LOCUS       NM_001276470            2413 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus proline-rich transmembrane protein 2 (Prrt2),
            transcript variant 1, mRNA.
ACCESSION   NM_001276470 XM_001078254 XM_341931
VERSION     NM_001276470.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2413)
  AUTHORS   Mo,J., Wang,B., Zhu,X., Wu,X. and Liu,Y.
  TITLE     PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by
            influencing synaptic function in the primary motor cortex of rats
  JOURNAL   Neurobiol Dis 121, 274-285 (2019)
   PUBMED   30347267
  REMARK    GeneRIF: Study shows that proline-rich transmembrane protein 2
            (PRRT2) deficiency induces paroxysmal kinesigenic dyskinesia by
            influencing synaptic function in the primary motor cortex of rats.
            Results provide new insights into the function of PRRT2 in synaptic
            transmission and movement control.
REFERENCE   2  (bases 1 to 2413)
  AUTHORS   Tan,G.H., Liu,Y.Y., Wang,L., Li,K., Zhang,Z.Q., Li,H.F., Yang,Z.F.,
            Li,Y., Li,D., Wu,M.Y., Yu,C.L., Long,J.J., Chen,R.C., Li,L.X.,
            Yin,L.P., Liu,J.W., Cheng,X.W., Shen,Q., Shu,Y.S., Sakimura,K.,
            Liao,L.J., Wu,Z.Y. and Xiong,Z.Q.
  TITLE     PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by
            regulating synaptic transmission in cerebellum
  JOURNAL   Cell Res 28 (1), 90-110 (2018)
   PUBMED   29056747
REFERENCE   3  (bases 1 to 2413)
  AUTHORS   Liu,Y.T., Nian,F.S., Chou,W.J., Tai,C.Y., Kwan,S.Y., Chen,C.,
            Kuo,P.W., Lin,P.H., Chen,C.Y., Huang,C.W., Lee,Y.C., Soong,B.W. and
            Tsai,J.W.
  TITLE     PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental
            defects
  JOURNAL   Oncotarget 7 (26), 39184-39196 (2016)
   PUBMED   27172900
  REMARK    GeneRIF: PRRT2 mutations have roles in neuronal dysfunction and
            neurodevelopmental defects
REFERENCE   4  (bases 1 to 2413)
  AUTHORS   Valente,P., Castroflorio,E., Rossi,P., Fadda,M., Sterlini,B.,
            Cervigni,R.I., Prestigio,C., Giovedi,S., Onofri,F., Mura,E.,
            Guarnieri,F.C., Marte,A., Orlando,M., Zara,F., Fassio,A.,
            Valtorta,F., Baldelli,P., Corradi,A. and Benfenati,F.
  TITLE     PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter
            Release Machinery
  JOURNAL   Cell Rep 15 (1), 117-131 (2016)
   PUBMED   27052163
REFERENCE   5  (bases 1 to 2413)
  AUTHORS   Rossi,P., Sterlini,B., Castroflorio,E., Marte,A., Onofri,F.,
            Valtorta,F., Maragliano,L., Corradi,A. and Benfenati,F.
  TITLE     A Novel Topology of Proline-rich Transmembrane Protein 2 (PRRT2):
            HINTS FOR AN INTRACELLULAR FUNCTION AT THE SYNAPSE
  JOURNAL   J Biol Chem 291 (12), 6111-6123 (2016)
   PUBMED   26797119
  REMARK    Erratum:[J Biol Chem. 2018 Mar 23;293(12):4581. doi:
            10.1074/jbc.AAC118.002651.. PMID: 29572331]
REFERENCE   6  (bases 1 to 2413)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   7  (bases 1 to 2413)
  AUTHORS   Chen,W.J., Lin,Y., Xiong,Z.Q., Wei,W., Ni,W., Tan,G.H., Guo,S.L.,
            He,J., Chen,Y.F., Zhang,Q.J., Li,H.F., Lin,Y., Murong,S.X., Xu,J.,
            Wang,N. and Wu,Z.Y.
