LOCUS       NM_153821               1377 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus paired related homeobox 1 (Prrx1), mRNA.
ACCESSION   NM_153821
VERSION     NM_153821.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1377)
  AUTHORS   Yin,L., Liu,M.X., Wang,F.Y., Wang,X., Tang,Y.H., Zhao,Q.Y.,
            Wang,T., Chen,Y.T. and Huang,C.X.
  TITLE     Transcription Factor prrx1 Promotes Brown Adipose-Derived Stem
            Cells Differentiation to Sinus Node-Like Cells
  JOURNAL   DNA Cell Biol 38 (11), 1313-1322 (2019)
   PUBMED   31545082
  REMARK    GeneRIF: Overexpression of prrx1 can successfully induce sinus
            node-like cells.
REFERENCE   2  (bases 1 to 1377)
  AUTHORS   Gong,J., Han,J., He,J., Liu,J., Han,P., Wang,Y., Li,M., Li,D.,
            Ding,X., Du,Z., Liao,J. and Tian,D.
  TITLE     Paired related homeobox protein 1 regulates PDGF-induced chemotaxis
            of hepatic stellate cells in liver fibrosis
  JOURNAL   Lab Invest 97 (9), 1020-1032 (2017)
   PUBMED   28737764
  REMARK    GeneRIF: Studied and identified Prrx1 as a novel valuable target in
            liver fibrosis. Prxx1 was found to have a major role in
            PDGF-induced migration and chemotaxis.
REFERENCE   3  (bases 1 to 1377)
  AUTHORS   Takahashi,T., Zimmer,J., Friedmacher,F. and Puri,P.
  TITLE     Expression of Prx1 and Tcf4 is decreased in the diaphragmatic
            muscle connective tissue of nitrofen-induced congenital
            diaphragmatic hernia
  JOURNAL   J Pediatr Surg 51 (12), 1931-1935 (2016)
   PUBMED   27665494
  REMARK    GeneRIF: expression of Prx1 and Tcf4 is decreased in the developing
            diaphragm in the nitrofen-induced congenital diaphragmatic hernia
            in Sprague- Dawley rats animal model.
REFERENCE   4  (bases 1 to 1377)
  AUTHORS   Liu,N., Xue,L., Guan,Y., Li,Q.Z., Cao,F.Y., Pang,S.L. and Guan,W.J.
  TITLE     Expression of Peroxiredoxins and Pulmonary Surfactant Protein A
            Induced by Silica in Rat Lung Tissue
  JOURNAL   Biomed Environ Sci 29 (8), 584-588 (2016)
   PUBMED   27660222
  REMARK    GeneRIF: Prdx1 and Prdx6 proteins is involved in pulmonary fibrosis
            induced by silica.
REFERENCE   5  (bases 1 to 1377)
  AUTHORS   Higuchi,M., Kato,T., Yoshida,S., Ueharu,H., Nishimura,N. and
            Kato,Y.
  TITLE     PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are
            involved in vasculogenesis during rat embryonic pituitary
            development
  JOURNAL   Cell Tissue Res 361 (2), 557-565 (2015)
   PUBMED   25795141
  REMARK    GeneRIF: PRRX1- and PRRX2-positive mesenchymal stem/progenitor
            cells are present at the periphery of the embryonic pituitary and
            participate in pituitary vasculogenesis by differentiation into
            vascular endothelial cells and pericytes.
REFERENCE   6  (bases 1 to 1377)
  AUTHORS   Lu,M.F., Cheng,H.T., Kern,M.J., Potter,S.S., Tran,B.,
            Diekwisch,T.G. and Martin,J.F.
  TITLE     prx-1 functions cooperatively with another paired-related homeobox
            gene, prx-2, to maintain cell fates within the craniofacial
            mesenchyme
  JOURNAL   Development 126 (3), 495-504 (1999)
   PUBMED   9876178
REFERENCE   7  (bases 1 to 1377)
  AUTHORS   Lu,M.F., Cheng,H.T., Lacy,A.R., Kern,M.J., Argao,E.A., Potter,S.S.,
            Olson,E.N. and Martin,J.F.
  TITLE     Paired-related homeobox genes cooperate in handplate and hindlimb
            zeugopod morphogenesis
  JOURNAL   Dev Biol 205 (1), 145-157 (1999)
   PUBMED   9882503
REFERENCE   8  (bases 1 to 1377)
  AUTHORS   ten Berge,D., Brouwer,A., Korving,J., Martin,J.F. and Meijlink,F.
  TITLE     Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region,
            inner ear and limbs
  JOURNAL   Development 125 (19), 3831-3842 (1998)
   PUBMED   9729491
REFERENCE   9  (bases 1 to 1377)
  AUTHORS   Hu,Y., Flanagan,J., Brennan,D.P., Zhou,H., Ng,K.W., Eisman,J.A. and
            Morrison,N.A.
