LOCUS       NM_001024264             972 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus proteinase 3 (Prtn3), mRNA.
ACCESSION   NM_001024264 XM_234882
VERSION     NM_001024264.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 972)
  AUTHORS   Jerke,U., Marino,S.F., Daumke,O. and Kettritz,R.
  TITLE     Characterization of the CD177 interaction with the ANCA antigen
            proteinase 3
  JOURNAL   Sci Rep 7, 43328 (2017)
   PUBMED   28240246
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 972)
  AUTHORS   Kuckleburg,C.J. and Newman,P.J.
  TITLE     Neutrophil proteinase 3 acts on protease-activated receptor-2 to
            enhance vascular endothelial cell barrier function
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (2), 275-284 (2013)
   PUBMED   23202369
REFERENCE   3  (bases 1 to 972)
  AUTHORS   Kuckleburg,C.J., Tilkens,S.B., Santoso,S. and Newman,P.J.
  TITLE     Proteinase 3 contributes to transendothelial migration of
            NB1-positive neutrophils
  JOURNAL   J Immunol 188 (5), 2419-2426 (2012)
   PUBMED   22266279
REFERENCE   4  (bases 1 to 972)
  AUTHORS   Kantari,C., Millet,A., Gabillet,J., Hajjar,E., Broemstrup,T.,
            Pluta,P., Reuter,N. and Witko-Sarsat,V.
  TITLE     Molecular analysis of the membrane insertion domain of proteinase
            3, the Wegener's autoantigen, in RBL cells: implication for its
            pathogenic activity
  JOURNAL   J Leukoc Biol 90 (5), 941-950 (2011)
   PUBMED   21821719
  REMARK    GeneRIF: role of the structural motifs of PR3 membrane anchorage in
            PR3 proinflammatory and proliferative functions
REFERENCE   5  (bases 1 to 972)
  AUTHORS   Jerke,U., Rolle,S., Dittmar,G., Bayat,B., Santoso,S., Sporbert,A.,
            Luft,F. and Kettritz,R.
  TITLE     Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated
            PR3-ANCA neutrophil activation
  JOURNAL   J Biol Chem 286 (9), 7070-7081 (2011)
   PUBMED   21193407
REFERENCE   6  (bases 1 to 972)
  AUTHORS   Kantari,C., Pederzoli-Ribeil,M., Amir-Moazami,O., Gausson-Dorey,V.,
            Moura,I.C., Lecomte,M.C., Benhamou,M. and Witko-Sarsat,V.
  TITLE     Proteinase 3, the Wegener autoantigen, is externalized during
            neutrophil apoptosis: evidence for a functional association with
            phospholipid scramblase 1 and interference with macrophage
            phagocytosis
  JOURNAL   Blood 110 (12), 4086-4095 (2007)
   PUBMED   17712045
REFERENCE   7  (bases 1 to 972)
  AUTHORS   von Vietinghoff,S., Tunnemann,G., Eulenberg,C., Wellner,M.,
            Cristina Cardoso,M., Luft,F.C. and Kettritz,R.
  TITLE     NB1 mediates surface expression of the ANCA antigen proteinase 3 on
            human neutrophils
  JOURNAL   Blood 109 (10), 4487-4493 (2007)
   PUBMED   17244676
REFERENCE   8  (bases 1 to 972)
  AUTHORS   Csernok,E., Ai,M., Gross,W.L., Wicklein,D., Petersen,A.,
            Lindner,B., Lamprecht,P., Holle,J.U. and Hellmich,B.
  TITLE     Wegener autoantigen induces maturation of dendritic cells and
            licenses them for Th1 priming via the protease-activated receptor-2
            pathway
  JOURNAL   Blood 107 (11), 4440-4448 (2006)
   PUBMED   16478888
REFERENCE   9  (bases 1 to 972)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   10 (bases 1 to 972)
  AUTHORS   Sorensen,O.E., Follin,P., Johnsen,A.H., Calafat,J., Tjabringa,G.S.,
            Hiemstra,P.S. and Borregaard,N.
