LOCUS       NM_001108626             811 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus serine protease 3 (Prss3), mRNA.
ACCESSION   NM_001108626 XM_001068100 XM_342668
VERSION     NM_001108626.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 811)
  AUTHORS   Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skaregarde A, Gedda K,
            Peterson A, Chapman K, Hollenberg MD, Vergnolle N and Bunnett NW.
  TITLE     Trypsin IV or mesotrypsin and p23 cleave protease-activated
            receptors 1 and 2 to induce inflammation and hyperalgesia
  JOURNAL   J Biol Chem 282 (36), 26089-26100 (2007)
   PUBMED   17623652
  REMARK    GeneRIF: trypsin IV and p23 are inhibitor-resistant trypsins that
            can cleave and activate PARs, causing PAR(1)- and PAR(2)-dependent
            inflammation and PAR(2)-dependent hyperalgesia.
REFERENCE   2  (bases 1 to 811)
  AUTHORS   Wang Y, Luo W, Wartmann T, Halangk W, Sahin-Toth M and Reiser G.
  TITLE     Mesotrypsin, a brain trypsin, activates selectively
            proteinase-activated receptor-1, but not proteinase-activated
            receptor-2, in rat astrocytes
  JOURNAL   J Neurochem 99 (3), 759-769 (2006)
   PUBMED   16903872
  REMARK    GeneRIF: brain-specific mesotrypsin, via the regulation of PAR-1,
            is likely to be involved in multiple physiological/pathological
            processes in the brain
REFERENCE   3  (bases 1 to 811)
  AUTHORS   Diederichs S, Bulk E, Steffen B, Ji P, Tickenbrock L, Lang K,
            Zanker KS, Metzger R, Schneider PM, Gerke V, Thomas M, Berdel WE,
            Serve H and Muller-Tidow C.
  TITLE     S100 family members and trypsinogens are predictors of distant
            metastasis and survival in early-stage non-small cell lung cancer
  JOURNAL   Cancer Res 64 (16), 5564-5569 (2004)
   PUBMED   15313892
REFERENCE   4  (bases 1 to 811)
  AUTHORS   Szmola R, Kukor Z and Sahin-Toth M.
  TITLE     Human mesotrypsin is a unique digestive protease specialized for
            the degradation of trypsin inhibitors
  JOURNAL   J Biol Chem 278 (49), 48580-48589 (2003)
   PUBMED   14507909
REFERENCE   5  (bases 1 to 811)
  AUTHORS   Katona G, Berglund GI, Hajdu J, Graf L and Szilagyi L.
  TITLE     Crystal structure reveals basis for the inhibitor resistance of
            human brain trypsin
  JOURNAL   J Mol Biol 315 (5), 1209-1218 (2002)
   PUBMED   11827488
REFERENCE   6  (bases 1 to 811)
  AUTHORS   Nyaruhucha CN, Kito M and Fukuoka SI.
  TITLE     Identification and expression of the cDNA-encoding human
            mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance
  JOURNAL   J Biol Chem 272 (16), 10573-10578 (1997)
   PUBMED   9099703
REFERENCE   7  (bases 1 to 811)
  AUTHORS   Rinderknecht,H., Renner,I.G., Abramson,S.B. and Carmack,C.
  TITLE     Mesotrypsin: a new inhibitor-resistant protease from a zymogen in
            human pancreatic tissue and fluid
  JOURNAL   Gastroenterology 86 (4), 681-692 (1984)
   PUBMED   6698368
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068100.1, XM_342668.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231537.1, CF249023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..811
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..811
                     /gene="Prss3"
                     /gene_synonym="Try4"
                     /note="serine protease 3"
                     /db_xref="GeneID:362347"
                     /db_xref="RGD:1311446"
     exon            1..57
                     /gene="Prss3"
                     /gene_synonym="Try4"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..758
                     /gene="Prss3"
                     /gene_synonym="Try4"
                     /note="trypsin 4; protease, serine 3; protease, serine, 3
                     (mesotrypsin)"
                     /codon_start=1
                     /product="serine protease 3 precursor"
                     /protein_id="NP_001102096.1"
                     /db_xref="GeneID:362347"
                     /db_xref="RGD:1311446"
                     /translation="MRALLFLALVGVAVAFPVDDDDKIVGGYTCQENSVPYQVSLNSG
                     YHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNINVLEGDEQFVNAAKIIKHPNFNAR
                     NLNNDIMLIKLSSPVKLNARVATVALPSSCAPAGTQCLISGWGNTLSLGVNNPDLLQC
                     LDAPVLPQADCEASYPGKITNNMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGY
                     GCALKDNPGVYTKVCNYVDWIQDTIAAN"
     exon            58..217
                     /gene="Prss3"
                     /gene_synonym="Try4"
                     /inference="alignment:Splign:2.1.0"
     exon            218..471
                     /gene="Prss3"
                     /gene_synonym="Try4"
                     /inference="alignment:Splign:2.1.0"
     exon            472..608
                     /gene="Prss3"
                     /gene_synonym="Try4"
                     /inference="alignment:Splign:2.1.0"
     exon            609..811
                     /gene="Prss3"
                     /gene_synonym="Try4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctaccttt tgccaaaatg agagcactcc tgttcctggc ccttgtggga gttgctgttg
       61 ctttccctgt ggatgacgat gacaagatag ttggaggata cacctgccaa gagaattctg
      121 tcccctacca ggtgtccctg aactctggct accacttctg tggaggttcc ctcatcaacg
      181 accagtgggt ggtgtctgca gctcactgtt acaagacccg catccaagtg agactcggag
      241 agcacaacat caatgtcctt gagggcgatg agcagtttgt caatgctgcc aagatcatca
      301 agcatcccaa ctttaatgca aggaacctga acaatgacat catgctgatc aagctctctt
      361 cccctgtgaa actcaatgct cgagtggcca ctgtggctct gcccagctcc tgtgcacctg
      421 caggcactca gtgcctcatc tctggctggg gcaacaccct cagtcttggt gtgaacaacc
      481 cagacctgct ccagtgcctg gatgccccag tgctgcctca ggctgactgt gaggcctcct
      541 accctggaaa gatcaccaat aacatgatct gtgttggctt cctggaggga ggcaaagatt
      601 cctgccaggg tgactctggt ggccctgtgg tctgcaatgg acagctccag ggcattgtct
      661 cctggggcta tggctgtgcc ctgaaggaca accctggtgt gtacaccaag gtctgcaact
      721 atgtggactg gattcaggac accattgctg caaactaagt ttcctaaatc tccttgaagt
      781 cactgtgcca gtaaagttga ttttttccat t
//
