LOCUS       NM_012635                804 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine protease 1 (Prss1), mRNA.
ACCESSION   NM_012635
VERSION     NM_012635.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 804)
  AUTHORS   Yang,H., Zhang,H., Chen,Z., Wang,Y. and Gao,B.
  TITLE     Effects of tRNA-derived fragments and microRNAs regulatory network
            on pancreatic acinar intracellular trypsinogen activation
  JOURNAL   Bioengineered 13 (2), 3207-3220 (2022)
   PUBMED   35045793
  REMARK    GeneRIF: Effects of tRNA-derived fragments and microRNAs regulatory
            network on pancreatic acinar intracellular trypsinogen activation.
REFERENCE   2  (bases 1 to 804)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   3  (bases 1 to 804)
  AUTHORS   Chang,M., Alsaigh,T., Kistler,E.B. and Schmid-Schonbein,G.W.
  TITLE     Breakdown of mucin as barrier to digestive enzymes in the ischemic
            rat small intestine
  JOURNAL   PLoS One 7 (6), e40087 (2012)
   PUBMED   22768227
  REMARK    GeneRIF: These results indicate that mucin plays an important role
            in the preservation of the mucosal barrier and that ischemia but
            not digestive enzymes disturbs mucin integrity, while digestive
            enzymes actively mediate epithelial cell disruption.
REFERENCE   4  (bases 1 to 804)
  AUTHORS   Lauhio,A., Sorsa,T., Srinivas,R., Stenman,M., Tervahartiala,T.,
            Stenman,U.H., Gronhagen-Riska,C. and Honkanen,E.
  TITLE     Urinary matrix metalloproteinase -8, -9, -14 and their regulators
            (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy
  JOURNAL   Ann Med 40 (4), 312-320 (2008)
   PUBMED   18428024
REFERENCE   5  (bases 1 to 804)
  AUTHORS   Towatari,T., Ide,M., Ohba,K., Chiba,Y., Murakami,M., Shiota,M.,
            Kawachi,M., Yamada,H. and Kido,H.
  TITLE     Identification of ectopic anionic trypsin I in rat lungs
            potentiating pneumotropic virus infectivity and increased enzyme
            level after virus infection
  JOURNAL   Eur J Biochem 269 (10), 2613-2621 (2002)
   PUBMED   12027901
  REMARK    GeneRIF: ectopic anionic trypsin I in rat lungs induced by virus
            infection may trigger virus spread in rat lungs
REFERENCE   6  (bases 1 to 804)
  AUTHORS   Dakka,N., Puigserver,A. and Wicker,C.
  TITLE     Regulation by a protein-free carbohydrate-rich diet of rat
            pancreatic mRNAs encoding trypsin and elastase isoenzymes
  JOURNAL   Biochem J 268 (2), 471-474 (1990)
   PUBMED   2363685
REFERENCE   7  (bases 1 to 804)
  AUTHORS   Dubick,M.A. and Majumdar,A.P.
  TITLE     Biochemical changes in the exocrine pancreas of rats fed caffeine
  JOURNAL   Proc Soc Exp Biol Med 191 (2), 153-158 (1989)
   PUBMED   2726780
REFERENCE   8  (bases 1 to 804)
  AUTHORS   Dubick,M.A., Palmer,R., Lau,P.P., Morrill,P.R. and Geokas,M.C.
  TITLE     Altered exocrine pancreatic function in rats treated with nicotine
  JOURNAL   Toxicol Appl Pharmacol 96 (1), 132-139 (1988)
   PUBMED   2460970
REFERENCE   9  (bases 1 to 804)
  AUTHORS   Fletcher,T.S., Tsukamoto,H. and Largman,C.
  TITLE     Immunoenzymometric determination of trypsin/alpha 1-protease
            inhibitor complex in plasma of rats with experimental pancreatitis
  JOURNAL   Clin Chem 32 (9), 1738-1741 (1986)
   PUBMED   3527480
REFERENCE   10 (bases 1 to 804)
  AUTHORS   Majumdar,A.P., Vesenka,G.D., Dubick,M.A., Yu,G.S., DeMorrow,J.M.
            and Geokas,M.C.
