agtcaccctt tctagatagt gatggggaca agtcacagga gaaactttgg
     5821 aacattcaac cgaagcaact ggattcagat gccaatcaat tcagtcagct tgtaatcctg
     5881 gaccaaatta aggacaaaga ttctggacag caaacagcca tgtcttctac tgctggtgac
     5941 cttccttcag aaactctcgc ccaagagcag tgtcaggaat ctatgctgtc ggtctgggat
     6001 catgcagggc cagccttgac tcacagagat gaaaatggat gtgttagcgc tggcatttca
     6061 cccactgagt gccaacaaga gaacgggtgg gaaccagaaa aatcctatct cagccatgtg
     6121 acacattcaa gaactcccac ggaaaatctc gacaagatca atgctcccac acaactgata
     6181 aggaagccgg actctgactg ggatagcccc agccccagtg agcaccagca taactttgtt
     6241 ccagatattt tacatggcaa cttcgaagag ggcgggcagc tggcttcagc ttcacctgat
     6301 ttgtggatgg atgtcaagca gcctttcact tttagagcag atggtgagaa tcctgatata
     6361 ttgactcact gtgaccagga cagcaactct cagacatcca gcagccctga cgtgtgtcac
     6421 gattctgaag gaaagcaaga gatggagaca catactggtg tttatctggg acctgaagtg
     6481 gaacccagtg agttttatct cactgagcca aacatggatg atgaaccgac tcgggaaccg
     6541 gagcaagaat gtctcccatg caattcagaa ctctactcag aagatgcaat gcccttgcct
     6601 ccgatcaaca gtcagaaaga cacagacaac ttatctaagc ctgcctcttc aaaaagttcc
     6661 ccagatccct ctgatatgca tggagacatc agtacaagta taacagcatt ggacgaaggc
     6721 gccaacccag aggtagaaga agcagtggac aggacgatcc caggcaccag aagtgaagat
     6781 gctgacactt ttgaaactca ccaggaggtc ggtgaagaag gctcttggat atcgaaagac
     6841 ctttgtcctg aaaaccagac aggcaccaga gctcagcttg accgtgagca accttttgct
     6901 tcggagagcc ctgctgtact tactgacatc ttcctagcct ctgatacctg cctggatgta
     6961 agtgaagctg ccttggacca cagtttcagt gatgcgtcgg gcatcaacac ttccacgggc
     7021 actatagacg atatgagtaa gttgactcta tcggaaggcc accctgaaac accagttgat
     7081 ggggacgcgg ggaagcatga tatctgttcg tctgaagctt cctggggtga tttcgaatat
     7141 gatgcaatgg gccagaatat tgatgaagag ctgatgagag aacctgaaca cttcctctat
     7201 ggtagtgatc ttccgtccga ggaaggcacg acgaagcaat cactggcacc atacacaccc
     7261 ccctttgact tgtcctacct cacggaaccc agtggctacg cggaaagcac acagggagcc
     7321 gagtccccag acgacgcatc tctgggaagt gatgcagcag agatgctgct ttctgctctc
     7381 cctgatcaaa ggaaggaaga caaggctgag accaacatca ggaaacctgg ataccagatg
     7441 actgtgttgc atattcatga agaccccgag gctctttctt cacctgtagg aggaacgggt
     7501 tccaataaag agtcctctcc atcaaacatt gactgggaaa tagaaacaga taattcagag
     7561 tcaccagtag gtggcgacat gaaaccaccg aacggcaagg agatattgga gttcgaagat
     7621 gagaaagtag ttcccacgaa agggccagag caaacaaaat tagaatacaa ggaagaaaaa
     7681 caggcaggga aaagtgaaga ccaccaggta ctggctgtag attacatact tgtaaaccat
     7741 gaaaacgatt caccactgaa gccagaggcc agggaagcaa gagaaaacag agccgaatcg
     7801 gagcaattct ccataggttc cgaagaaagg gagctaccag aaactcagca agcaggcatc
     7861 ccagacacgt gtcagcctga gtcgttaaat gatgtcaaag ttcattctgc agagagaatg
     7921 tcttccaacc acaagaacac atctcttgaa aaccctgtac aagaccagag ttggatggtc
     7981 ttgagccata gtgaggttgg tgatccacct gcagaaacca gggactcggg agctgggtct
