LOCUS       NM_001080150            2466 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus proline rich 5 like (Prr5l), mRNA.
ACCESSION   NM_001080150 XM_001071179 XM_001071217 XM_342471
VERSION     NM_001080150.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2466)
  AUTHORS   Gan,X., Wang,J., Wang,C., Sommer,E., Kozasa,T., Srinivasula,S.,
            Alessi,D., Offermanns,S., Simon,M.I. and Wu,D.
  TITLE     PRR5L degradation promotes mTORC2-mediated PKC-delta
            phosphorylation and cell migration downstream of Galpha12
  JOURNAL   Nat Cell Biol 14 (7), 686-696 (2012)
   PUBMED   22609986
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Laplante,M. and Sabatini,D.M.
  TITLE     mTOR signaling in growth control and disease
  JOURNAL   Cell 149 (2), 274-293 (2012)
   PUBMED   22500797
  REMARK    Review article
REFERENCE   3  (bases 1 to 2466)
  AUTHORS   Holmes,B., Artinian,N., Anderson,L., Martin,J., Masri,J.,
            Cloninger,C., Bernath,A., Bashir,T., Benavides-Serrato,A. and
            Gera,J.
  TITLE     Protor-2 interacts with tristetraprolin to regulate mRNA stability
            during stress
  JOURNAL   Cell Signal 24 (1), 309-315 (2012)
   PUBMED   21964062
REFERENCE   4  (bases 1 to 2466)
  AUTHORS   Pearce,L.R., Sommer,E.M., Sakamoto,K., Wullschleger,S. and
            Alessi,D.R.
  TITLE     Protor-1 is required for efficient mTORC2-mediated activation of
            SGK1 in the kidney
  JOURNAL   Biochem J 436 (1), 169-179 (2011)
   PUBMED   21413931
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129104.1.
            
            On or before Jan 13, 2007 this sequence version replaced
            XM_342471.3, XM_001071217.1, XM_001071179.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129104.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..2466
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /note="proline rich 5 like"
                     /db_xref="GeneID:362171"
                     /db_xref="RGD:1309969"
     exon            1..232
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
     exon            233..517
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1466
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /note="protein observed with Rictor-2"
                     /codon_start=1
                     /product="proline-rich protein 5-like"
                     /protein_id="NP_001073619.1"
                     /db_xref="GeneID:362171"
                     /db_xref="RGD:1309969"
                     /translation="MTRGLAPLLPIEFHKMGSFRRPRPRFMSSPLLSELPRFQAARQA
                     LQLSSNSAWNSVQTAVINVFKGGGLQSNELYALNESIRRLLKSELGSFITDYFQNQLL
                     AKGLSFVEEKIKQCEGDNRIEVLAEVWDHFFTETLPTLQAIFYPVQGQELTIRQISLL
                     GFRDLVLLKVKLGDLLLLSQSKLPSSVIQMLLILQSVHEPTGPSEGYLQLEELVKQVV
                     SPFLGLSGDRSCSRPTHSLARRHSRVRPKVTVLNYASLMTTVGRPLNEMVLTPLTEQE
                     GEAYLEKCGSVRRHTVANAHSDIQLLAMATMMHSGLGEESGSEDKHLLLPPTFPPPHR
                     QCSSEPSILDSPDEMELEDVASGSQEDSELNCASLS"
     exon            518..598
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
     exon            599..647
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
     exon            648..705
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
     exon            706..797
