LOCUS       NM_173127                821 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus protease, serine, 3B (Prss3b), mRNA.
ACCESSION   NM_173127
VERSION     NM_173127.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 821)
  AUTHORS   Jiang,C., Zheng,H., Liu,S. and Fang,K.
  TITLE     Relationship between carbachol hyperstimulation-induced pancreatic
            intracellular trypsinogen and NF-kappa B activation in rats in
            vitro
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 28 (1), 69-72 (2008)
   PUBMED   18278461
  REMARK    GeneRIF: NF-kappa B activation is likely not necessary for high
            concentrations of carbachol-induced trypsinogen activation in
            pancreatic acinar cells in vitro
REFERENCE   2  (bases 1 to 821)
  AUTHORS   Gaiser,S., Ahler,A., Gundling,F., Kruse,M.L., Savkovic,V.,
            Selig,L., Teich,N., Tomasini,R., Dagorn,J.C., Mossner,J., Keim,V.
            and Bodeker,H.
  TITLE     Expression of mutated cationic trypsinogen reduces cellular
            viability in AR4-2J cells
  JOURNAL   Biochem Biophys Res Commun 334 (2), 721-728 (2005)
   PUBMED   16036133
  REMARK    GeneRIF: Expression of trypsin and R122H trypsinogen induced
            caspase-3 activity. Acinar cells might react to intracellular
            trypsin activity by triggering apoptosis.
REFERENCE   3  (bases 1 to 821)
  AUTHORS   Wang,S., He,R. and Anderson,R.
  TITLE     PrM- and cell-binding domains of the dengue virus E protein
  JOURNAL   J Virol 73 (3), 2547-2551 (1999)
   PUBMED   9971841
REFERENCE   4  (bases 1 to 821)
  AUTHORS   Roach,J.C., Wang,K., Gan,L. and Hood,L.
  TITLE     The molecular evolution of the vertebrate trypsinogens
  JOURNAL   J Mol Evol 45 (6), 640-652 (1997)
   PUBMED   9419241
  REMARK    GeneRIF: This trypsinogen is typical of non-human gnathostomata
            trypinsogens; it has 6 predicted cystine bridges and an acidic
            activation peptide. It clusters with group II ('cationic')
            trypsins.
REFERENCE   5  (bases 1 to 821)
  AUTHORS   Fletcher,T.S., Alhadeff,M., Craik,C.S. and Largman,C.
  TITLE     Isolation and characterization of a cDNA encoding rat cationic
            trypsinogen
  JOURNAL   Biochemistry 26 (11), 3081-3086 (1987)
   PUBMED   3607011
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M16624.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16624.1, FQ226997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..821
                     /gene="Prss3b"
                     /gene_synonym="Prss3; Try3"
                     /note="protease, serine, 3B"
                     /db_xref="GeneID:286911"
                     /db_xref="RGD:708437"
     CDS             1..744
                     /gene="Prss3b"
                     /gene_synonym="Prss3; Try3"
                     /EC_number="3.4.21.4"
                     /note="cationic trypsin-3; pretrypsinogen III; cationic
                     trypsin III; cationic trypsinogen; protease, serine, 3"
                     /codon_start=1
                     /product="cationic trypsin-3 precursor"
                     /protein_id="NP_775150.1"
                     /db_xref="GeneID:286911"
                     /db_xref="RGD:708437"
                     /translation="MKALIFLAFLGAAVALPLDDDDDKIVGGYTCQKNSLPYQVSLNA
                     GYHFCGGSLINSQWVVSAAHCYKSRIQVRLGEHNIDVVEGGEQFIDAAKIIRHPSYNA
                     NTFDNDIMLIKLNSPATLNSRVSTVSLPRSCGSSGTKCLVSGWGNTLSSGTNYPSLLQ
                     CLDAPVLSDSSCKSSYPGKITSNMFCLGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG
                     YGCAQKGKPGVYTKVCNYVNWIQQTVAAN"
     exon            1..40
                     /gene="Prss3b"
                     /gene_synonym="Prss3; Try3"
                     /inference="alignment:Splign:2.1.0"
     exon            41..203
                     /gene="Prss3b"
                     /gene_synonym="Prss3; Try3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..457
                     /gene="Prss3b"
                     /gene_synonym="Prss3; Try3"
                     /inference="alignment:Splign:2.1.0"
     exon            458..594
                     /gene="Prss3b"
                     /gene_synonym="Prss3; Try3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..820
                     /gene="Prss3b"
                     /gene_synonym="Prss3; Try3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaggcct taattttcct tgctttcctt ggagctgctg ttgctctccc tctggatgat
       61 gatgatgaca agattgttgg aggctacacc tgccagaaga attctctccc ataccaggtg
      121 tctctgaatg ctggctacca tttttgtgga ggctccctca tcaattccca gtgggttgtt
      181 tcagccgctc actgctacaa atcccgaatt caggtgcgcc tgggagaaca caacattgat
      241 gtcgttgagg gtggtgagca attcattgat gcagctaaaa tcatccgcca ccccagttat
      301 aatgcaaaca cctttgacaa tgatattatg ttgattaagc tgaattcacc tgccaccctc
      361 aattctcgag tgtccactgt ctctctgcca agatcttgtg gatcatctgg tactaagtgc
      421 cttgtgtctg gctggggcaa caccctgagc tctggcacga actacccttc actgcttcag
      481 tgtcttgatg cccctgtcct ctctgacagt tcttgcaaaa gttcttaccc aggcaagatc
      541 actagcaaca tgttctgtct gggctttctg gagggcggaa aggactcctg ccagggtgac
      601 tctggtggcc ctgtagtctg caatggccag ctccagggtg ttgtttcctg gggttatggc
      661 tgtgctcaga aaggaaaacc tggtgtctat accaaggtat gcaactacgt gaactggatt
      721 cagcagaccg tcgctgccaa ctaaaacgcc tttatgtctt tatactttgt agtcaaatcc
      781 accttctttg tatgccccaa gtcattctca caagaaaaac a
//
