LOCUS       NM_017243               1999 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phosphoribosyl pyrophosphate synthetase 1
            (Prps1), mRNA.
ACCESSION   NM_017243
VERSION     NM_017243.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1999)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1999)
  AUTHORS   Gandia,M., Fernandez-Toral,J., Solanellas,J., Dominguez-Ruiz,M.,
            Gomez-Rosas,E., Del Castillo,F.J., Villamar,M., Moreno-Pelayo,M.A.
            and Del Castillo,I.
  TITLE     Mutations in PRPS1 causing syndromic or nonsyndromic hearing
            impairment: intrafamilial phenotypic variation complicates genetic
            counseling
  JOURNAL   Pediatr Res 78 (1), 97-102 (2015)
   PUBMED   25785835
REFERENCE   3  (bases 1 to 1999)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   4  (bases 1 to 1999)
  AUTHORS   Wei,X., Das,J., Fragoza,R., Liang,J., Bastos de Oliveira,F.M.,
            Lee,H.R., Wang,X., Mort,M., Stenson,P.D., Cooper,D.N., Lipkin,S.M.,
            Smolka,M.B. and Yu,H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1999)
  AUTHORS   Almoguera,B., He,S., Corton,M., Fernandez-San Jose,P.,
            Blanco-Kelly,F., Lopez-Molina,M.I., Garcia-Sandoval,B., Del Val,J.,
            Guo,Y., Tian,L., Liu,X., Guan,L., Torres,R.J., Puig,J.G.,
            Hakonarson,H., Xu,X., Keating,B. and Ayuso,C.
  TITLE     Expanding the phenotype of PRPS1 syndromes in females: neuropathy,
            hearing loss and retinopathy
  JOURNAL   Orphanet J Rare Dis 9, 190 (2014)
   PUBMED   25491489
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1999)
  AUTHORS   Ishijima,S., Kita,K., Ahmad,I., Ishizuka,T., Taira,M. and
            Tatibana,M.
  TITLE     Expression of rat phosphoribosylpyrophosphate synthetase subunits I
            and II in Escherichia coli. Isolation and characterization of the
            recombinant isoforms
  JOURNAL   J Biol Chem 266 (24), 15693-15697 (1991)
   PUBMED   1651917
REFERENCE   7  (bases 1 to 1999)
  AUTHORS   Shimada,H., Taira,M., Yamada,K., Iizasa,T. and Tatibana,M.
  TITLE     Structure of the rat PRPS1 gene encoding
            phosphoribosylpyrophosphate synthetase subunit I
  JOURNAL   J Biol Chem 265 (7), 3956-3960 (1990)
   PUBMED   2154494
REFERENCE   8  (bases 1 to 1999)
  AUTHORS   Ishijima,S., Taira,M. and Tatibana,M.
  TITLE     Complete cDNA sequence of rat phosphoribosylpyrophosphate
            synthetase subunit I (PRS I)
  JOURNAL   Nucleic Acids Res 17 (21), 8860 (1989)
   PUBMED   2555779
REFERENCE   9  (bases 1 to 1999)
  AUTHORS   Kita,K., Otsuki,T., Ishizuka,T. and Tatibana,M.
  TITLE     Rat liver phosphoribosyl pyrophosphate synthetase: existence of the
            purified enzyme as heterogeneous aggregates and identification of
            the catalytic subunit
  JOURNAL   J Biochem 105 (5), 736-741 (1989)
   PUBMED   2546925
REFERENCE   10 (bases 1 to 1999)
  AUTHORS   Taira,M., Ishijima,S., Kita,K., Yamada,K., Iizasa,T. and
            Tatibana,M.
  TITLE     Nucleotide and deduced amino acid sequences of two distinct cDNAs
            for rat phosphoribosylpyrophosphate synthetase
  JOURNAL   J Biol Chem 262 (31), 14867-14870 (1987)
   PUBMED   2822704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB702494.1, X16554.1, CO405720.1 and CK841243.1.