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
     exon            798..938
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1065
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..2318
                     /gene="Prr5l"
                     /gene_synonym="Protor-2; Protor2; RGD1309969"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgaagag aaacctgagc aggacacgac ccagcggagg gcagaggtgg gagaggacct
       61 cgggagggcg agcgaggcaa gaacaatcca aaatcgctgg tttctctcca gcgagaaaac
      121 tttccttggg acgacggaaa cttttttcct gcgcgcgcag agtctgggac agaggcgagc
      181 ggcgggtgta cgcggctccg ctcctgtgac tcacgcccgg gaccccaagg gggtgctggc
      241 tgacagtagg gttttaagac accccagaag cagcgttgag ggaagccttt ctttcctgtg
      301 ggtggccaga agcttctggt cctcaagaca cagctcaatc ctcacctgga cttatgaccc
      361 gcggccttgc tcccctcctg cccattgagt tccacaagat gggctccttc cgccggccta
      421 gaccacgatt tatgagctcc cctctgctca gcgagctgcc ccgctttcag gctgcccggc
      481 aggctctgca actaagttcc aactcagcct ggaacagtgt gcagacggct gtgatcaacg
      541 ttttcaaagg gggcggcttg cagagcaatg agctgtatgc actgaacgaa agcatcaggc
      601 ggctgctgaa gagtgaactt ggatcgttca ttactgacta cttccagaac cagcttcttg
      661 caaaaggact gtcctttgtg gaggagaaga tcaagcagtg tgaaggtgac aatcgcattg
      721 aggttctggc tgaagtctgg gaccacttct tcaccgagac actccctacc ctgcaggcaa
      781 tattttatcc ggttcaggga caggagctga ccatccgcca gatctccctg ctgggcttcc
      841 gggacctggt cttgctgaag gtgaagctgg gtgacttgct gctgttgtca cagtccaagt
      901 tgccttcttc tgttatacag atgcttctca ttctgcagag tgttcacgag cccacaggcc
      961 caagtgaggg ctatttgcag ctggaggagc tggtgaagca agtggtgtct cccttcctcg
     1021 gcctcagcgg ggaccgcagc tgctcacgcc ccacacactc actggccagg aggcattcca
     1081 gggtccggcc caaggtgacc gtcctgaact atgcctctct gatgaccacg gttggccggc
     1141 cactgaatga gatggtcttg acccctctaa cagaacagga aggagaggca tacctggaga
     1201 agtgtggcag cgtccggcgg cacacagtgg ccaatgccca ctcggacatc cagctgctgg
     1261 ctatggccac catgatgcac tcagggttgg gggaggagtc tggaagcgag gacaaacacc
     1321 tgctcctgcc acccaccttc ccaccaccac accgccaatg ctccagtgag cccagcatcc
     1381 ttgatagtcc tgatgaaatg gaactggaag atgtagcaag tggcagccaa gaggactcag
     1441 agctgaattg tgcttccctc agctgagcca ccacctccag ggacccattc ctactttgag
     1501 gctaggatga ggacaccctt cctcctccac ggatcaccca ggggctcttg cattgggcaa
     1561 tattgcctta cttcctttag ggcacaagtc aagtctccac gcccttggga aacacctgtt
     1621 gacctcccaa ctctggtgtc tgtgaccagc tcctcatgcc accgttgttc tgacttccag
     1681 ccttgcctca ttcacctgga tcctcatccc tgggccttcc gcatcctatt ggactgactg
     1741 gtactcctgg gatataatgc tctggcatta tttttatagc agaaggttgg gctactacac
     1801 acgagcttct gaagtgtgcc aatctctgta gtttctgtta tgatcttatg aggcagaagc
     1861 caacgggtgg aaaaaacagt aaagattctg tgtagcatgg aaatcagctg cagcccgtat
     1921 cgtacatggt actgggaatg tggcctcatc actttaattg cagagttact gggaaaccat
     1981 tttcccactt gtgggcgaag attcattctt aggaatgtcc agatatcatg ttctgtctac
     2041 atcatggact ttggcctagg agaacgtatt agactggcac ggccctgtct tgcattaagc
     2101 ctctcagcct gtctgtctca ggcttcctct cagactctgg gaatgaacct tctcagtcac
     2161 tggtgcctta ctctttctcc agtttcagga actgaccact tttctgttgt gtatacgaga
     2221 ggctgctgac agaagctgat gtagactgta cctggatttc acttgaattt gtaaaatgtg
     2281 tattgctcaa aaaaaatgtt tgcaaatatt tgcacataaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaa
//
