LOCUS       NM_203332                804 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus proline rich 4 (Prr4), mRNA.
ACCESSION   NM_203332 XM_346714
VERSION     NM_203332.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 804)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 804)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 804)
  AUTHORS   Cooper,L.F., Elia,D.M. and Tabak,L.A.
  TITLE     Secretagogue-coupled changes in the expression of
            glutamine/glutamic acid-rich proteins (GRPs). Isoproterenol induces
            changes in GRP transcript expression and changes in isoforms
            secreted
  JOURNAL   J Biol Chem 266 (6), 3532-3539 (1991)
   PUBMED   1995617
REFERENCE   4  (bases 1 to 804)
  AUTHORS   Mirels,L., Bedi,G.S., Dickinson,D.P., Gross,K.W. and Tabak,L.A.
  TITLE     Molecular characterization of glutamic acid/glutamine-rich
            secretory proteins from rat submandibular glands
  JOURNAL   J Biol Chem 262 (15), 7289-7297 (1987)
   PUBMED   2438276
REFERENCE   5  (bases 1 to 804)
  AUTHORS   Heinrich,G. and Habener,J.F.
  TITLE     Genes encoding proteins with homologous contiguous repeat sequences
            are highly expressed in the serous cells of the rat submandibular
            gland
  JOURNAL   J Biol Chem 262 (11), 5262-5270 (1987)
   PUBMED   3558393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 18, 2022 this sequence version replaced NM_203332.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676789
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000004.1  168336501-168336596
            97-132              JAXUCZ010000004.1  168337452-168337487
            133-710             JAXUCZ010000004.1  168338406-168338983
            711-804             JAXUCZ010000004.1  168340207-168340300
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..804
                     /gene="Prr4"
                     /gene_synonym="CRP; GRP-CA; GRP-CB; Grpca; Grpcb"
                     /note="proline rich 4"
                     /db_xref="GeneID:360395"
                     /db_xref="RGD:735181"
     exon            1..96
                     /gene="Prr4"
                     /gene_synonym="CRP; GRP-CA; GRP-CB; Grpca; Grpcb"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..710
                     /gene="Prr4"
                     /gene_synonym="CRP; GRP-CA; GRP-CB; Grpca; Grpcb"
                     /note="submandibular gland secretory Glx-rich protein CB;
                     glutamine/glutamic acid-rich protein B; contiguous repeat
                     polypeptide; glutamine/glutamic acid-rich protein A;
                     hypothetical gene supported by M31032, NM_181440;
                     rCG29588-like; Submandibular gland secretory Glx-rich
                     protein CA"
                     /codon_start=1
                     /product="submandibular gland secretory Glx-rich protein
                     CB precursor"
                     /protein_id="NP_976077.2"
                     /db_xref="GeneID:360395"
                     /db_xref="RGD:735181"
                     /translation="MLVVLLTAALLALSSAQGTDEEVNNAETSDVPADSEQQPVDSGS
                     DPPSADADAENVQEGESAPPANEEPPATSGSEEEQQQQEPTQAENQEPPATSGSEEEQ
                     QQQEPTQAENQEPPATSGSEEEQQQQESTQAENQEPSDSAGEGQETQPEEGNVESPPS
                     SPENSQEQPQQTNPEEKPPAPKTQEEPQHYRGRPPKKIFPFFIYRGRPVVVFRPRRPR
                     NPFARRF"
     exon            97..132
                     /gene="Prr4"
                     /gene_synonym="CRP; GRP-CA; GRP-CB; Grpca; Grpcb"
                     /inference="alignment:Splign:2.1.0"
     exon            133..710
                     /gene="Prr4"
                     /gene_synonym="CRP; GRP-CA; GRP-CB; Grpca; Grpcb"
                     /inference="alignment:Splign:2.1.0"
     exon            711..804
                     /gene="Prr4"
                     /gene_synonym="CRP; GRP-CA; GRP-CB; Grpca; Grpcb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctgggag aaagtccata gactcctcca agatgcttgt ggtcctgctc acagcagcct
       61 tgctggctct gagctcagct cagggcacag atgaagaggt caacaatgct gagaccagtg
      121 atgtaccagc agattctgaa caacaacccg tggactcggg ttcagatcca ccttctgctg
      181 atgcagatgc agagaatgtt caagagggtg aatcagcccc accagcaaat gaagagcctc
      241 ctgccacttc tgggagtgaa gaggaacagc agcagcagga acccacacag gcagagaatc
      301 aagagcctcc tgccacctct gggagtgaag aggaacagca gcagcaggaa cccacacagg
      361 cagagaatca agagcctcct gccacctctg ggagtgaaga ggaacagcag cagcaggaat
      421 ccacacaggc agagaatcaa gagccttctg actctgctgg ggaaggacag gaaactcaac
      481 ctgaggaagg aaatgtagag tcacctccct cttctcctga aaactcacaa gaacaaccac
      541 agcaaacaaa tccagaggag aaaccgcctg ctcctaagac tcaggaagag ccacagcact
      601 atagaggtcg tcctccaaag aagatttttc cttttttcat ttacagagga agaccagtag
      661 tagtattcag gcctcgaaga cctaggaatc cattcgccag aagattttag agagtacctg
      721 agaagattat gaccttcaga tgtgtaggtc aacaaatcac tgttgattgt ctataatatt
      781 ccaataaaaa ttttcagcat gcaa
//
