LOCUS       NP_001009174             240 aa            linear   ROD 31-MAR-2024
DEFINITION  putative inactive serine protease 58 precursor [Rattus norvegicus].
ACCESSION   NP_001009174 XP_017448228 XP_579279
VERSION     NP_001009174.1
DBSOURCE    REFSEQ: accession NM_001009174.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 240)
  AUTHORS   Lindkvist,B., Wierup,N., Sundler,F. and Borgstrom,A.
  TITLE     Long-term nicotine exposure causes increased concentrations of
            trypsinogens and amylase in pancreatic extracts in the rat
  JOURNAL   Pancreas 37 (3), 288-294 (2008)
   PUBMED   18815551
  REMARK    GeneRIF: Nicotine impairs secretion rather than production of
            pancreatic trypsinogen 1.
REFERENCE   2  (residues 1 to 240)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Oct 7, 2022 this sequence version replaced
            XP_017448228.1, XP_579279.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1750220.1,
                                           SRR26360186.885353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..240
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     Protein         1..240
                     /product="putative inactive serine protease 58 precursor"
                     /EC_number="3.4.21.4"
                     /function="serine protease"
                     /note="putative trypsin-X3; putative inactive serine
                     protease 58; protease, serine, 58"
                     /calculated_mol_wt=25073
     sig_peptide     1..16
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1757
     mat_peptide     22..240
                     /product="putative inactive serine protease 58"
                     /calculated_mol_wt=24447
     Region          28..233
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            order(55,100,194)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            155
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6IE06.1)"
     Site            order(188,209,211)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..240
                     /gene="Prss58"
                     /gene_synonym="try1; Tryx3"
                     /coded_by="NM_001009174.2:139..861"
                     /db_xref="GeneID:408204"
                     /db_xref="RGD:1303054"
ORIGIN      
        1 mklvfcilst llgtfaynpd hiagttppyl vylksdylpc tgvlihplwv vtsahcnlpd
       61 lrvilgitnp adttehdvev sdyekmfrhp yfsvssisyd lmliklrrgi khsyyakavk
      121 lpqhtvpvna mcsvstwayn lcdvtkepds lqtvnvsvis kaechnayka fdirenmicv
      181 givpgrrlpc kevtaapavc ngvlygilsy adgcvlradv giyasifhym pwienimknn
//
