LOCUS       NM_012634               2683 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus phosphoribosyl pyrophosphate synthetase 2
            (Prps2), mRNA.
ACCESSION   NM_012634
VERSION     NM_012634.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2683)
  AUTHORS   Camici,M., Micheli,V., Ipata,P.L. and Tozzi,M.G.
  TITLE     Pediatric neurological syndromes and inborn errors of purine
            metabolism
  JOURNAL   Neurochem Int 56 (3), 367-378 (2010)
   PUBMED   20005278
  REMARK    Review article
REFERENCE   2  (bases 1 to 2683)
  AUTHORS   Sonoda,T., Ishizuka,T., Ishijima,S., Kita,K., Ahmad,I. and
            Tatibana,M.
  TITLE     Rat liver phosphoribosylpyrophosphate synthetase is activated by
            free Mg2+ in a manner that overcomes its inhibition by nucleotides
  JOURNAL   Biochim Biophys Acta 1387 (1-2), 32-40 (1998)
   PUBMED   9748490
REFERENCE   3  (bases 1 to 2683)
  AUTHORS   Ishijima,S., Asai,T., Kita,K., Sonoda,T. and Tatibana,M.
  TITLE     Partial reconstitution of mammalian phosphoribosylpyrophosphate
            synthetase in Escherichia coli cells. Coexpression of catalytic
            subunits with the 39-kDa associated protein leads to formation of
            soluble multimeric complexes of various compositions
  JOURNAL   Biochim Biophys Acta 1342 (1), 28-36 (1997)
   PUBMED   9366267
REFERENCE   4  (bases 1 to 2683)
  AUTHORS   Sonoda,T., Kita,K., Ishijima,S., Ishizuka,T., Ahmad,I. and
            Tatibana,M.
  TITLE     Kinetic and regulatory properties of rat liver
            phosphoribosylpyrophosphate synthetase complex are partly distinct
            from those of isolated recombinant component catalytic subunits
  JOURNAL   J Biochem 122 (3), 635-640 (1997)
   PUBMED   9348095
REFERENCE   5  (bases 1 to 2683)
  AUTHORS   Ishijima,S., Kita,K., Ahmad,I., Ishizuka,T., Taira,M. and
            Tatibana,M.
  TITLE     Expression of rat phosphoribosylpyrophosphate synthetase subunits I
            and II in Escherichia coli. Isolation and characterization of the
            recombinant isoforms
  JOURNAL   J Biol Chem 266 (24), 15693-15697 (1991)
   PUBMED   1651917
REFERENCE   6  (bases 1 to 2683)
  AUTHORS   Ishijima,S., Taira,M. and Tatibana,M.
  TITLE     Complete cDNA sequence of rat phosphoribosylpyrophosphate
            synthetase subunit II (PRS II)
  JOURNAL   Nucleic Acids Res 17 (21), 8859 (1989)
   PUBMED   2555778
REFERENCE   7  (bases 1 to 2683)
  AUTHORS   Kita,K., Otsuki,T., Ishizuka,T. and Tatibana,M.
  TITLE     Rat liver phosphoribosyl pyrophosphate synthetase: existence of the
            purified enzyme as heterogeneous aggregates and identification of
            the catalytic subunit
  JOURNAL   J Biochem 105 (5), 736-741 (1989)
   PUBMED   2546925
REFERENCE   8  (bases 1 to 2683)
  AUTHORS   Taira,M., Ishijima,S., Kita,K., Yamada,K., Iizasa,T. and
            Tatibana,M.
  TITLE     Nucleotide and deduced amino acid sequences of two distinct cDNAs
            for rat phosphoribosylpyrophosphate synthetase
  JOURNAL   J Biol Chem 262 (31), 14867-14870 (1987)
   PUBMED   2822704
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012634.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16555.1, M17259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               JAXUCZ010000021.1  30592845-30593300
            457-640             JAXUCZ010000021.1  30601632-30601815
            641-739             JAXUCZ010000021.1  30610484-30610582
            740-864             JAXUCZ010000021.1  30611958-30612082
            865-1038            JAXUCZ010000021.1  30622613-30622786
            1039-1198           JAXUCZ010000021.1  30625101-30625260
            1199-2683           JAXUCZ010000021.1  30627530-30629014
FEATURES             Location/Qualifiers
     source          1..2683
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..2683
                     /gene="Prps2"
                     /note="phosphoribosyl pyrophosphate synthetase 2"
                     /db_xref="GeneID:24689"
                     /db_xref="RGD:3415"
     exon            1..456
                     /gene="Prps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1291
                     /gene="Prps2"
                     /EC_number="2.7.6.1"
                     /note="PRS-II; phosphoribosyl pyrophosphate synthetase II;
                     phosphoribosyl pyrophosphate synthase II;
                     Phophoribosylpyrophosphate synthetase, subunit II;
                     ribose-phosphate pyrophosphokinase 2-like"
                     /codon_start=1
