LOCUS       NM_012633               1754 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus peripherin (Prph), mRNA.
ACCESSION   NM_012633 XM_006257322
VERSION     NM_012633.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Gentil,B.J., McLean,J.R., Xiao,S., Zhao,B., Durham,H.D. and
            Robertson,J.
  TITLE     A two-hybrid screen identifies an unconventional role for the
            intermediate filament peripherin in regulating the subcellular
            distribution of the SNAP25-interacting protein, SIP30
  JOURNAL   J Neurochem 131 (5), 588-601 (2014)
   PUBMED   25113441
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Murthy,M., Bocking,S., Verginelli,F. and Stifani,S.
  TITLE     Transcription factor Runx1 inhibits proliferation and promotes
            developmental maturation in a selected population of inner
            olfactory nerve layer olfactory ensheathing cells
  JOURNAL   Gene 540 (2), 191-200 (2014)
   PUBMED   24582971
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Hagstrom,S.A., Watson,R.F., Pauer,G.J. and Grossman,G.H.
  TITLE     Tulp1 is involved in specific photoreceptor protein transport
            pathways
  JOURNAL   Adv Exp Med Biol 723, 783-789 (2012)
   PUBMED   22183407
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Reid,A.J., Welin,D., Wiberg,M., Terenghi,G. and Novikov,L.N.
  TITLE     Peripherin and ATF3 genes are differentially regulated in
            regenerating and non-regenerating primary sensory neurons
  JOURNAL   Brain Res 1310, 1-7 (2010)
   PUBMED   19913522
  REMARK    GeneRIF: This study demonistrated that differential expression of
            peripherin and NF-H after injury occurs in both cutaneous and
            muscular afferent neurons after injury.
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   Ho,C.L., Chin,S.S., Carnevale,K. and Liem,R.K.
  TITLE     Translation initiation and assembly of peripherin in cultured cells
  JOURNAL   Eur J Cell Biol 68 (2), 103-112 (1995)
   PUBMED   8575457
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Thompson,M.A. and Ziff,E.B.
  TITLE     Structure of the gene encoding peripherin, an NGF-regulated
            neuronal-specific type III intermediate filament protein
  JOURNAL   Neuron 2 (1), 1043-1053 (1989)
   PUBMED   2624740
REFERENCE   8  (bases 1 to 1754)
  AUTHORS   Aletta,J.M., Angeletti,R., Liem,R.K., Purcell,C., Shelanski,M.L.
            and Greene,L.A.
  TITLE     Relationship between the nerve growth factor-regulated clone 73
            gene product and the 58-kilodalton neuronal intermediate filament
            protein (peripherin)
  JOURNAL   J Neurochem 51 (4), 1317-1320 (1988)
   PUBMED   3418352
REFERENCE   9  (bases 1 to 1754)
  AUTHORS   Parysek,L.M., Chisholm,R.L., Ley,C.A. and Goldman,R.D.
  TITLE     A type III intermediate filament gene is expressed in mature
            neurons
  JOURNAL   Neuron 1 (5), 395-401 (1988)
   PUBMED   3272173
REFERENCE   10 (bases 1 to 1754)
  AUTHORS   Leonard,D.G., Gorham,J.D., Cole,P., Greene,L.A. and Ziff,E.B.
