LOCUS       NM_001009174             952 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus serine protease 58 (Prss58), mRNA.
ACCESSION   NM_001009174 XM_017592739 XM_579279
VERSION     NM_001009174.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   Lindkvist,B., Wierup,N., Sundler,F. and Borgstrom,A.
  TITLE     Long-term nicotine exposure causes increased concentrations of
            trypsinogens and amylase in pancreatic extracts in the rat
  JOURNAL   Pancreas 37 (3), 288-294 (2008)
   PUBMED   18815551
  REMARK    GeneRIF: Nicotine impairs secretion rather than production of
            pancreatic trypsinogen 1.
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Oct 7, 2022 this sequence version replaced
            XM_017592739.2, NM_001009174.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1750220.1,
                                           SRR26360186.885353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000004.1  70723555-70723647   c
            94-175              JAXUCZ010000004.1  70723337-70723418   c
            176-314             JAXUCZ010000004.1  70721779-70721917   c
            315-571             JAXUCZ010000004.1  70721325-70721581   c
            572-711             JAXUCZ010000004.1  70719650-70719789   c
            712-952             JAXUCZ010000004.1  70719326-70719566   c
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..952
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /note="serine protease 58"
                     /db_xref="GeneID:408204"
                     /db_xref="RGD:1303054"
     exon            1..93
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     exon            94..175
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..861
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /EC_number="3.4.21.4"
                     /function="serine protease"
                     /note="putative trypsin-X3; putative inactive serine
                     protease 58; protease, serine, 58"
                     /codon_start=1
                     /product="putative inactive serine protease 58 precursor"
                     /protein_id="NP_001009174.1"
                     /db_xref="GeneID:408204"
                     /db_xref="RGD:1303054"
                     /translation="MKLVFCILSTLLGTFAYNPDHIAGTTPPYLVYLKSDYLPCTGVL
                     IHPLWVVTSAHCNLPDLRVILGITNPADTTEHDVEVSDYEKMFRHPYFSVSSISYDLM
                     LIKLRRGIKHSYYAKAVKLPQHTVPVNAMCSVSTWAYNLCDVTKEPDSLQTVNVSVIS
                     KAECHNAYKAFDIRENMICVGIVPGRRLPCKEVTAAPAVCNGVLYGILSYADGCVLRA
                     DVGIYASIFHYMPWIENIMKNN"
     exon            176..314
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..571
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..711
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..952
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaatcaaa gagcaggagg ctgtggagac attgtgaaca tctcacttgg attaagtaac
       61 ttcaagagaa gtcaaaatcc agctctagac agcagacact gagctaaact ccgtctcaaa
      121 ttagctttca acatcataat gaagttagtc ttctgcattc tttcaaccct gcttggtacc
      181 tttgcctata atccagatca catagctggc accactcccc cctacttagt ctacctgaag
      241 tctgattact tgccctgtac tggagtcctg atccatcctc tttgggtggt cacatctgca
      301 cactgcaatt taccggacct ccgggtgatt cttgggataa caaacccagc agataccaca
      361 gaacatgacg tggaggtgtc tgactatgag aaaatgttcc gtcatccata cttctcggtc
      421 tcttctattt catatgacct tatgttaatc aaactgagaa gagggattaa gcacagttac
      481 tatgcaaaag cagtcaagct acctcaacac actgtgcctg tgaatgccat gtgctctgtg
      541 tctacctggg cctacaatct atgtgacgtc accaaggaac ctgactcact gcagactgtg
      601 aacgtctctg taatctccaa ggctgagtgt cataatgcct ataaagcctt tgacatccga
      661 gaaaacatga tctgtgtggg catcgtgcca ggacggaggc tgccctgcaa ggaagtcacg
      721 gctgccccag cggtctgcaa tggggtactt tatggaatat tatcttatgc agatggctgc
      781 gttttgagag ctgatgttgg catctatgct agcatctttc actacatgcc ctggattgaa
      841 aatatcatga aaaataactg agctctcaca acaggaggaa ttctgaaaca tgtgacaaag
      901 catgtgccca catccaacct cacaattaaa tggaaccatg agaggcaccg cg
//
