LOCUS       NM_001079766            3062 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus pre-mRNA processing factor 6 (Prpf6), mRNA.
ACCESSION   NM_001079766 XM_001055907 XM_345486
VERSION     NM_001079766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3062)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 3062)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 3062)
  AUTHORS   Tanackovic,G., Ransijn,A., Ayuso,C., Harper,S., Berson,E.L. and
            Rivolta,C.
  TITLE     A missense mutation in PRPF6 causes impairment of pre-mRNA splicing
            and autosomal-dominant retinitis pigmentosa
  JOURNAL   Am J Hum Genet 88 (5), 643-649 (2011)
   PUBMED   21549338
REFERENCE   4  (bases 1 to 3062)
  AUTHORS   Tripathi,V., Ellis,J.D., Shen,Z., Song,D.Y., Pan,Q., Watt,A.T.,
            Freier,S.M., Bennett,C.F., Sharma,A., Bubulya,P.A., Blencowe,B.J.,
            Prasanth,S.G. and Prasanth,K.V.
  TITLE     The nuclear-retained noncoding RNA MALAT1 regulates alternative
            splicing by modulating SR splicing factor phosphorylation
  JOURNAL   Mol Cell 39 (6), 925-938 (2010)
   PUBMED   20797886
REFERENCE   5  (bases 1 to 3062)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3062)
  AUTHORS   Wahl,M.C., Will,C.L. and Luhrmann,R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   7  (bases 1 to 3062)
  AUTHORS   Fan,S., Goto,K., Chen,G., Morinaga,H., Nomura,M., Okabe,T.,
            Nawata,H. and Yanase,T.
  TITLE     Identification of the functional domains of ANT-1, a novel
            coactivator of the androgen receptor
  JOURNAL   Biochem Biophys Res Commun 341 (1), 192-201 (2006)
   PUBMED   16414017
REFERENCE   8  (bases 1 to 3062)
  AUTHORS   Schaffert,N., Hossbach,M., Heintzmann,R., Achsel,T. and Luhrmann,R.
  TITLE     RNAi knockdown of hPrp31 leads to an accumulation of U4/U6
            di-snRNPs in Cajal bodies
  JOURNAL   EMBO J 23 (15), 3000-3009 (2004)
   PUBMED   15257298
REFERENCE   9  (bases 1 to 3062)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 3062)
  AUTHORS   Makarov,E.M., Makarova,O.V., Achsel,T. and Luhrmann,R.
  TITLE     The human homologue of the yeast splicing factor prp6p contains
            multiple TPR elements and is stably associated with the U5 snRNP
            via protein-protein interactions
  JOURNAL   J Mol Biol 298 (4), 567-575 (2000)
   PUBMED   10788320
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128779.1.
            
            On or before Dec 12, 2006 this sequence version replaced
            XM_345486.3, XM_001055907.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128779.1, FQ221925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..3062
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /note="pre-mRNA processing factor 6"
                     /db_xref="GeneID:366276"
                     /db_xref="RGD:1307103"
     exon            1..182
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2937
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /note="PRP6 pre-mRNA splicing factor 6 homolog; U5
                     snRNP-associated 102 kDa protein; PRP6 homolog; U5-102 kDa
                     protein; PRP6 pre-mRNA processing factor 6 homolog"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 6"
                     /protein_id="NP_001073234.1"
                     /db_xref="GeneID:366276"
                     /db_xref="RGD:1307103"
                     /translation="MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPV
                     DDRHAPPGKRTVGDQMKKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEAD
                     AIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSI
                     PEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGL
                     NTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTD
                     LNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMK
                     GTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRV
                     LRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENAR
                     KVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQ
                     DAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYA
                     LQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDV
                     PAARSILALAFQANPNSEEIWLAAVKLESENNEYERARRLLAKARSSAPTARVFMKSV
                     KLEWVLGNITAAQELCEEALRHYEDFPKLWMMKGQIEEQGELMERAREAYNQGLKKCP
                     HSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANT
                     LMAKALQECPNSGILWSEAVFLEARPQRKTKSVDALKKCEHDPHVLLAVAKLFWSERK
                     ITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCENAEPRHGELWCA
                     VSKDITNWQRKIGEILVLVAARIKNTF"
     exon            183..351
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            352..470
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            471..549
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            550..726