  TITLE     rHox: a homeobox gene expressed in osteoblastic cells
  JOURNAL   J Cell Biochem 59 (4), 486-497 (1995)
   PUBMED   8749718
REFERENCE   10 (bases 1 to 1377)
  AUTHORS   Martin,J.F., Bradley,A. and Olson,E.N.
  TITLE     The paired-like homeo box gene MHox is required for early events of
            skeletogenesis in multiple lineages
  JOURNAL   Genes Dev 9 (10), 1237-1249 (1995)
   PUBMED   7758948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153821.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.52634.1,
                                           SRR26643285.36778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               JAXUCZ010000013.1  78203504-78204073   c
            571-746             JAXUCZ010000013.1  78151992-78152167   c
            747-928             JAXUCZ010000013.1  78146475-78146656   c
            929-1377            JAXUCZ010000013.1  78136783-78137231   c
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..1377
                     /gene="Prrx1"
                     /gene_synonym="Pmx1; Prx-1"
                     /note="paired related homeobox 1"
                     /db_xref="GeneID:266813"
                     /db_xref="RGD:628884"
     exon            1..570
                     /gene="Prrx1"
                     /gene_synonym="Pmx1; Prx-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1067
                     /gene="Prrx1"
                     /gene_synonym="Pmx1; Prx-1"
                     /note="rHox; paired-related homeobox protein 1; paired
                     mesoderm homeobox 1"
                     /codon_start=1
                     /product="paired mesoderm homeobox protein 1"
                     /protein_id="NP_722543.1"
                     /db_xref="GeneID:266813"
                     /db_xref="RGD:628884"
                     /translation="MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEE
                     AGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFN
                     SSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANK
                     NASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGI
                     NMANSIANLRLKAKEYSLQRNQVPTVN"
     exon            571..746
                     /gene="Prrx1"
                     /gene_synonym="Pmx1; Prx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..928
                     /gene="Prrx1"
                     /gene_synonym="Pmx1; Prx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1377
                     /gene="Prrx1"
                     /gene_synonym="Pmx1; Prx-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttc tttctgattt aagcttagcg tgtttgtttg tttggtttgg tttttaaact
       61 ttttttggtg tggattatct ctctggacca cgccggactt ggcttcagcg aagcaaccga
      121 agctgggaga aagttacttg tgctgaaagt tctgcacttc agaagggggt ttctctctct
      181 ctctctctct ctctctctct ctctctctct ctctctcctc cactcccccc tctttcttcc
      241 ccactcggct cctctccccc ctcacgccca cagcgtttgg tgttgattcg agcgggaaga
      301 ggggggtggg tgggattgga gggaagacca tgacctccag ctacgggcac gttctggagc
      361 ggcaaccggc tctgggcggc cgcttggata gccctggcaa cctcgacacc ctgcaggcga
      421 aaaagaactt ctccgtcagt cacctgctag acctggagga ggccggggac atggtggcgg
      481 cacaggcgga cgaaagcgtg ggcgaggcgg gccggagcct gctggagtca ccgggactga
      541 ccagtggcag cgacacccct cagcaggaca atgatcagct gaactctgag gagaagaaga
      601 agagaaagca acggagaaac aggacaacct tcaatagcag ccagctgcag gccttggagc
      661 gtgtcttcga gaggacccat tacccggatg cttttgtacg ggaagatctt gcacgtcggg
      721 tgaacctcac ggaggccaga gtgcaggtgt ggtttcagaa ccgaagagcc aagttccgca
      781 ggaatgagcg agccatgctg gccaataaaa acgcttctct cctcaagtcc tactcaggag
      841 acgtgactgc cgtggaacaa cccattgtac ctcgtcctgc tcccagaccc accgattatc
      901 tctcctgggg gacagcctct ccgtacagcg ccatggctac ttattctgcc acatgtgcca
      961 acaatagccc tgcgcagggt atcaacatgg ccaacagcat tgccaacctg agactgaagg
     1021 ccaaggaata tagtttacag aggaaccagg tgccaacagt caactgagga aaaaaataat
     1081 taaacaggcc taagaagaaa tcaaaaacca taagacacct atcctgttct gtcatttctt
     1141 catccgccgg aaaaaaaaag ataaaagcaa acaaacaaag ccagaactaa aatattggga
     1201 ccatggcgga gaaaagcagg agaggaacaa aatgaaaatt agttaacaaa tgtttcttct
     1261 tcctcttgga taccatcacc atttgttgtg tgtgtatttt ttttccttct acccatgctt
     1321 tgctaagtat acttcaggct tcttctatta ggctcaaccc acccattcct ataattg
//
