LOCUS       NM_181477               1139 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus serine protease 21 (Prss21), mRNA.
ACCESSION   NM_181477
VERSION     NM_181477.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   Asano,A., Nelson-Harrington,J.L. and Travis,A.J.
  TITLE     Phospholipase B is activated in response to sterol removal and
            stimulates acrosome exocytosis in murine sperm
  JOURNAL   J Biol Chem 288 (39), 28104-28115 (2013)
   PUBMED   23943622
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Nakamura,Y., Inoue,M., Okumura,Y., Shiota,M., Nishikawa,M.,
            Arase,S. and Kido,H.
  TITLE     Cloning, expression analysis, and tissue distribution of
            esp-1/testisin, a membrane-type serine protease from the rat
  JOURNAL   J Med Invest 50 (1-2), 78-86 (2003)
   PUBMED   12630572
  REMARK    GeneRIF: a role in species-specific proteolytic events during
            spermatogenesis and fertilization
            GeneRIF: Esp-1/Testisin plays a role in species-specific
            proteolytic events during spermatogenesis and fertilization.
REFERENCE   3  (bases 1 to 1139)
  AUTHORS   Honda,A., Yamagata,K., Sugiura,S., Watanabe,K. and Baba,T.
  TITLE     A mouse serine protease TESP5 is selectively included into lipid
            rafts of sperm membrane presumably as a
            glycosylphosphatidylinositol-anchored protein
  JOURNAL   J Biol Chem 277 (19), 16976-16984 (2002)
   PUBMED   11861648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 8, 2021 this sequence version replaced NM_181477.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB074516.1, SRR26643293.61745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000010.1  13405066-13405243
            179-205             JAXUCZ010000010.1  13405345-13405371
            206-371             JAXUCZ010000010.1  13405648-13405813
            372-655             JAXUCZ010000010.1  13406265-13406548
            656-810             JAXUCZ010000010.1  13409430-13409584
            811-1139            JAXUCZ010000010.1  13409867-13410195
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1139
                     /gene="Prss21"
                     /gene_synonym="Esp-1; Resp-1"
                     /note="serine protease 21"
                     /db_xref="GeneID:353251"
                     /db_xref="RGD:727870"
     exon            1..178
                     /gene="Prss21"
                     /gene_synonym="Esp-1; Resp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1053
                     /gene="Prss21"
                     /gene_synonym="Esp-1; Resp-1"
                     /note="eosinophil serine protease-1; testisin; protease,
                     serine, 21"
                     /codon_start=1
                     /product="serine protease 21 precursor"
                     /protein_id="NP_852142.1"
                     /db_xref="GeneID:353251"
                     /db_xref="RGD:727870"
                     /translation="MSARGKTLVPLLVVVVAVEVTLQSTSSHVKPVDPEKPELQEANL
                     LSGPCGHRTIPSRIVGGEEAELGRWPWQGSLRVWGNHLCGATLLNRRWVLTAAHCFQK
                     DNDPFDWTVQFGELTSRPSLWNLQAYSNRYQIEDIFLSPKYTEQFPHDIALLKLSSPV
                     TYSNFIQPICLLNSTYKFANRTDCWVTGWGAIGEDESLPLPNNLQEVQVAIINNTMCN
                     HLFKKPDFRINIWGDMVCAGSPEGGKDACFGDSGGPLVCNQDTVWYQVGVVSWGIGCG
                     RPNRPGVYTNISHHYNWIRLTMIRNGMLRPDPAPLLLFLTLAWASSSLLRPA"
     exon            179..205
                     /gene="Prss21"
                     /gene_synonym="Esp-1; Resp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..371
                     /gene="Prss21"
                     /gene_synonym="Esp-1; Resp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..655
                     /gene="Prss21"
                     /gene_synonym="Esp-1; Resp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..810
                     /gene="Prss21"
                     /gene_synonym="Esp-1; Resp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1139
                     /gene="Prss21"
                     /gene_synonym="Esp-1; Resp-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagagggc gcgggcctgg cgtagcagga agtaagaggg ggcgccaggt ggccggagag
       61 gtggccatga gcgcgcgggg caagacgttg gtgccactgc tggtggttgt ggtggcggtg
      121 gaggtgacct tacagtcaac ctcttcgcat gtgaaacccg tggatcccga gaaacccgaa
      181 ctgcaggaag ccaacctatt gtcaggaccc tgcggtcaca ggaccatccc ttcacgtata
      241 gtgggtggcg aagaggccga gcttggccgc tggccttggc aagggagcct gcgtgtatgg
      301 ggcaaccact tatgtggcgc aactttgctc aaccgccgct gggtgcttac agctgcccac
      361 tgcttccaaa aggacaatga tcctttcgac tggacagtcc agtttggcga gctgacctcc
      421 aggccgtctc tctggaacct acaggcttat tccaaccgtt accaaataga agatattttc
      481 ctgagcccca agtacacgga gcagtttccc catgacatag ctctgctgaa gctgtcatcg
      541 cctgtcacct acagtaactt catccagccc atctgcctcc tgaactccac atacaagttt
      601 gcgaaccgaa ctgactgctg ggtgaccggc tggggggcta ttggagagga tgagagtctg
      661 ccacttccca acaacctcca ggaagtgcag gtagctatca tcaacaacac catgtgtaac
      721 catttgttca aaaagccaga cttccgaata aacatctggg gagacatggt ttgcgctggc
      781 agtcctgaag gcggcaagga tgcctgcttt ggtgactcag gaggaccctt ggtctgcaac
      841 caggatacag tgtggtatca ggtcggagtt gtgagctggg gaataggctg tggtcggccc
      901 aatcgccctg gagtctatac caacatcagt catcactaca actggatccg gttgactatg
      961 atccgaaacg ggatgctcag gcctgaccca gcccccctac tgctgtttct tactctggcc
     1021 tgggcttctt cctctctgct gaggcctgcc tgagccttcg tgtgtaaagc agggcacctg
     1081 tggggtcagg ctgtttcttt tgtatctcgt ttgctaataa acacattgat agtttccta
//
