LOCUS       NM_001003956             887 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus serine protease 57 (Prss57), mRNA.
ACCESSION   NM_001003956 XM_579108
VERSION     NM_001003956.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Lin,S.J., Dong,K.C., Eigenbrot,C., van Lookeren Campagne,M. and
            Kirchhofer,D.
  TITLE     Structures of neutrophil serine protease 4 reveal an unusual
            mechanism of substrate recognition by a trypsin-fold protease
  JOURNAL   Structure 22 (9), 1333-1340 (2014)
   PUBMED   25156428
REFERENCE   2  (bases 1 to 887)
  AUTHORS   Perera,N.C., Wiesmuller,K.H., Larsen,M.T., Schacher,B.,
            Eickholz,P., Borregaard,N. and Jenne,D.E.
  TITLE     NSP4 is stored in azurophil granules and released by activated
            neutrophils as active endoprotease with restricted specificity
  JOURNAL   J Immunol 191 (5), 2700-2707 (2013)
   PUBMED   23904161
REFERENCE   3  (bases 1 to 887)
  AUTHORS   Perera,N.C., Schilling,O., Kittel,H., Back,W., Kremmer,E. and
            Jenne,D.E.
  TITLE     NSP4, an elastase-related protease in human neutrophils with
            arginine specificity
  JOURNAL   Proc Natl Acad Sci U S A 109 (16), 6229-6234 (2012)
   PUBMED   22474388
REFERENCE   4  (bases 1 to 887)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 13, 2022 this sequence version replaced NM_001003956.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN000334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680424
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000007.1  10568091-10568209
            120-273             JAXUCZ010000007.1  10569724-10569877
            274-418             JAXUCZ010000007.1  10571253-10571397
            419-682             JAXUCZ010000007.1  10572531-10572794
            683-887             JAXUCZ010000007.1  10573413-10573617
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..887
                     /gene="Prss57"
                     /gene_synonym="Df2; NSP4; Prssl1"
                     /note="serine protease 57"
                     /db_xref="GeneID:408241"
                     /db_xref="RGD:1303330"
     exon            1..119
                     /gene="Prss57"
                     /gene_synonym="Df2; NSP4; Prssl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..742
                     /gene="Prss57"
                     /gene_synonym="Df2; NSP4; Prssl1"
                     /function="serine protease"
                     /note="serine protease 1-like protein 1; PRSSL1 homolog;
                     complement factor D-like protein; protease, serine-like 1;
                     neutrophil serine protease 4; protease, serine, 57"
                     /codon_start=1
                     /product="serine protease 57 precursor"
                     /protein_id="NP_001003956.1"
                     /db_xref="GeneID:408241"
                     /db_xref="RGD:1303330"
                     /translation="MVPGTGGGRDCLTLVVATALTQLLWLPGCCGSHIVGGHEVKPHA
                     RPYMASVNFEGHHHCGGFLFHAHWVLSAAHCFSDRDPSTGLVVLGAHALLTPEPTQQV
                     FGIAAVVSHPDFEPTTQANDICLLRLNGSAVLGPAVRLLRLPRRGAKPPVAGTRCRVS
                     GWGSVSDFEEPPPGLMEVEVRILDLSVCNSSWQGQLSPAMLCTHSGDRRRRGFCSASG
                     VVTPKLRMSTLKCQRL"
     exon            120..273
                     /gene="Prss57"
                     /gene_synonym="Df2; NSP4; Prssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..418
                     /gene="Prss57"
                     /gene_synonym="Df2; NSP4; Prssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..682
                     /gene="Prss57"
                     /gene_synonym="Df2; NSP4; Prssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..887
                     /gene="Prss57"
                     /gene_synonym="Df2; NSP4; Prssl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accttgacag gaagaggaga taccgtcctc cacagtcatg gtgcctggga caggaggagg
       61 ccgggactgc ctgacgctgg tcgtagcgac tgccctgacc cagctcctgt ggctccctgg
      121 ttgctgcgga tcccacattg ttggaggcca tgaggtgaag ccacatgccc ggccctacat
      181 ggcctctgtg aacttcgagg gccatcacca ttgtggaggc ttcttgttcc atgcccattg
      241 ggtgctgtca gctgcccatt gcttcagtga cagggacccc tccactggcc tggtggtgct
      301 tggggcccat gccctgctca ccccggagcc cacacaacag gtatttggca ttgcggctgt
      361 tgtcagccat cctgattttg agccgaccac acaggccaat gacatctgcc tgctaaggct
      421 gaatggctct gctgtgctgg gccccgctgt gaggctattg cgactgcctc ggagaggagc
      481 taagcctccc gtggcgggca cccggtgccg cgtatctggc tggggctccg tgtctgactt
      541 tgaggagcct ccacctgggc tgatggaagt cgaggtgcgc atactagacc tgagcgtctg
      601 caacagctcc tggcagggcc agctgagtcc tgccatgctc tgtacccaca gtggggaccg
      661 ccggcggcgt ggtttctgct cggcctctgg tgtggtgacc ccaaaactcc ggatgtctac
      721 actcaagtgt cagcgtttgt gagctggatc tgggatgtgg ttcgagcaag tccaaccccc
      781 ggttcaatgg gatgctcttt gagggctgtt tgagtctcag ccccctactg gggcagaaat
      841 gaatgacaac cagtgcccgt tggctcacat ctggaatatt ccctgac
//