            
            On Apr 25, 2008 this sequence version replaced NM_017243.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16554.1, M17258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                CB702494.1         1-73
            74-878              X16554.1           71-875
            879-1520            CO405720.1         29-670
            1521-1999           CK841243.1         1-479               c
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..1999
                     /gene="Prps1"
                     /note="phosphoribosyl pyrophosphate synthetase 1"
                     /db_xref="GeneID:29562"
                     /db_xref="RGD:61955"
     exon            1..236
                     /gene="Prps1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1071
                     /gene="Prps1"
                     /EC_number="2.7.6.1"
                     /note="PRS-I; phosphoribosyl pyrophosphate synthetase I;
                     phosphoribosyl pyrophosphate synthase I"
                     /codon_start=1
                     /product="ribose-phosphate pyrophosphokinase 1"
                     /protein_id="NP_058939.1"
                     /db_xref="GeneID:29562"
                     /db_xref="RGD:61955"
                     /translation="MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEI
                     GESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDK
                     SRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENIS
                     EWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAIL
                     VDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIP
                     QEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL"
     exon            237..420
                     /gene="Prps1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..519
                     /gene="Prps1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..644
                     /gene="Prps1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..818
                     /gene="Prps1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..978
                     /gene="Prps1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1985
                     /gene="Prps1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagcaacgcg gttctgttgg tgttcaggtt ccctactgac ttcccttcca gtggcagcgg
       61 cggaggcggc agcggcagcg gcaagcactg agcacgtttg ggtagttgtc caagatgccg
      121 aatatcaaaa tcttcagcgg gagctcccac caggacttat cccagaaaat tgctgaccgc
      181 ctgggcctgg agctaggcaa ggtggtgact aagaaattca gcaaccagga gacctgtgtg
      241 gaaattgggg agagtgttcg tggagaggat gtctacattg ttcagagtgg ctgcggtgag
      301 ataaatgaca atctaatgga gcttttgatc atgatcaatg cttgcaagat cgcttctgcc
      361 agccgggtta ctgcggtcat cccatgcttc ccttatgccc ggcaggataa gaaggataag
      421 agccgggctc caatctcagc taagcttgtt gcaaatatgc tatctgtagc aggtgcggat
      481 catattatca ccatggatct acatgcatct cagattcagg gcttctttga tatcccagtg
      541 gacaatttat acgcagagcc agctgtcctg aagtggattc gggagaacat atctgagtgg
      601 agaaactgta ctattgtctc acctgacgct ggcggagcca agagagtgac ctccattgca
      661 gaccgattga atgtggattt tgctttgatt cacaaagaac ggaagaaggc caatgaagtg
      721 gaccgcatgg tactagtagg agatgtgaag gatcgtgtgg ctatacttgt ggatgacatg
      781 gctgacactt gtggtacaat ttgtcatgct gctgacaaac ttctctcagc tggagctacc
      841 agagtttatg ccattttgac gcatgggatc ttttctggcc cagccatttc tcgcatcaac
      901 aatgcatgct ttgaagcagt agtagttacc aataccatac ctcaggagga caagatgaaa
      961 cactgctcca aaatccaggt gatcgacatc tctatgatcc ttgcagaagc catcaggaga
     1021 acccacaatg gagaatctgt ctcctacctg ttcagccatg ttcctctata atatcataaa
     1081 ttctgaagcg ttttcaaaat gaaaccaccc ccaccccttg tttttcttgt atttggtgag
     1141 ttgggcagaa gagccggctt gcttcagtgt agctttttac agcccacatt agctacatta
     1201 ggatttatcc taattggaga aagacagact gctattaact gctaagacac cctacgtgca
     1261 ttgttgcagc ctggctttct tgtttatttt gtgatccttg cagctttaaa ttgagttcca
     1321 ctgttgaaag ctgcatagac tgttaaaaga gagagtattc cccaaggtcc ttaggatgga
     1381 attgtggagc tcatactccg ttgcatgtga aggctttgga gtttccttca ttcagaataa
     1441 ctagcgacaa agccagccct cgtgtgatac attttcagag gtctatgcta cactgcagca
     1501 agttccctgt gcatccttaa acagagttca ctgctgagca ccctgtacgg caggggcggg
     1561 tagctcaatg cagtaattaa tttttgggag gaagaagcct gatctattat catctgttta
     1621 attctctgta gcttggatcc tctatgccta ttcctttcct gttggcttca ccttcagcta
     1681 tctcgaccct ttcctggaca aatatcttga actcagtgat cattgtttgt gacaaaatct
     1741 tctgtaagac agacttgctt cttgctatgt aactgctaac gttgacatta ggtaacttgc
     1801 tatagcacaa tcttccttag cccgctctct ctgagttagt gggttttagg tggtgtgtgt
     1861 gtcgtagtgc cttttgatta atttaagtat ttaattttta tcttccttcg atctgtttgg
     1921 cttaacaatt tgatcttatt gtctcatgta gaagaaactt aataaaatgt ctgtcatgtg
     1981 tacaaaaaaa aaaaaaaaa
//
