LOCUS       NM_001109116             970 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus proline rich 7 (synaptic) (Prr7), mRNA.
ACCESSION   NM_001109116 XM_001069340 XM_573986
VERSION     NM_001109116.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Inouye,M.O., Colameo,D., Ammann,I., Winterer,J. and Schratt,G.
  TITLE     miR-329- and miR-495-mediated Prr7 down-regulation is required for
            homeostatic synaptic depression in rat hippocampal neurons
  JOURNAL   Life Sci Alliance 5 (12), e202201520 (2022)
   PUBMED   36150742
  REMARK    GeneRIF: miR-329- and miR-495-mediated Prr7 down-regulation is
            required for homeostatic synaptic depression in rat hippocampal
            neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Hrdinka,M., Sudan,K., Just,S., Drobek,A., Stepanek,O., Schluter,D.,
            Reinhold,D., Jordan,B.A., Gintschel,P., Schraven,B. and Kreutz,M.R.
  TITLE     Normal Development and Function of T Cells in Proline Rich 7 (Prr7)
            Deficient Mice
  JOURNAL   PLoS One 11 (9), e0162863 (2016)
   PUBMED   27657535
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Kravchick,D.O., Karpova,A., Hrdinka,M., Lopez-Rojas,J., Iacobas,S.,
            Carbonell,A.U., Iacobas,D.A., Kreutz,M.R. and Jordan,B.A.
  TITLE     Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and
            regulates NMDA-mediated excitotoxicity
  JOURNAL   EMBO J 35 (17), 1923-1934 (2016)
   PUBMED   27458189
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Hrdinka,M., Draber,P., Stepanek,O., Ormsby,T., Otahal,P.,
            Angelisova,P., Brdicka,T., Paces,J., Horejsi,V. and Drbal,K.
  TITLE     PRR7 is a transmembrane adaptor protein expressed in activated T
            cells involved in regulation of T cell receptor signaling and
            apoptosis
  JOURNAL   J Biol Chem 286 (22), 19617-19629 (2011)
   PUBMED   21460222
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Murata,Y., Doi,T., Taniguchi,H. and Fujiyoshi,Y.
  TITLE     Proteomic analysis revealed a novel synaptic proline-rich membrane
            protein (PRR7) associated with PSD-95 and NMDA receptor
  JOURNAL   Biochem Biophys Res Commun 327 (1), 183-191 (2005)
   PUBMED   15629447
  REMARK    GeneRIF: PRR7 is involved in modulating neural activities via
            interactions with the NMDA receptor and postsynaptic density
            (PSD)-95, and PSD core formation
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474032.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_573986.2, XM_001069340.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840106,
                              SAMN12840107 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..970
                     /gene="Prr7"
                     /note="proline rich 7 (synaptic)"
                     /db_xref="GeneID:498704"
                     /db_xref="RGD:1561898"
     CDS             1..810
                     /gene="Prr7"
                     /note="synaptic proline-rich membrane protein"
                     /codon_start=1
                     /product="proline-rich protein 7"
                     /protein_id="NP_001102586.1"
                     /db_xref="GeneID:498704"
                     /db_xref="RGD:1561898"
                     /translation="MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEE
                     RLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHG
                     PAQPHAHPHPHHHALPHPPPSHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPP
                     YSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPA
                     APCPALCLQADRSRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV"
     exon            1..412
                     /gene="Prr7"
                     /inference="alignment:Splign:2.1.0"
     exon            413..970
                     /gene="Prr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgatgt cccagggcac ctacacgttc ctcacgtgct tcgccggctt ctggctcatc
       61 tggggtctca tcgtcctgct ctgctgcttc tgcagcttcc tgcgccgccg cctcaaacgg
      121 cgccaggagg agcgactgag ggagcagaac ctgcgcgccc tggagctgga gcccctcgag
      181 cttgagggca gcctggctgg aagtcctccg ggcctggcgc cgccaccgcc accgcaccgc
      241 agccgtctgg aggcgcctgt gcacgcgcac tcgcacgtgc acgtgcaccc tctgctgcac
      301 cacgggccgg cgcagccgca cgcgcacccg cacccacacc atcacgcact gccgcaccca
      361 ccgccgtcgc acctctccgt gccgccccgg ccctggagct atccgcgcca agcggaatcg
      421 gacatgtcta agccgccgtg ctacgaggag gcggtgctga tggccgagcc gccgccgccc
      481 tacagcgagg tgctcacgga cactcgcggc ctctaccgca agatcgtcac gccctttctg
      541 agccgccgcg acagcgcgga gaagcaggag cagccgcctc cgagttacaa gcctctcttc
      601 ctggaccggg gctatacctc ggcgctgcat cttcccagcg ccccgcggcc cgccgccccc
      661 tgccctgccc tctgtctgca ggcggaccgc agccgccgtg tcttccccag ctggaccgac
      721 tcagagctca gcagccgaga gcccctggag cacggagctt ggcgcctgcc cgtctccatc
      781 cccttgtttg ggaggactac agccgtatag aggggcgctc ggcgtcccga gccccacggg
      841 cgaactccta gcctgactgc gaggcttttt aaatgcttcc cttggactgc agggaggggt
      901 ggggggaggg agggatttct taccctgttt gttacatttt gaggataata aaggtgtgtg
      961 atctgctttg
//
