LOCUS       NM_013021               1559 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus peripherin 2 (Prph2), mRNA.
ACCESSION   NM_013021
VERSION     NM_013021.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Wang,X., Wang,H., Sun,V., Tuan,H.F., Keser,V., Wang,K., Ren,H.,
            Lopez,I., Zaneveld,J.E., Siddiqui,S., Bowles,S., Khan,A., Salvo,J.,
            Jacobson,S.G., Iannaccone,A., Wang,F., Birch,D., Heckenlively,J.R.,
            Fishman,G.A., Traboulsi,E.I., Li,Y., Wheaton,D., Koenekoop,R.K. and
            Chen,R.
  TITLE     Comprehensive molecular diagnosis of 179 Leber congenital amaurosis
            and juvenile retinitis pigmentosa patients by targeted next
            generation sequencing
  JOURNAL   J Med Genet 50 (10), 674-688 (2013)
   PUBMED   23847139
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Chakraborty,D., Conley,S.M. and Naash,M.I.
  TITLE     Overexpression of retinal degeneration slow (RDS) protein adversely
            affects rods in the rd7 model of enhanced S-cone syndrome
  JOURNAL   PLoS One 8 (5), e63321 (2013)
   PUBMED   23650562
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Fakin,A., Zupan,A., Glavac,D. and Hawlina,M.
  TITLE     Combination of retinitis pigmentosa and hearing loss caused by a
            novel mutation in PRPH2 and a known mutation in GJB2: importance
            for differential diagnosis of Usher syndrome
  JOURNAL   Vision Res 75, 71-76 (2012)
   PUBMED   22842402
REFERENCE   5  (bases 1 to 1559)
  AUTHORS   Hagstrom,S.A., Watson,R.F., Pauer,G.J. and Grossman,G.H.
  TITLE     Tulp1 is involved in specific photoreceptor protein transport
            pathways
  JOURNAL   Adv Exp Med Biol 723, 783-789 (2012)
   PUBMED   22183407
REFERENCE   6  (bases 1 to 1559)
  AUTHORS   Gorin,M.B., Jackson,K.E., Ferrell,R.E., Sheffield,V.C.,
            Jacobson,S.G., Gass,J.D., Mitchell,E. and Stone,E.M.
  TITLE     A peripherin/retinal degeneration slow mutation (Pro-210-Arg)
            associated with macular and peripheral retinal degeneration
  JOURNAL   Ophthalmology 102 (2), 246-255 (1995)
   PUBMED   7862413
REFERENCE   7  (bases 1 to 1559)
  AUTHORS   Nakazawa,M., Kikawa,E., Kamio,K., Chida,Y., Shiono,T. and Tamai,M.
  TITLE     Ocular findings in patients with autosomal dominant retinitis
            pigmentosa and transversion mutation in codon 244 (Asn244Lys) of
            the peripherin/RDS gene
  JOURNAL   Arch Ophthalmol 112 (12), 1567-1573 (1994)
   PUBMED   7993211
REFERENCE   8  (bases 1 to 1559)
  AUTHORS   Kajiwara,K., Hahn,L.B., Mukai,S., Travis,G.H., Berson,E.L. and
            Dryja,T.P.
  TITLE     Mutations in the human retinal degeneration slow gene in autosomal
            dominant retinitis pigmentosa
  JOURNAL   Nature 354 (6353), 480-483 (1991)
   PUBMED   1684223
REFERENCE   9  (bases 1 to 1559)
  AUTHORS   Begy,C. and Bridges,C.D.
  TITLE     Nucleotide and predicted protein sequence of rat retinal
            degeneration slow (rds)
  JOURNAL   Nucleic Acids Res 18 (10), 3058 (1990)
   PUBMED   2349107
REFERENCE   10 (bases 1 to 1559)
  AUTHORS   Travis,G.H., Brennan,M.B., Danielson,P.E., Kozak,C.A. and
            Sutcliffe,J.G.