     8041 ccgggtagaa ctgtggagcc attcttgagt ctcagtttgg acaagggccc ccagtcccag
     8101 gttctggaaa gaaaaaagcc tctagattct ttggcactag gggaagttgc tgctttgagc
     8161 agccaatcaa ggaagagcaa gagacaaggt caagctggtc tagatgcagt tccaacccag
     8221 gctgccaccc atgacaatga atgggaaatg ctttcgccac agttctccca gaaaaacagg
     8281 aaccctccac aggaaatgca agaagagaca cgggtccccg agcctggacc cagaaagcca
     8341 agaccaaaag gacccccatc agaggatgaa ggaatggata tccacttcga ggagggagtg
     8401 ttgagtccca gtgccacaga catgaggccg gaacctccca attctctgga tctcaatggc
     8461 agtcacccta gaagaatcaa gctcacagcc ccaaatatca acctctctct ggaccaaagt
     8521 gaaggatcta ttctctctga tgataaccta gacagtccag atgagattga catcaacgtg
     8581 gatgaactcg atacccctga tgaagcagat tcttttgaat accctggcca tgaagatccc
     8641 atggccaaca gaagctctgg tcaagagtca gagtctattc cagagtatac ggctgaagaa
     8701 gagcgagaag acaaccggct atggaggacg gtggtaattg gagagcagga gcagcggatt
     8761 gacatgaagg tcatcgaacc ctataggaga gtcatttctc atggaggata ctatggggac
     8821 ggtctgaatg ccatcattgt gtttgctgcc tgctttctgc cagacagcag ccgggcggat
     8881 taccactatg tcatggaaaa ccttttccta tatgtaataa gtaccttaga gctgatggta
     8941 gcagaagact acatgattgt gtatttaaat ggagcaaccc caaggcggaa gatgccaggg
     9001 ctaggctgga tgaagaaatg ctaccagatg attgacagac ggttgcgcaa gaatttgaag
     9061 tcattcatca ttgtccaccc gtcttggttc atcagaacaa tccttgcagt gactcggcct
     9121 tttataagct caaaattcag cagtaaaatt aaatatgtgt ctagtttatc cgagctcagt
     9181 gggttgatcc ccatggactg catccacatt ccagagagca tcatcaagta cgatgaagag
     9241 aaatctttta aaagaagtgt gagactggat gaagaactga gggaagcatc agaagcggct
     9301 aaaactagct gcctttacaa tgatccagaa atgacttcta tggaaaagga cattgacatg
     9361 aagctaaaag aaaagcccta atggcctgcg ggaggaatcg ctctctgctt cgtgattttg
     9421 ctgggacaca cctacctgga agcgacagaa atggtgacat ctccactttg caccacctgg
     9481 tgccattgga aacctcgggg gggggggggg agggatggga agagaatttg tttacggtta
     9541 acatatttta tgaaatgttg tgtattttcc tatttttgcc aattatgtgc ctcaatgatt
     9601 ttagttgaac cttagcaaga agataggacc ttccatttta ctctgacgtc agtccttggt
     9661 gcagtgggac tcggttcctt agactggtgt ttaccgaaag caaagcctaa ttctgttgtt
     9721 tgacagacat agatacattt ctgtagactg actgaacttc cctgcagagc ttgctctaga
     9781 gttaagatgc acagggcttg ccttgtcctg tgaatgtggc tctctggaac tctatgaaaa
     9841 gctgagcctg aataggacag acagacagat agcaaatccc cttcagctaa ggcatctcct
     9901 cccttcctat ccacatcagt catctttcag tttttcagaa ggaacctggg ctctctaacc
     9961 catgtacact ttactttctg tatctgtttg taaatcgctc ctttacaaca tcactcccta
    10021 atgatctctg aagaacttca tattgtgaaa cttaagatga actgtgcttc aggccacaga
    10081 acaggctcca acctttatgc ttcgtgtgcc aactcccagg tggcccactc agaaattatt
    10141 gggtaacatc gaatcatcca aaattaacac tcggatgcat tgcaagcaca gtctgcttta
    10201 agaaacttaa cgttagggtt ggagatttgg ctcagtggta gagcgcttgc ctaggaagcg