  TITLE     A nerve growth factor-regulated messenger RNA encodes a new
            intermediate filament protein
  JOURNAL   J Cell Biol 106 (1), 181-193 (1988)
   PUBMED   3339087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Jan 4, 2022 this sequence version replaced
            XM_006257322.4, NM_012633.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031878.1, SRR26643429.28748.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               JAXUCZ010000007.1  132097289-132097871
            584-644             JAXUCZ010000007.1  132098217-132098277
            645-740             JAXUCZ010000007.1  132098460-132098555
            741-908             JAXUCZ010000007.1  132098852-132099019
            909-1034            JAXUCZ010000007.1  132099116-132099241
            1035-1255           JAXUCZ010000007.1  132099325-132099545
            1256-1305           JAXUCZ010000007.1  132099634-132099683
            1306-1385           JAXUCZ010000007.1  132099862-132099941
            1386-1754           JAXUCZ010000007.1  132100698-132101066
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1754
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /note="peripherin"
                     /db_xref="GeneID:24688"
                     /db_xref="RGD:3414"
     exon            1..583
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1454
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /note="peripherin 1"
                     /codon_start=1
                     /product="peripherin"
                     /protein_id="NP_036765.3"
                     /db_xref="GeneID:24688"
                     /db_xref="RGD:3414"
                     /translation="MPSSASMSHHSSGLRSSISSTSYRRTFGPPPSLSPGAFSYSSSS
                     RFSSSRLLGSGSPSSSARLGSFRAPRAGALRLPSERLDFSMAEALNQEFLATRSNEKQ
                     ELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELEL
                     LGRERDRVQVERDGLAEDLGALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELE
                     RKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYE
                     NIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRG
                     TNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMAL
                     DIEIATYRKLLEGEESRISVPVHSFASLSLKTTVPEVEPPQDSHSRKMVLIRTIETRD
                     GEKVVTESQKEQHSELDKSSIHSY"
     exon            584..644
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..740
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..908
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1034
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1255
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1305
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1385
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1754
                     /gene="Prph"
                     /gene_synonym="Perf; Prph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcccggcc tagttctgcc aagcgctgaa tgccatcttc cgccagcatg agccatcact
       61 cgtcgggcct ccggtccagc atcagctcca cctcataccg ccggaccttc gggccaccgc
      121 cctcactgtc ccccggggct ttctcctact catccagctc tcgcttctcc agcagccgcc
      181 tgctgggctc ggggtccccg agctcctcgg cgcggctggg cagcttccgt gcccctcgag
      241 cgggggccct gcgcttgccc tcggagcgcc tcgacttctc catggccgag gccctcaacc
      301 aggagttcct ggccactcgg agcaacgaga agcaagagct acaggagctc aacgaccgct
      361 tcgccaactt catcgagaag gtgcgcttcc tggagcagca gaacgcagcc ctgcgcgggg
      421 agctgagcca ggcgcggggc caggagccgg cgcgcgccga ccagctgtgc cagcaggagc
      481 tgcgcgagct gcggcgcgaa ctggagctgc tgggccggga gcgcgaccgg gtgcaggtgg
      541 agcgcgacgg gctggcggag gacctggggg cgctcaagca gaggttagaa gaagaaactc
      601 gcaagcggga ggatgcggag cacaacctgg tgctcttccg taaggacgtg gacgacgcca
      661 cgctgtcccg cctagaacta gagcgcaaga tcgaatctct gatggacgaa attgagttcc
      721 tcaagaagct acacgaagag gagcttcgag acctgcaggt gagcgtggag agccagcagg
      781 tgcagcaggt ggaggtagag gcaacagtga agccagagct gaccgcggcg ctgagggaca
      841 tccgtgcaca gtatgagaac atcgcggcga agaatctgca ggaggcagag gagtggtata
      901 agtcaaaata cgctgacctg tccgatgctg ccaaccgcaa ccatgaggcc ctacgtcagg
      961 ccaagcagga gatgaacgag tcccgacgtc agatccagag tctgacgtgc gaagtggacg
     1021 ggcttcgtgg cacgaacgag gcactgctca gacagttgcg ggagctggag gagcagttcg
     1081 ccctggaggc tggagggtac caagcaggcg cagcacggct ggaggaagag cttcgacagc
     1141 tgaaggaaga gatggcgagg cacctgcgag agtaccagga gctcctcaac gtcaagatgg
     1201 ccctggacat cgagatagcc acctacagga agctactgga aggggaagag agccggatct
     1261 cagtgcccgt tcattccttt gcttccctaa gtttaaagac gactgtgcct gaggtggagc
     1321 ctccccagga cagccacagc cggaagatgg ttctgatcag gactatcgag actcgggatg
     1381 gggagaaggt ggtgacagag tctcagaagg agcagcacag tgaactggac aagtcttcta
     1441 ttcacagcta ctgaggcctc agctggatct ctgaggctga ctgaagcccg ttcctaagct
     1501 cgaaccctcc cttgcaccag tctgcaacca gtcctgctca gcatgtggca ccctcctagc
     1561 cgagctccag cccgatcctg aggctggacc tctccctgat gcattgatgt gacccatagc
     1621 tttcctgtcc ttggaagagg cgatgaagaa acccaggaca gcagatctgc tcaagaatga
     1681 ccccatggac tgtggggtgg gccagagtgt gagattcact ctgagtcaaa taaaatcgct
     1741 accgagagaa actc
//