  TITLE     Identification of a photoreceptor-specific mRNA encoded by the gene
            responsible for retinal degeneration slow (rds)
  JOURNAL   Nature 338 (6210), 70-73 (1989)
   PUBMED   2918924
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013021.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN09345330, SAMN12840119
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-702               JAXUCZ010000009.1  21578373-21579074   c
            703-949             JAXUCZ010000009.1  21567375-21567621   c
            950-1559            JAXUCZ010000009.1  21563770-21564379   c
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..1559
                     /gene="Prph2"
                     /gene_synonym="Rds; RSRDS"
                     /note="peripherin 2"
                     /db_xref="GeneID:25534"
                     /db_xref="RGD:3549"
     exon            1..702
                     /gene="Prph2"
                     /gene_synonym="Rds; RSRDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1162
                     /gene="Prph2"
                     /gene_synonym="Rds; RSRDS"
                     /note="retinal degeneration slow protein; retinal
                     degeneration, slow"
                     /codon_start=1
                     /product="peripherin-2"
                     /protein_id="NP_037153.1"
                     /db_xref="GeneID:25534"
                     /db_xref="RGD:3549"
                     /translation="MALLKVKFDQKKRVKLAQGLWLMNWLSVLAGIVLFSLGLFLKIE
                     LRKRSDVMDNSESHFVPNSLIGVGVLSCVFNSLAGKICYDALDPAKYAKWKPWLKLYL
                     AVCVFFNVILFLVALCCFLLRGSLESTLAYGLKNGMKYYRDTDTPGRCFMKKTIDMLQ
                     IEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSCCNPSS
                     PRPCIQYQLTNNSAHYSYDHQTEELNLWLRGCRAALLNYYSSLMNSMGVVTLLIWLFE
                     VSITAGLRFLHTALESVSNPEDPECESEGWLLENSVSETWKAFLESFKKLGKSNQVEA
                     EAADAGQAPEAG"
     exon            703..949
                     /gene="Prph2"
                     /gene_synonym="Rds; RSRDS"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1559
                     /gene="Prph2"
                     /gene_synonym="Rds; RSRDS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccctgca gcttgggccc atggtgctct tcccaagacc ctgagtggtc cagcccctaa
       61 gctcattcgg gcttggagtg gaagctgaac taggggaggc tgctgaaccc cctcggtaag
      121 catggcgctg ctcaaagtca agtttgacca gaagaagcgg gtcaagttgg cccaggggct
      181 atggcttatg aactggctat ccgtgttggc cggcatcgtc ctcttcagcc tggggctgtt
      241 cctgaagatt gaactccgca agaggagtga cgtgatggat aactccgaga gccactttgt
      301 gcccaactcc ctgattgggg tgggggtcct gtcctgtgtc ttcaactctc tggctgggaa
      361 gatctgctat gacgccctgg accctgccaa gtacgccaag tggaagccct ggctgaagct
      421 gtacctggcc gtctgcgtct tctttaacgt catcctcttc ctggtggcgc tctgctgctt
      481 tctgctgcga ggctccctgg agagcaccct ggcgtacggg ctcaagaacg ggatgaagta
      541 ctatcgggac acggacacgc caggccggtg cttcatgaaa aagaccatcg acatgctcca
      601 gatcgagttc aagtgctgtg ggaacaacgg cttccgggac tggttcgaga ttcagtggat
      661 cagcaatcgc tatctggact tttcctccaa ggaggtcaaa gaccgcatca agagtaatgt
      721 ggatgggagg tacctggtgg acggcgtccc cttcagctgc tgcaacccca gctccccgcg
      781 gccctgtatt cagtaccagc tcaccaacaa ctctgcgcac tacagctatg accaccagac
      841 cgaggagctc aacctctggc tgcggggttg cagggctgcc ctgctgaatt actacagcag
      901 cctcatgaac tccatgggcg ttgtcacgct tctcatctgg ctctttgagg tgagcatcac
      961 tgccggactc cgcttcctcc acacagcgct ggagagcgtg tccaacccgg aggaccctga
     1021 gtgtgagagc gagggctggt tgctggagaa tagcgtgtcc gagacctgga aggcctttct
     1081 ggagagcttt aaaaaactgg gcaagagcaa tcaggtggag gctgaagctg cagacgcagg
     1141 ccaggcccca gaggctggct gacggcctgg ggcgtctccc ttcctcacca cttagtggac
     1201 tccagggaat gtggataccc cttgtccagc tgaaggtcca aatttcccaa gaaagctggt
     1261 cacctactga ctctccttga cgtgggcctt gaagttcaga gtccttaggg cacactatgc
     1321 tacaaacatc ggtgaaatgg ctgcctgcaa atgtgagtga ctgaacacac tcccagtgga
     1381 tgcctgtctc acaggactgg ctagtccagg gctctgacca agtgtgagcc cagttctccc
     1441 ataggtgact ggccacacca agggcctccc cctccttagt agttagtgtc tgcctctttt
     1501 aagctctaag tttctgcatc ccaaccatta tttgacacat aaaatcaagg tgaaaaaac
//
