LOCUS       NM_012729                796 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protease, serine, 2 (Prss2), mRNA.
ACCESSION   NM_012729
VERSION     NM_012729.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 796)
  AUTHORS   Nikolakopoulou,A.M., Dutta,R., Chen,Z., Miller,R.H. and Trapp,B.D.
  TITLE     Activated microglia enhance neurogenesis via trypsinogen secretion
  JOURNAL   Proc Natl Acad Sci U S A 110 (21), 8714-8719 (2013)
   PUBMED   23650361
  REMARK    GeneRIF: activated microglia increase neurogenesis through
            secretion of PRSS2.
REFERENCE   2  (bases 1 to 796)
  AUTHORS   Lindkvist,B., Wierup,N., Sundler,F. and Borgstrom,A.
  TITLE     Long-term nicotine exposure causes increased concentrations of
            trypsinogens and amylase in pancreatic extracts in the rat
  JOURNAL   Pancreas 37 (3), 288-294 (2008)
   PUBMED   18815551
  REMARK    GeneRIF: Nicotine impairs secretion rather than production of
            pancreatic trypsinogen 2.
REFERENCE   3  (bases 1 to 796)
  AUTHORS   Lucas,J.M., True,L., Hawley,S., Matsumura,M., Morrissey,C.,
            Vessella,R. and Nelson,P.S.
  TITLE     The androgen-regulated type II serine protease TMPRSS2 is
            differentially expressed and mislocalized in prostate
            adenocarcinoma
  JOURNAL   J Pathol 215 (2), 118-125 (2008)
   PUBMED   18338334
REFERENCE   4  (bases 1 to 796)
  AUTHORS   Lauhio,A., Sorsa,T., Srinivas,R., Stenman,M., Tervahartiala,T.,
            Stenman,U.H., Gronhagen-Riska,C. and Honkanen,E.
  TITLE     Urinary matrix metalloproteinase -8, -9, -14 and their regulators
            (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy
  JOURNAL   Ann Med 40 (4), 312-320 (2008)
   PUBMED   18428024
REFERENCE   5  (bases 1 to 796)
  AUTHORS   Ye,S., Cech,A.L., Belmares,R., Bergstrom,R.C., Tong,Y., Corey,D.R.,
            Kanost,M.R. and Goldsmith,E.J.
  TITLE     The structure of a Michaelis serpin-protease complex
  JOURNAL   Nat Struct Biol 8 (11), 979-983 (2001)
   PUBMED   11685246
REFERENCE   6  (bases 1 to 796)
  AUTHORS   Earnest,T., Fauman,E., Craik,C.S. and Stroud,R.
  TITLE     1.59 A structure of trypsin at 120 K: comparison of low temperature
            and room temperature structures
  JOURNAL   Proteins 10 (3), 171-187 (1991)
   PUBMED   1881877
REFERENCE   7  (bases 1 to 796)
  AUTHORS   Dakka,N., Puigserver,A. and Wicker,C.
  TITLE     Regulation by a protein-free carbohydrate-rich diet of rat
            pancreatic mRNAs encoding trypsin and elastase isoenzymes
  JOURNAL   Biochem J 268 (2), 471-474 (1990)
   PUBMED   2363685
REFERENCE   8  (bases 1 to 796)
  AUTHORS   Sprang,S., Standing,T., Fletterick,R.J., Stroud,R.M.,
            Finer-Moore,J., Xuong,N.H., Hamlin,R., Rutter,W.J. and Craik,C.S.
  TITLE     The three-dimensional structure of Asn102 mutant of trypsin: role
            of Asp102 in serine protease catalysis
  JOURNAL   Science 237 (4817), 905-909 (1987)
   PUBMED   3112942
REFERENCE   9  (bases 1 to 796)
  AUTHORS   Craik,C.S., Choo,Q.L., Swift,G.H., Quinto,C., MacDonald,R.J. and
            Rutter,W.J.
  TITLE     Structure of two related rat pancreatic trypsin genes
  JOURNAL   J Biol Chem 259 (22), 14255-14264 (1984)
   PUBMED   6094547
REFERENCE   10 (bases 1 to 796)
  AUTHORS   MacDonald,R.J., Stary,S.J. and Swift,G.H.