    10261 caaggccctg ggttcagtcc ccagctccgg aaaaaaagaa ccaaaaaaaa aaaaaaaaaa
    10321 gaaacttaac gttaaatgca agtatatact agcctttctg aaatagccca tttcttgttt
    10381 ttagataccc cttatattgt catggccact tccaatctgt gcatctctag cagaggttgg
    10441 caagctatac cgaggctacg acccggtcac tacaaggaaa ggtggtttcc acacttaaca
    10501 gttgaaaaca aaaattaata cttatctgtc tgaagcttct tttgcacctt cttcaccaga
    10561 actgaatact gacaacagac agttctccac aaagaagaaa cactatcttt acaggagaaa
    10621 aaaaaaaagt gtgctgaccc caaatatcca ttcctaccct ggcctccata ctctgtgcat
    10681 ttatttaaat gttttttcca actgagtgca cagaggtggc tgtaatatca tttggttttg
    10741 tcaaaaacat tttttctttc aagataggat ctcaccatgt atccctaaat ggactagaac
    10801 tcactatgta gatcaagctg gcctcaaact tgtggtaatc ctcctgcctt ggcctcccag
    10861 gtgctggcat tacaggcttg caccaccatg tctatgcttg taaaaaaaaa aattcaacat
    10921 ttacagacag tgaaacatca cccatggcct tctgaaaaaa gcggtgggtc cttctcacaa
    10981 aagtgtggct ctcttaacgc atggactcgc cagactcaaa ctgaaaatat ccgaaaaacg
    11041 tttagaatcg ttctccaaag tcatctgtta ccaagtagcc ggcaggcaca gagtgaagac
    11101 attccctgcc tggtggctct gttgaggaga gctgagccct gaagaagccc aggcgccagg
    11161 gttcctctgg ctctatctgc ttttatccgt ttcccatctg tcgtccatac aagctcaccc
    11221 aatatacccg tgccagttcc ctttccttca caaggctcca ccccttactt tcacctgctg
    11281 atccctttca acttagtatc ttttttgacc tttgtcttct tttcaatctc cctcctcatt
    11341 tttttttttt ttttggctaa tttgatagaa aaaccccagt gtcgactagg ctcccacagc
    11401 ctgccctgcc ctttggaagc ccacctcaaa catcatggtg ataatgagta ttgttatcca
    11461 atatcctgat ttgctcacct gcttagcata tcaactccta catgttccat tttggaagat
    11521 gaattacacg gttcctccag ctctgttaaa cctacgatgt tgtgagaact gcagagttcg
    11581 gctgagcaag tctgtagaca tgggactgtt gatagagcgt gcttttcaca accagatatg
    11641 gcaacaggca aacaggcatg ccattcacac ttttctttga gtccgtgtat ggaaaattac
    11701 tcactcatgg tgtgacatag tgaatttagt gtgagcggtt tcaaatcaat gatgtttgga
    11761 atatcctaag gaaggtaata ccattacaat atttaagcac atgctatctt actgtcttca
    11821 aaaaacaagt tactttaatt gcacgtacta gagaaaagct atcatgttca tcaaatgaat
    11881 aggcttctag ggaatcctgg gaaaatagcc cataatcagg tagatgtaac tttcacatcg
    11941 ctctgctcta gggtctgttc cctgcgcatt cttgctttgg tctggactgc caggacctgc
    12001 tttgcacctt ttcctgtaga tttgtagtta agggaacacc aaggagtcat cagggtggga
    12061 gtggttgaag agtgaaaata actaggggtg gagggagacc ccaaagttcc tactgaagcc
    12121 atacagtgtt atatatggtt cctccctagg gcataccgat aagcaaggaa gccaccctcc
    12181 ctagctcaca tacttaggat gtcattttaa gagttccttt atggttctgc acaattcttg
    12241 tcttatccat atgccccagt ggtctgctac ttttaggaat atctaggtgt gcacacatta
    12301 atcttttcta tatctaaaga gttttctacg tgtattggat tgctcagaat aaagtatata
    12361 ttagacttgt tttggtaaag aaataaattc tatctggata gtatggatta aaattatgaa
    12421 aatatgtaag aacacaatgt atctctacac ccctactgtg taactcaaaa aataaaaata
    12481 gattccacac a
//