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            727..882
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            883..977
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1134
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1297
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1416
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1635
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1758
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1880
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2019
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2139
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2316
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2450
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2542
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2657
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2784
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..3036
                     /gene="Prpf6"
                     /gene_synonym="RGD1307103"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgtactga ctgcatctct tccagctgcg acactgggaa gactttgagc tttctgccgc
       61 gtacttgctc ccctgctttt ctttttctct gtttcggcca acagcaccgc catgaacaag
      121 aagaagaagc cgttcctggg catgcccgcg ccgctgggct acgtaccggg gctgggccgg
      181 ggtgccacag gcttcaccac ccgatcagac attgggcctg ctcgggatgc aaacgaccct
      241 gtggacgacc gccatgcccc accagggaag agaactgtgg gggaccagat gaagaaaaac
      301 caggctgctg atgacgatga tgaggatctg aacgatacca actacgatga gtttaatggc
      361 tatgctggaa gcctcttctc aagtgggccc tatgaaaaag atgatgagga agcagatgct
      421 atttacgcag ctctggataa gaggatggat gagagaagaa aagagagaag agagcaaagg
      481 gaaaaagaag agattgagaa ataccgaatg gaacgtccca aaatccagca gcagttttca
      541 gaccttaaga ggaagttggc agaggtcaca gaagaagaat ggcttagcat cccagaagtt
      601 ggcgatgcca gaaacaaacg tcaacggaac ccacgttatg agaagctgac ccctgttcct
      661 gatagtttct ttgccaaaca tttacagact ggagagaacc atacttccgt ggatccccga
      721 caaactcaat ttggaggtct gaatactccc tacccaggag gcctgaacac tccataccca
      781 ggtggaatga caccaggatt gatgacacct ggaacagggg agctggacat gaggaagatt
      841 ggccaggcca ggaataccct gatggacatg aggcttagcc aggtatctga ctcagtgagt
      901 gggcagactg ttgtggaccc caaaggctat ctgacggacc taaactctat gatcccaacc
      961 catggtggcg atataaatga catcaagaaa gcacgactac ttcttaaatc tgttcgagaa
     1021 acaaaccctc atcatccacc agcctggatt gcgtcagctc gcctggaaga agtcactgga
     1081 aagttacaag tggctcgaaa ccttattatg aaagggacag agatgtgccc caagagtgaa
     1141 gatgtctggc tagaagcagc taggttacag cctggggaca cagccaaggc tgtggtggca
     1201 caagctgtcc gtcatctccc acagtctgtt aggatttaca ttagagcagc agaactagaa
     1261 acagacattc gagcaaagaa gcgtgttctt cggaaagccc ttgagcatgt tccaaactcc
     1321 gttcgattgt ggaaagcagc tgttgagctt gaagagcctg aagatgctag aatcatgctg
     1381 agccgagcag tagagtgctg tcccaccagt gtagagctct ggcttgcttt ggcaaggctg
     1441 gaaacttatg aaaatgctcg aaaggtctta aataaagcac gtgagaacat tcctacagat
     1501 cggcacatct ggatcaccgc tgccaagctt gaggaggcca atgggaacac tcagatggtg
     1561 gagaagatca ttgaccgagc catcacgtct cttcgggcca atggtgtaga gattaatcgc
     1621 gaacagtgga tccaggatgc tgaggagtgt gacagggcag ggagtgtggc cacgtgccag
     1681 gccgtcatgc gtgctgtgat cggtatcggg atagaggagg aagatcgcaa acacacctgg
     1741 atggaagacg ctgacagttg tgtggcccac aatgccctgg agtgtgcacg agccatatat
     1801 gcctatgccc tacaagtctt ccccagcaag aaaagtgtgt ggttacgagc tgcatacttt
     1861 gagaagaacc atggtaccag ggagtctttg gaagcgctct tgcagagggc tgtggcccac
     1921 tgccccaagg cagaggtgct gtggctcatg ggtgccaagt cgaagtggct ggcaggggat
     1981 gtccctgcag caagaagcat cctggccctg gcctttcagg ccaaccccaa cagcgaagag
     2041 atctggctgg cggctgtgaa gctggagtca gagaacaatg agtacgagcg agcccggagg
     2101 ctgctggcca aggcccggag cagcgcaccc accgcccgtg tgttcatgaa gtctgtgaag
     2161 ctggagtggg tgctggggaa catcactgcc gcacaggagc tgtgcgagga ggctctgagg
     2221 cactatgaag atttccccaa gctgtggatg atgaaggggc agattgagga gcaaggagag
     2281 ctgatggaga gggcccggga ggcctacaac caggggttga agaaatgtcc tcactccacg
     2341 ccactgtggc tcttgctttc ccggctagag gaaaagattg ggcagctgac tcgtgctcgg
     2401 gccattttag agaaatctcg tctgaaaaac ccaaagaacc ctgggctgtg gttggagtca
     2461 gtgcggctgg agtaccgggc agggctgaag aatattgcca ataccctcat ggccaaggcg
     2521 ctgcaggagt gccctaactc tggtatcctg tggtctgaag ctgtcttcct tgaggcaagg
     2581 ccccagagaa agaccaagag tgtggatgcc ctgaagaagt gtgaacatga cccccatgtg
     2641 cttttagctg tggctaagct gttctggagt gaaagaaaga tcaccaaggc tcgggagtgg
     2701 ttccatcgca ccgtgaagat tgattcagat ctgggggatg cctgggcctt cttctacaaa
     2761 tttgaactac agcatggcac tgaggagcaa caggaagagg tgaggaaacg ctgtgagaat
     2821 gcagagcccc gacatggaga gctgtggtgt gctgtgtcca aggatatcac caactggcag
     2881 agaaagattg gggaaatcct agtgctggtg gccgcccgta tcaaaaacac cttctgatag
     2941 caggggcgga ggacaaggca ctttggggca gcacatggac aatgagcaca aaacctacac
     3001 tgtatctttt attcattaaa gatttttata gagttgaaaa aaaaaaaaaa aaaaaaaaaa
     3061 aa
//