  TITLE     Exome sequencing identifies truncating mutations in PRRT2 that
            cause paroxysmal kinesigenic dyskinesia
  JOURNAL   Nat Genet 43 (12), 1252-1255 (2011)
   PUBMED   22101681
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Feb 17, 2013 this sequence version replaced
            XM_341931.5, XM_001078254.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213699.1, SRR26643298.5344.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000001.1  191059227-191059362 c
            137-1091            JAXUCZ010000001.1  191057603-191058557 c
            1092-1224           JAXUCZ010000001.1  191057111-191057243 c
            1225-2413           JAXUCZ010000001.1  191055772-191056960 c
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2413
                     /gene="Prrt2"
                     /gene_synonym="DSPB3; RGD1564195"
                     /note="proline-rich transmembrane protein 2"
                     /db_xref="GeneID:361651"
                     /db_xref="RGD:1564195"
     exon            1..136
                     /gene="Prrt2"
                     /gene_synonym="DSPB3; RGD1564195"
                     /inference="alignment:Splign:2.1.0"
     exon            137..1091
                     /gene="Prrt2"
                     /gene_synonym="DSPB3; RGD1564195"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1235
                     /gene="Prrt2"
                     /gene_synonym="DSPB3; RGD1564195"
                     /note="Dispanin subfamily B member 3"
                     /codon_start=1
                     /product="proline-rich transmembrane protein 2"
                     /protein_id="NP_001263399.1"
                     /db_xref="GeneID:361651"
                     /db_xref="RGD:1564195"
                     /translation="MAASSSEVSEMKGVEDSSNTHSEGPRHSEEGMGPVQVVAENLDQ
                     PEALQSGPDTTAAPVDSGPKAELAPETTETPVETPETVQATDLSVNPGEDSKTCPSPK
                     EACQEPASRPEVNREATAEQGAEQQSAAPPEPTSEQALQLNTQSDPQPTSQPPPKPPL
                     QAEPPTQENPTTEVLTESTGEKQENGAVVPLQAGDGEEGPAPQPHSPPSTKTPPANGA
                     PPRVLQKLVEEDRIGRAHGGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILA
                     ILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIA
                     SCVINLGVYK"
     exon            1092..1224
                     /gene="Prrt2"
                     /gene_synonym="DSPB3; RGD1564195"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..2413
                     /gene="Prrt2"
                     /gene_synonym="DSPB3; RGD1564195"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcccttca ttgctcacag acttgttccc tccccggtct gcggctgctg cagcagcggc
       61 ggcggcggcg gcggcgggac gcaggagcag tcccgaggct ggccacggat gagactggaa
      121 cgaactgaga ctgctggatt tgctactgtc attgctgttt tctcttcccc accggccctc
      181 tcccatctct cttctctaag atggcagcca gtagctctga ggtctctgag atgaaggggg
      241 tagaagacag ttccaacacc cactcagaag gtcccaggca ttctgaagaa ggaatgggtc
      301 ctgtccaggt tgtagcagag aacctagacc agccagaggc ccttcagtca ggcccagaca
      361 ccactgcagc ccctgtggac tcagggccta aggctgagct ggcaccagaa accacagaga
      421 ccccagttga aaccccagaa acagtccagg ccacagacct cagtgtaaac ccaggagaag
      481 actccaaaac ctgccccagc cccaaagagg catgccaaga gccggcatcc agaccagagg
      541 tgaacagaga ggctacagca gagcaagggg ctgagcagca gtctgcagcc cctcctgagc
      601 caacctcaga gcaggctttg cagctaaata cccagtcaga ccctcagcca acttcccagc
      661 ctcctcctaa accacccctt caggcagagc cccccaccca agagaaccct accacagagg
      721 tcctgacaga aagtacaggg gaaaaacaag aaaatggagc agtggttccc cttcaggctg
      781 gtgatgggga agagggccca gccccccagc ctcactcacc accctcaact aaaacacccc
      841 cagccaatgg tgcacccccc cgtgtgctgc agaagctggt tgaggaagac agaataggaa
      901 gggctcatgg tgggcatcca ggatctcctc gaggtagcct aagccgtcat cccagctccc
      961 agctggcagg tcctggggtg gaagggggtg aaggcaccca gaaacctcgg gactatatca
     1021 tccttgccat cctgtcctgc ttctgcccca tgtggcctgt caacattgtg gccttcgctt
     1081 atgccgtcat gtcccggaac agcctgcaac agggggacgt ggatggggct caacgtctgg
     1141 gtcgagtagc caagctctta agcatcgtgg cgctggttgg gggggtcctc atcatcatcg
     1201 cctcctgcgt catcaactta ggcgtgtata agtgaggggc tctgccctgc attccaagac
     1261 ttttcttcct gttgggagct gtcttgggtc catcccaatc ctgggagaat cccagtccat
     1321 ggccctggcc cccaccccta gggactgagg gagcctgagc gggccttgtt tacagcttct
     1381 tccctactcc tgcatcctgc caggctcctc tgccagccgt aggcttcctt tctccctgca
     1441 cttttgcctg cagatctccc ctcctgcctc ttgacccccc tagtcctgca ctctgaaaac
     1501 ccctctgcac ttctggacgc ctccctgaac atctaaattg tactctgcac ctccgcatcc
     1561 ctcccagcct ccttgcactt ctccctgccc ctggaatcct ctgaacctta attaaccctg
     1621 acctcccaac tttcattgtc ttggtatcta acccatccct ttcttccctt ccctaacatt
     1681 ctttcccctt gccacatccc ctgacccctt ctcatctttc ccttagcgtc ttcaccctcc
     1741 tgccaacact tagtctgcaa aacctgcagt acttaggtca ggctgaggga agaaggatgg
     1801 tgtggggaga ggtctgccta gctaggggct ctgactgttc tctactgggg accacccagg
     1861 cccagatcat acccccaccc taacccctaa ggtgcctatt gggtcgcaaa gctggcaagc
     1921 cagacctcac ctggggtact tgcacaagag tgggagtcct ggttctgaac attcagggga
     1981 ggaaggggta tagctgtggc tgaagagtca gcctaaattg acctgcccat ttgggctttt
     2041 taacctcaag agtttctcga aggtccattt atgtgctttg taaacagtag aattttaaaa
     2101 aaaatttaaa aaggaccaaa gttctcaact gcagggagca agggaagggc gcgagctctg
     2161 taatattctc taagaggacg agggaggttt gttgcacgcg acagcccact gaggaggcag
     2221 agagccagct gcgatgcatt tcggagttgg tcggtgtttt ttttgtttgt ttgtttgttt
     2281 tctttcttta aaaaaagttg gggggaaaac taaaattcct ttaaaaaaat aaaactgagt
     2341 ctcccttttt gtatgctgaa tgctgcatga gtcttaaaca ctaataaaca gagaatgcat
     2401 gagactggcc tca
//