  TITLE     Two similar but nonallelic rat pancreatic trypsinogens. Nucleotide
            sequences of the cloned cDNAs
  JOURNAL   J Biol Chem 257 (16), 9724-9732 (1982)
   PUBMED   6896710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Apr 13, 2016 this sequence version replaced NM_012729.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: V01274.1, CF249477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN06680431 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000004.1  71244964-71245003
            41-200              JAXUCZ010000004.1  71247420-71247579
            201-454             JAXUCZ010000004.1  71248790-71249043
            455-591             JAXUCZ010000004.1  71249448-71249584
            592-796             JAXUCZ010000004.1  71249839-71250043
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..796
                     /gene="Prss2"
                     /gene_synonym="Ptryss2"
                     /note="protease, serine, 2"
                     /db_xref="GeneID:25052"
                     /db_xref="RGD:3418"
     CDS             1..741
                     /gene="Prss2"
                     /gene_synonym="Ptryss2"
                     /EC_number="3.4.21.4"
                     /note="anionic trypsin-2; pancreatic trypsin II;
                     pretrypsinogen II; serine protease 2; anionic trypsin II;
                     pancreatic trypsin 2"
                     /codon_start=1
                     /product="anionic trypsin-2 precursor"
                     /protein_id="NP_036861.1"
                     /db_xref="GeneID:25052"
                     /db_xref="RGD:3418"
                     /translation="MRALLFLALVGAAVAFPVDDDDKIVGGYTCQENSVPYQVSLNSG
                     YHFCGGSLINDQWVVSAAHCYKSRIQVRLGEHNINVLEGNEQFVNAAKIIKHPNFDRK
                     TLNNDIMLIKLSSPVKLNARVATVALPSSCAPAGTQCLISGWGNTLSSGVNEPDLLQC
                     LDAPLLPQADCEASYPGKITDNMVCVGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGY
                     GCALPDNPGVYTKVCNYVDWIQDTIAAN"
     exon            1..40
                     /gene="Prss2"
                     /gene_synonym="Ptryss2"
                     /inference="alignment:Splign:2.1.0"
     exon            41..200
                     /gene="Prss2"
                     /gene_synonym="Ptryss2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..454
                     /gene="Prss2"
                     /gene_synonym="Ptryss2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..591
                     /gene="Prss2"
                     /gene_synonym="Ptryss2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..796
                     /gene="Prss2"
                     /gene_synonym="Ptryss2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagagcac tcctgttcct ggctcttgtg ggagctgctg ttgcttttcc cgtggatgat
       61 gatgacaaga tcgttggagg atacacctgc caagagaatt ctgttcccta ccaagtgtcc
      121 ctgaactctg gctaccactt ctgtggaggt tccctcatca atgaccagtg ggtggtgtct
      181 gcagctcact gctataagtc ccgcatccaa gtgagactgg gagagcacaa catcaatgtc
      241 cttgagggca atgagcagtt tgtcaatgct gccaagatca tcaagcatcc caacttcgat
      301 aggaagaccc tgaacaatga catcatgctg atcaagctct cttcccctgt gaaactcaat
      361 gctcgagtgg ccactgtggc tcttcccagc tcctgtgcac ctgcaggcac tcagtgcctc
      421 atctctggct ggggcaacac gctcagcagt ggcgtcaatg aaccagacct gctccagtgc
      481 ctggatgccc cactgctgcc ccaagctgac tgtgaagcct cctaccctgg aaagatcact
      541 gacaacatgg tctgtgttgg cttcctagag ggaggcaagg attcctgcca gggtgactct
      601 ggtggccctg tggtctgtaa tggagagctg cagggcattg tctcctgggg ctatggctgt
      661 gccctgccag ataaccctgg tgtgtacacc aaggtctgca actatgtgga ctggattcag
      721 gacacaattg ctgccaacta gagctctcca atccctctac agtcattatg tcaataaagt
      781 gaaatattct ttactg
//
