LOCUS       NM_001007697            1723 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus prune exopolyphosphatase 1 (Prune1), mRNA.
ACCESSION   NM_001007697 XM_227440
VERSION     NM_001007697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Zollo,M., Ahmed,M., Ferrucci,V., Salpietro,V., Asadzadeh,F.,
            Carotenuto,M., Maroofian,R., Al-Amri,A., Singh,R., Scognamiglio,I.,
            Mojarrad,M., Musella,L., Duilio,A., Di Somma,A., Karaca,E.,
            Rajab,A., Al-Khayat,A., Mohan Mohapatra,T., Eslahi,A.,
            Ashrafzadeh,F., Rawlins,L.E., Prasad,R., Gupta,R., Kumari,P.,
            Srivastava,M., Cozzolino,F., Kumar Rai,S., Monti,M., Harlalka,G.V.,
            Simpson,M.A., Rich,P., Al-Salmi,F., Patton,M.A., Chioza,B.A.,
            Efthymiou,S., Granata,F., Di Rosa,G., Wiethoff,S., Borgione,E.,
            Scuderi,C., Mankad,K., Hanna,M.G., Pucci,P., Houlden,H.,
            Lupski,J.R., Crosby,A.H. and Baple,E.L.
  TITLE     PRUNE is crucial for normal brain development and mutated in
            microcephaly with neurodevelopmental impairment
  JOURNAL   Brain 140 (4), 940-952 (2017)
   PUBMED   28334956
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Reymond,A., Volorio,S., Merla,G., Al-Maghtheh,M., Zuffardi,O.,
            Bulfone,A., Ballabio,A. and Zollo,M.
  TITLE     Evidence for interaction between human PRUNE and nm23-H1 NDPKinase
  JOURNAL   Oncogene 18 (51), 7244-7252 (1999)
   PUBMED   10602478
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079054.1.
            
            On Nov 29, 2004 this sequence version replaced XM_227440.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079054.1, SRR8487226.231991.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1723
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /note="prune exopolyphosphatase 1"
                     /db_xref="GeneID:310664"
                     /db_xref="RGD:1359521"
     exon            1..295
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1621
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /EC_number="3.6.1.1"
                     /note="protein prune homolog"
                     /codon_start=1
                     /product="exopolyphosphatase PRUNE1"
                     /protein_id="NP_001007698.1"
                     /db_xref="GeneID:310664"
                     /db_xref="RGD:1359521"
                     /translation="MEDYLQDCRAALQESRPLHVVLGNEACDLDSMVSALALAFYLTK
                     TSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIAESALIFRDEIDLLALHQAGQLTL
                     ILVDHHMLPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVELVGSCATLVAERILQGA
                     PETLDRQTAALLHGTIILDCVNMDAKIGKATLKDNEYVEKLEALFPDLPKRKDIFDSL
                     QKAKFDVSGLTTEQMLRKDQKTIYRQGTKVAVSAVYMDLEAFLQRSGLLSDLSAFCQD
                     HSYDALVAMAIFFNTHNEPVRQLAIFCPHEALRMTICGVLEQSTSPALKLTPIPSISA
                     HLQAYLQGNTQVSRKKLLPVLQEALSAYLDSMRTPAGQLEAALGMSREQADKELDKAS
                     NSLIAGLSQDDEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTRAC
                     PSNK"
     exon            296..388
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /inference="alignment:Splign:2.1.0"
     exon            389..591
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /inference="alignment:Splign:2.1.0"
     exon            592..776
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /inference="alignment:Splign:2.1.0"
     exon            777..935
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1030
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1189
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1697
                     /gene="Prune1"
                     /gene_synonym="Prune"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgatatgc tcctccttga cctcccatga gcctttgggc tcagaaccca gcctccgccg
       61 ctgggggagg ggtaacgccg gactcccgga gtgccggatt acgcacttcc tcctgggttc
      121 ggaggcagaa ccctttagtg gcgggttcga gtcccgcccc ttgactctcg gctctagacc
      181 ctgagtctgg ggcggggtac attcggccga gttacctctc ctcgctgagg ggctacggca
      241 cacctccggc ttcaccatgg aggactactt gcaggactgt cgagccgctt tgcaggagtc
      301 caggcctcta catgttgtgc tggggaatga agcctgcgac ttggactcca tggtgtctgc
      361 ccttgccctg gccttctacc taacaaagac atctgaagca gaagacatct ttataccagt
      421 tttaaatata aagcgctctg agcttcctct ccgaggggac aatgtcttct tcctccagga
      481 ggttaagatt gcagagtcag cactgatctt ccgggatgag attgacctcc ttgccctgca
      541 ccaggctggc cagctcaccc tcatccttgt tgaccaccat atgttaccca agagcgacgc
      601 agccctggag gaggcagtag ccgaggtgct ggaccaccga ccaatcgagc agaaatactg
      661 tcctccctgt catgtttcag ttgagctggt ggggtcctgt gccaccctgg tggctgagag
      721 aatcctgcag ggggcaccag agaccttgga cagacaaact gcagcccttc tgcatggaac
      781 catcatcctg gactgtgtca atatggatgc caaaattgga aaggcaaccc taaaggacaa
      841 cgaatatgtg gaaaaactgg aggccctttt cccagatctg cccaaaagaa aggacatctt
      901 tgattctctg cagaaggcca agtttgatgt ctcaggattg accactgagc agatgctcag
      961 aaaggaccag aagactatct acagacaagg taccaaggtg gcagtcagtg cagtctacat
     1021 ggatttggag gcctttctgc agcggtcagg cctcctctca gacctcagtg ctttctgcca
     1081 agatcacagc tatgatgccc tggttgccat ggcgatcttt ttcaacactc acaacgagcc
     1141 agtacggcag ctagccatct tctgtcccca cgaggcactt cgaatgacaa tctgtggagt
     1201 cctggaacag tccacctccc cagccctgaa gctgacaccc atcccgagca tctctgctca
     1261 cctccaggcc tatcttcaag gcaacaccca ggtctctcga aagaagctgc tgcctgtgct
     1321 gcaggaagcg ctctctgcat atctcgactc catgaggacg cctgcagggc agctggaggc
     1381 cgccttgggt atgtctaggg agcaggctga caaggagttg gacaaggcga gtaactccct
     1441 gatcgctgga ctgagtcaag atgatgaaga ccctcctctg ccgcccacgc ccatgaacag
     1501 cttggtggat gagtgccccc tggatcaggg gctgcctaag ctctctgccg aggctgtctt
     1561 tgagaagtgc agtcagatct cactatccca gtctaccaga gcctgcccat caaataagtg
     1621 accatcggag gcggggtcgg ggagtgtgga ggtggtagtg actggcccgc ctcaaatgca
     1681 tgttttgaga tgtttgaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