                     /product="ribose-phosphate pyrophosphokinase 2"
                     /protein_id="NP_036766.1"
                     /db_xref="GeneID:24689"
                     /db_xref="RGD:3415"
                     /translation="MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEI
                     GESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDK
                     SRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIT
                     EWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAIL
                     VDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIP
                     QEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL"
     exon            457..640
                     /gene="Prps2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..739
                     /gene="Prps2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..864
                     /gene="Prps2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1038
                     /gene="Prps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1198
                     /gene="Prps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2683
                     /gene="Prps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtacct gcgttcttcg ggaccaccca gagcttcaaa cactgctgcc cagcctgcgt
       61 gggcagaagc agaggcccag caccctccag cgactcttgg gctgctcctc ctccctctgg
      121 ctcctcccct agcccgcccc ttccctagat cctgctgccg cgttttcccg cttcaccagc
      181 agcggcggcc accgcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc
      241 agcggcggcg gcaactgcag cagccaccgt agcagcagtc tgcgtcgcgg tcgctttctc
      301 cttctctggc gcgcttcagt ccccgtgagt caccatgccc aacatcgtgc tcttcagcgg
      361 cagctctcac caggacctgt cgcagcgcgt ggccgatcgc ctgggcctgg agctgggcaa
      421 ggtggtcacc aagaagttta gcaaccagga gaccagtgtc gagattggtg aaagtgtgcg
      481 aggggaagat gtctatatca tccagagcgg ctgtggggaa attaatgaca acttgatgga
      541 gctactcatc atgatcaacg cgtgcaagat tgcatcctca tccagggtaa cagctgtgat
      601 accctgcttc ccctacgccc ggcaagataa aaaggacaag agtcgtgctc caatttctgc
      661 taagcttgtg gccaatatgt tgtcagttgc tggggctgat cacatcatta ccatggacct
      721 gcatgcctct cagatccagg gcttctttga tattcctgtg gataatttat atgcagaacc
      781 tgcagttctt cagtggattc gggagaacat cactgaatgg agaaactgta ttattgtttc
      841 tccagatgct ggaggagcca aaagggttac gtcaattgca gacagactga atgtggaatt
      901 tgctttgatt cacaaagaga gaaagaaagc aaatgaagtg gaccggatgg ttcttgtggg
      961 cgatgtgaag gaccgtgtgg ctatcctggt ggacgacatg gctgacacat gtggtaccat
     1021 ctgtcatgct gcagataagt tactctcagc tggtgccacc aaagtttatg ctattcttac
     1081 ccatggaatc ttctctgggc cagctatttc cagaataaat aatgctgcct ttgaagcagt
     1141 tgttgtcacc aataccattc cacaagagga caaaatgaaa cactgttcca aaattcaggt
     1201 gatcgacatt tcaatgattc tggctgaagc cattcgaaga acccacaatg gggaatccgt
     1261 gtcctatctg ttcagccatg tcccgctgta gtctggattg gaatattgaa gggggagcaa
     1321 gcctcctcca acttctcact gtctttgtct gcctgctgtt ttagcattag gactcagcaa
     1381 ttctaggatg atcactggca aaagcgtctg atctatgtac actctgaggg tcctctgtct
     1441 cctcaagggc aagactacta cttagcagtt ctgggggagg gcagaggaag gtgctggtta
     1501 tttggtcttt aaatgaagtg atgtcaatga gaaaatagtc ttttccctca ttctttttta
     1561 gtactttgag gcaacaactt ttaagcctaa aatcccattg tggaaatttg tcatacatat
     1621 attttgaggt tgccaaaggt gacttcaaat gaaagccttc tgtgtaaata tataataagg
     1681 cctgtggcta tttggggaaa atcctaaata gcctttattt cagagagaac cttggaaaat
     1741 ttatactatc atgaattttg aaattttttt aataataacg gtttattttt ttgtccttta
     1801 tcaggactga attttattga gtctaagcta gtcattgaca tactgacttt ccttagtaga
     1861 tattagacat attgaagaca atataaggct gtaccatttt taatcaccac tttgaagata
     1921 tgtcataact gtcaacttaa ctaaaactcc cagattatga tcagtgatca ctgtgatttg
     1981 gataccattt caggatgtag caatgatttt gtggccacct agatgtacaa ctttgtgtat
     2041 cccaggggaa ttactcttta ggatgacgct cacgtccatg catttttccc taataatttc
     2101 ttcttgtaga tgtcttccaa aagagagact ccttgaaatc cccttacatt ttttggctga
     2161 ttagtatttt ttttcacata cataaaatag tgaagtgtcg aatgccatca aatgtattta
     2221 ttcaaaaatt gcataattat gcttgagtta aatgttcttc ggccctatgt catcggaagt
     2281 cctaaatttc taatgactag ttatctctaa agctgctaaa atgtagatag gagatggcta
     2341 caaaacagtg gctacaaaag tgaatgtctg atccattaaa ataaacttca aagaaatggc
     2401 tcggaaagct tagggaagaa gaatctcatt atggatggta ttctttataa aacaatcttt
     2461 tagtgaagtg tggaggtctg tgcggaccac atgtttaagg ccagcctggg ctatacagtg
     2521 agttccaact tagcttgggc tgcagaatta gactgtgtgt cataaaacca aatgaaacaa
     2581 caaaggcagt tctctatgtc atcattaaaa gtggacaacc tatcattttc cttctcacca
     2641 agaagaggat ttgcctgtgt acctaaagct taggaatgct aac
//