  TITLE     Human cathelicidin, hCAP-18, is processed to the antimicrobial
            peptide LL-37 by extracellular cleavage with proteinase 3
  JOURNAL   Blood 97 (12), 3951-3959 (2001)
   PUBMED   11389039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 31, 2022 this sequence version replaced NM_001024264.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000007.1  10476119-10476196   c
            79-244              JAXUCZ010000007.1  10475293-10475458   c
            245-386             JAXUCZ010000007.1  10474600-10474741   c
            387-617             JAXUCZ010000007.1  10473643-10473873   c
            618-972             JAXUCZ010000007.1  10472750-10473104   c
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..972
                     /gene="Prtn3"
                     /note="proteinase 3"
                     /db_xref="GeneID:314615"
                     /db_xref="RGD:1304898"
     exon            1..78
                     /gene="Prtn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..776
                     /gene="Prtn3"
                     /EC_number="3.4.21.76"
                     /note="myeloblastin"
                     /codon_start=1
                     /product="myeloblastin precursor"
                     /protein_id="NP_001019435.1"
                     /db_xref="GeneID:314615"
                     /db_xref="RGD:1304898"
                     /translation="MAGIRPSLKGMHPFLLLALVFGGAVQASKIVGGHEARPHSRPYV
                     ASLQLSRSPGSHFCGGTLIHPRFVLTAAHCLQDISWQLVTVVLGAHDLLSSEPEQQKF
                     TITQVFENNYNPEETLNDVLLLQLNRPASLGKQVAVASLPQQDQSLSQGTQCLAMGWG
                     RLGTRAPTPRVLHELNVTVVTFLCREHNVCTLVPRRAAGICFGDSGGPLICNGILHGV
                     DSFVIRECASLQFPDFFARVSMYVNWIHSVLRSAEP"
     exon            79..244
                     /gene="Prtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            245..386
                     /gene="Prtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            387..617
                     /gene="Prtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            618..972
                     /gene="Prtn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcatggc catggctgga atccgcccat ccctcaaagg gatgcatccc ttcctgctgc
       61 ttgccctggt ctttggtggt gcagtccagg cctccaagat agtgggtggg cacgaggctc
      121 ggccccattc tcggccttat gtggcatccc tgcagctgag caggtcccct gggagccact
      181 tctgtggtgg cacgctgatc cacccgagat tcgtgctgac agctgcccac tgcctgcagg
      241 acatctcctg gcagcttgtg acagtggtgc tgggtgccca cgacctgctg agctcggagc
      301 ctgagcagca gaagttcact atcactcagg tcttcgagaa caattacaac cccgaggaga
      361 ccctcaatga tgtgcttctc cttcagctaa accggccggc ctccctgggc aagcaggtgg
      421 cggtggcctc tctgccccag caggaccagt ctctctccca gggcacccaa tgcctggcta
      481 tgggctgggg ccgcctgggc acccgagcgc ccacgccccg tgtgctgcat gaactgaacg
      541 tcacggtggt caccttcctg tgccgagaac acaacgtgtg cacgctggtg ccacggaggg
      601 cagcaggcat ttgcttcgga gactcgggcg gccccttgat ctgcaacggc attcttcatg
      661 gagtggactc cttcgtgatt cgcgaatgcg cctccctcca gtttcccgat ttcttcgccc
      721 gggtgtccat gtatgtgaac tggattcaca gtgtgctgcg gagcgcagag ccctgaggtg
      781 cccttctgtg ctccgggcag cctaaaactg gggcgaccac tagcagactc cagtggggaa
      841 aacgtggagt gaagtagact ggtcctttct aggcttttct gccatccacc cacccacgga
      901 cccgctggaa tggagtcagt tctgttctcc aattccatgc gacctcaata aaaactgaga
      961 tatatttaaa aa
//