  TITLE     Morphological and biochemical changes of the pancreas in rats
            treated with acetaldehyde
  JOURNAL   Am J Physiol 250 (5 Pt 1), G598-G606 (1986)
   PUBMED   2422952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from V01273.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: V01273.1, FQ211333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..804
                     /gene="Prss1"
                     /gene_synonym="PTRYI; RATPTRYI; Try1"
                     /note="serine protease 1"
                     /db_xref="GeneID:24691"
                     /db_xref="RGD:3417"
     exon            1..52
                     /gene="Prss1"
                     /gene_synonym="PTRYI; RATPTRYI; Try1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..753
                     /gene="Prss1"
                     /gene_synonym="PTRYI; RATPTRYI; Try1"
                     /EC_number="3.4.21.4"
                     /note="protease, serine, 2; anionic trypsin-1;
                     pretrypsinogen I; anionic trypsin I; pancreatic trypsin 1;
                     protease, serine, 1 (trypsin 1); protease, serine 1;
                     beta-trypsin; cationic trypsinogen"
                     /codon_start=1
                     /product="serine protease 1 precursor"
                     /protein_id="NP_036767.1"
                     /db_xref="GeneID:24691"
                     /db_xref="RGD:3417"
                     /translation="MSALLILALVGAAVAFPLEDDDKIVGGYTCPEHSVPYQVSLNSG
                     YHFCGGSLINDQWVVSAAHCYKSRIQVRLGEHNINVLEGDEQFINAAKIIKHPNYSSW
                     TLNNDIMLIKLSSPVKLNARVAPVALPSACAPAGTQCLISGWGNTLSNGVNNPDLLQC
                     VDAPVLSQADCEAAYPGEITSSMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGY
                     GCALPDNPGVYTKVCNFVGWIQDTIAAN"
     exon            53..212
                     /gene="Prss1"
                     /gene_synonym="PTRYI; RATPTRYI; Try1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..466
                     /gene="Prss1"
                     /gene_synonym="PTRYI; RATPTRYI; Try1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..603
                     /gene="Prss1"
                     /gene_synonym="PTRYI; RATPTRYI; Try1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..804
                     /gene="Prss1"
                     /gene_synonym="PTRYI; RATPTRYI; Try1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      804
                     /gene="Prss1"
                     /gene_synonym="PTRYI; RATPTRYI; Try1"
                     /note="polyA addition site"
ORIGIN      
        1 ccttctgcca ccatgagtgc acttctgatc ctagcccttg tgggagctgc tgttgctttc
       61 cctttggaag atgatgacaa gatcgttgga ggatacacct gcccggaaca ttctgtcccc
      121 taccaggtgt ccctgaactc tggctaccac ttctgtggag gttccctcat caatgaccag
      181 tgggtggtgt ctgcagctca ctgctacaaa tcccgcatcc aagtgagact gggagagcac
      241 aacatcaatg tccttgaggg cgatgagcaa tttatcaatg ctgccaagat catcaagcac
      301 cccaactata gttcgtggac cctgaacaat gacatcatgc tgatcaagct ctcttcccct
      361 gtgaaactca atgcccgagt ggcccctgta gctctgccca gcgcctgtgc acctgcaggc
      421 actcagtgcc tcatctctgg ctggggcaac accctcagca atggtgtgaa caacccagac
      481 ctgctccaat gcgtggatgc cccagtgctg tctcaggctg actgtgaagc cgcctaccct
      541 ggggaaatca ccagcagcat gatttgtgtt ggcttcctgg agggaggcaa agattcctgc
      601 cagggtgact ctggtggccc ggtggtctgc aatggacagc tccagggtat tgtctcctgg
      661 ggctatggtt gtgccctgcc agacaaccct ggtgtgtaca ccaaggtctg caactttgtg
      721 ggctggattc aggacaccat tgctgcaaac taaatatctt cagtctctct tcaatcagtg
      781 tgtcaataaa gttcatttgc cctc
//
